Apoptosis Inducer Compounds: Products

Apoptosis inducers produce pro-apoptotic effects via different mechanisms. These include DNA cross-linking, inhibition of antiapoptotic proteins, and activation of caspases.

"Apoptosis Inducer Compounds" has 32 results in Products.
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Cisplatin 

Potent pro-apoptotic anticancer agent; activates caspase-3

Doxorubicin hydrochloride 

Antitumor antibiotic agent. Inhibits DNA topoisomerase II

Mitomycin C 

DNA cross-linking antitumor agent

Actinomycin D 

Inhibits RNA polymerase

Oxaliplatin 

DNA cross-linking antitumor agent

Temozolomide 

DNA-methylating antitumor agent

Cyclophosphamide 

Alkylating agent; chemotherapeutic

Carboplatin 

DNA cross-linking antitumor agent

Triptolide 

Inhibits RNAPII-mediated transcription; antitumor, anti-inflammatory and immunosuppressive

Fludarabine 

Purine analog; inhibits DNA synthesis

Streptozocin 

DNA alkylator; antitumor and induces diabetes

Betulinic acid 

Antitumor and anti-HIV agent; activates NF-κB. Also TGR5 agonist

iMDK 

Suppressor of MDK expression; inhibits PI 3-K signaling

Apoptosis Activator 2 

Promotes apoptosome formation and activates caspase-9/caspase-3 pathway. Selectively induces tumor cell apoptosis

AT 101 

Downregulates Bcl-2 and Mcl-1; pro-apoptotic

Kaempferol 

Proapoptotic; downregulates PLK1 expression and activates mitochondrial Ca2+ uniporter

SMBA 1 

High affinity and selective activator of Bax

ABT 737 

Bcl-2 family inhibitor; mimics BH3 and induces apoptosis in cancer cell lines

Evofosfamide 

Hypoxia-activated DNA alkylating agent prodrug
Func

2,3-DCPE hydrochloride 

Selectively induces cancer cell apoptosis

C 75 

Potent fatty acid synthase inhibitor; proapoptotic

Bendamustine hydrochloride 

Cytostatic agent; exhibits DNA alkylating and purine analog properties

Narciclasine 

Stimulates RhoA activation; antiproliferative agent that slows cell cycle progression

PCI 34051 

Potent and selective HDAC8 inhibitor

Cladribine 

Deoxyadenosine analog; pro-apoptotic

MRT 68921 dihydrochloride 

ULK inhibitor

5-Ethynyl-2'-deoxyuridine 

Thymidine analog for labeling DNA; can be linked to a fluorophore by click chemistry

Panobinostat 

Pan-histone deacetylase inhibitor

ABT 263 

High affinity Bcl-2 family inhibitor; proapoptotic, senolytic and antitumor

Trametinib 

Potent and selective MEK inhibitor; orally bioavailable

LYN 1604 dihydrochloride 

Potent UNC-51-like kinase 1 (ULK1) agonist

Belinostat 

Potent pan-HDAC inhibitor
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