PCI 34051
Chemical Name: N-Hydroxy-1-[(4-methoxyphenyl)methyl]-1H-indole-6-carboxamide
Purity: ≥98%
Biological Activity
PCI 34051 is a potent and selective histone deacetylase 8 (HDAC8) inhibitor (IC50 = 10 nM). Displays >200 fold selectivity over HDAC isoforms 1, 2, 3, 6 and 10. Induces apoptosis in cell lines derived from T cell lymphomas or leukemias.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Histone deacetylase inhibitor treatment dramatically reduces cholesterol accumulation in Niemann-Pick type C1 mutant human fibroblasts.
Pipalia et al.
Proc.Natl.Acad.Sci.U.S.A., 2011;108:5620 -
A novel histone deacetylase 8 (HDAC8)-specific inhibitor PCI-34051 induces apoptosis in T-cell lymphomas.
Balasubramanian et al.
Leukemia, 2008;22:1026
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Citation for PCI 34051
The citations listed below are publications that use Tocris products. Selected citations for PCI 34051 include:
1 Citation: Showing 1 - 1
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Suppression of TGFβ-mediated conversion of endothelial cells and fibroblasts into cancer associated (myo)fibroblasts via HDAC inhibition
Authors: Kim
Br J?Cancer 2018;118(10):1359
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