Researchers at the University of Colorado Cancer Center have found the upregulation of CDK1 and its direct interaction with Sox2 play a crucial role in the development...
September 2018 Go Everywhere with Bio-Techne Travel Grant Awarded to a Research Associate from Wayne State University!
Bio-Techne's Go Everywhere Travel Grant Program awards $1000 USD (or equivalent) to one researcher each month to attend the meeting of their choice. This grant program allows the researcher to attend more targeted meetings in their field and provides funding to support both small and large scientific associations that promote discovery and collaboration.
The recipient of the September 2018 grant is Dr. Samaresh Sau, a Research Associate in the Pharmaceutical Science department at Wayne State University in Detroit, Michigan (USA).
This technical video provides an overview of the methodologies, tools, and reagents used to generate multicellular tumor spheroids. Specifically, this video discusses the benefits of Cultrex® extracellular matrices for spheroid formation and analysis. Technical tips are provided for using colorimetric and fluorometric assays to evaluate cell proliferation and invasion of spheroids.
This protocol video was originally recorded by Dr. Gabriel Benton at Trevigen, Inc. The Trevigen portfolio, including tools for creating 3-D and spheroid cultures, are now a part of R&D Systems, a Bio-Techne brand.
In this technical video you will learn:
Evolution of extracellular matrices used for 3-D cell culture
We are excited to launch new changes to the R&D Systems site! The site has new functionality and design to enhance the overall customer experience. Some changes that you will see on the site:
Responsive Layout: The website will size appropriately to the device that you are using, including desktop computers, mobile phones, and tablets.
Datasheets/Product Data Pages: A new layout for the entire page for all the tabs and sections. You can filter product reviews, find related products and scroll through images in the new lightbox.
Recombinant Human DLL3 Now Available
Delta-like protein 3 (DLL3) is a transmembrane protein that belongs to the Delta/Serrate/Lag-2 (DSL) family of Notch ligands. It has received much recent attention due to its potential as a target for small cell lung cancer.
Watch this short video highlighting our CellXVivo™ kits developed for the consistent differentiation and expansion of T cells subtypes, dendritic cells, B cells, cytotoxic cells, and more. Kits include buffers, cytokines and optimized protocols for easy and reproducible cell culture.
Bio-Techne’s Go Everywhere Travel Grant Program awards $1000 USD (or equivalent) to one researcher each month to attend the meeting of their choice. This grant program allows the researcher to attend more targeted meetings in their field and provides funding to support both small and large scientific associations that promote discovery and collaboration.
The recipient of the June 2018 grant is Lucy McDermott, a PhD Student in the Nuffield Department of Clinical Neurosciences at the University of Oxford in Oxford, England.
Myeloid-derived suppressor cells (MDSCs) are a diverse population of immature myeloid cells with immunosuppressive properties that accumulate under pathological conditions including specific types of cancer and infections. Two primary subsets of human and mouse MDSCs known as granulocytic and monocytic MDSCs have been identified. These cells are of great interest as high levels of circulating MDSCs in cancer patients have been shown to correlate with clinical stage, metastatic burden, and resistance to both chemotherapy and immunotherapy. As a result, MDSCs are now recognized as a major obstacle in the treatment of cancer. Multiple strategies targeting these cells are being investigated to determine if the...
Antibodies are critical tools in the majority of research and clinical studies. However, unreliable antibodies with poor specificity or reproducibility remain a significant drain on resources across biomedical research and industry. Widespread acceptance of the need for end-user antibody validation has led to high profile initiatives and guidance (e.g. Uhlen et al, Nat. Methods 2016). Aligning to these principles, the AstraZeneca Affinity Reagent Group provides company-wide advice and scientific support in the validation of both commercial and our bespoke antibodies generated in-house. Our work feeds into activities across the drug discovery pipeline, including target identification / validation, hit-...
Another exciting International Society for Stem Cell Research (ISSCR) Annual Meeting has concluded. This year’s meeting, held in Melbourne, Australia (June 19-22nd, 2018), enabled the local stem cell research community to shine with many plenary talks, scientific presentations, and posters provided by researchers from Melbourne Universities and Hospitals. It was impressive! Many stem cell scientists were unable to attend the meeting due to the exotic and remote location. This summary will provide a snapshot of scientific themes and interesting science featured at the meeting.
Stem Cell Therapy
ISSCR 2018 was bookended by two invigorating symposia highlighting...
Chemokine receptors and other multipass proteins require special consideration when staining live cells for flow cytometry analysis. These receptors have seven transmembrane domains, all of which are fluid and moving around in the cell membrane. As a result, the three extracellular loops, to which antibodies must bind, are also moving and this motion can change the orientation of antibody binding sites. While this domain flexibility is necessary for ligand binding to the receptor, it can create problems for flow cytometry staining of live cells. In addition to movement within the lipid membrane, chemokine receptors can undergo internalization and endocytic recycling,...
May 2018 Go Everywhere with Bio-Techne Travel Grant Awarded to PhD Student from the University of Padova!
Bio-Techne’s Go Everywhere Travel Grant Program awards $1000 USD (or equivalent) to one researcher each month to attend the meeting of their choice. This grant program allows the researcher to attend more targeted meetings in their field and provides funding to support both small and large scientific associations that promote discovery and collaboration.
The recipient of the May 2018 grant is Diana Piol, a PhD Student in the Biomedical Sciences department at the University of Padova in Padova, Italy!
Researchers have long been attempting to identify and validate specific biomarkers for Alzheimer’s disease (AD). AD is a neurodegenerative disorder that is characterized by brain atrophy resulting from neuronal loss. It is typically diagnosed following a series of clinical assessments that include neurological and mental examinations and brain imaging. However, since many other disorders also display AD-like symptoms, the only way to definitively diagnosis AD is by tying clinical assessment of the disease to the postmortem identification of its pathological hallmarks (i.e. senile plaques...
Bio-Techne was pleased to be a sponsor of the 4th Annual University of Minnesota Neuro-Oncology Symposium. The preclinical Provider/Researcher program included 4 sessions: Physics and Modeling, Blood Brain Barrier, Genetics, and Immunotherapy/Emerging Therapies. The clinical Patient/Caregiver program included 2 sessions: Treatment & Therapies and Living with a Brain Tumor.
New Recombinant Antibodies Added Every Week: Over 700 Antibodies and Growing
Biology introduces more than enough variability for researchers to worry about without adding inconsistent reagents to the equation. Start minimizing one major source of experimental variability in your research by using recombinant antibodies. We...
Bio-Techne’s Go Everywhere Travel Grant Program awards $1000 USD (or equivalent) to one researcher each month to attend the meeting of their choice. This grant program allows the researcher to attend more targeted meetings in their field and provides funding to support both small and large scientific associations that promote discovery and collaboration.
The recipient of the April 2018 grant is Linda Ban, a PhD Candidate in the Endocrinology department at the University of Sydney!
Bio-Techne and our family of brands provide a unique portfolio of products and services that support basic research, and we are positioning ourselves as a leader in the autophagy field through the support of several autophagy-focused conferences in 2018 and by sharing our autophagy research with the scientific community at these conferences.
Our commitment to high-quality reagents and services was recently honored by CiteAb, which identified our LC3B antibody (catalog #NB100-2220...
On January 2, 2018, Bio-Techne, the parent company of R&D Systems, proudly announced its acquisition of Atlanta Biologicals, Inc. As noted by Bio-Techne President and Chief Executive Officer, Charles R. Kummeth, "Atlanta Biologicals is a great fit with the Bio-Techne product portfolio as we continue to expand our cell culture and tissue regeneration capabilities. Many of our products are used in tissue culture applications and the Atlanta Biologicals fetal bovine serum (FBS) product line strengthens and complements our current tissue culture reagents offering and furthers our efforts to provide more complete solutions...
Shamain Dang, Bio-Techne Support Specialist - Cell Therapy and GMP Solutions chats with Yinfei Yin, Technical Director, Crown Bioscience. (from left to right)
Scientists from Crown Bioscience presented some of their latest data at the 2018 American Association of Cancer Research (AACR) in Chicago this month. The authors used Cultrex® Basement Membrane Extract in the development of a novel 3-D tumor...