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Human BAMBI/NMA Antibody

Catalog #: AF921
4 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
AF921
AF921-SP
BAMBI/NMA in Human Kidney.
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Citations (4)
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Summary Data Examples Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human BAMBI/NMA Antibody Summary

Species Reactivity
Human
Specificity
Detects human BAMBI/NMA in direct ELISAs and Western blots.
Source
Polyclonal Goat IgG
Purification
Antigen Affinity-purified
Immunogen
Mouse myeloma cell line NS0-derived recombinant human BAMBI/NMA
Glu27-Ala152
Accession # Q13145
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Western Blot
0.1 µg/mL
Recombinant Human BAMBI/NMA
Immunohistochemistry
5-15 µg/mL
See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Immunohistochemistry BAMBI/NMA antibody in Human Kidney by Immunohistochemistry (IHC-P). View Larger

BAMBI/NMA in Human Kidney. BAMBI/NMA was detected in immersion fixed paraffin-embedded sections of human kidney using Goat Anti-Human BAMBI/NMA Antigen Affinity-purified Polyclonal Antibody (Catalog # AF921) at 3 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS008) and counterstained with hematoxylin (blue). Specific staining was localized to cytoplasm in tubular epithelial cells. View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Reconstitute at 0.2 mg/mL in sterile PBS.
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Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: BAMBI/NMA

BAMBI/NMA is a type I transmembrane protein that shares sequence homology with the TGF-beta type I receptor family protein but has a short cytoplasmic region that lacks the kinase domain. It functions as a membrane-bound decoy receptor by competing with type I receptors to form a heterodimer with type II receptors. Mouse BAMBI/NMA share approximately 93% amino acid sequence homology with human BAMBI/NMA.

Long Name
BMP and Activin Membrane-bound Inhibitor
Entrez Gene IDs
25805 (Human); 68010 (Mouse)
Alternate Names
BAMBI; BMP and activin membrane-bound inhibitor homolog (Xenopus laevis); BMP and activin membrane-bound inhibitor homolog; NMA; NMANon-metastatic gene A protein; Putative transmembrane protein NMA

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Citations for Human BAMBI/NMA Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

4 Citations: Showing 1 - 4
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  1. BAMBI regulates macrophages inducing the differentiation of Treg through the TGF-? pathway in chronic obstructive pulmonary disease
    Authors: SW Sun, L Chen, M Zhou, JH Wu, ZJ Meng, HL Han, SY Miao, CC Zhu, XZ Xiong
    Respir. Res., 2019-02-06;20(1):26.
    Species: Human
    Sample Types: Tissue Homogenates
    Applications: Western Blot
  2. C-terminal-truncated HBV X promotes hepato-oncogenesis through inhibition of tumor-suppressive ?-catenin/BAMBI signaling
    Authors: Seok Lee
    Exp. Mol. Med, 2016-12-02;48(12):e275.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  3. TGF-?/BAMBI pathway dysfunction contributes to peripheral Th17/Treg imbalance in chronic obstructive pulmonary disease
    Sci Rep, 2016-08-23;6(0):31911.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  4. Identification of BMP and activin membrane-bound inhibitor (BAMBI) as a potent negative regulator of adipogenesis and modulator of autocrine/paracrine adipogenic factors.
    Authors: Luo X, Hutley LJ, Webster JA, Kim YH, Liu DF, Newell FS, Widberg CH, Bachmann A, Turner N, Schmitz-Peiffer C, Prins JB, Yang GS, Whitehead JP
    Diabetes, 2012-01-01;61(1):124-36.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot

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