MRT 68921 dihydrochloride
Chemical Name: N-[3-[[5-Cyclopropyl-2-[(1,2,3,4-tetrahydro-2-methyl-6-isoquinolinyl)amino]-4-pyrimidinyl]amino]propyl]cyclobutanecarboxamide dihydrochloride
Purity: ≥98%
Biological Activity
MRT 68921 dihydrochloride is a potent ULK inhibitor (IC50 values are 1.1 and 2.9 nM for ULK2 and ULK1, respectively). Inhibits autophagy in mouse embryonic fibroblasts.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Pharmacological inhibition of ULK1 kinase blocks mammalian target of rapamycin (mTOR)-dependent autophagy.
Petherick et al.
J.Biol.Chem., 2015;290:11376
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Citations for MRT 68921 dihydrochloride
The citations listed below are publications that use Tocris products. Selected citations for MRT 68921 dihydrochloride include:
6 Citations: Showing 1 - 6
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Loss of function of FIP200 in human pluripotent stem cell-derived neurons leads to axonal pathology and hyperactivity.
Authors: Andreas Et al.
Transl Psychiatry 2023;13:143
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Targeting retinoic acid receptor alpha-corepressor interaction activates chaperone-mediated autophagy and protects against retinal degeneration.
Authors: Patricia Et al.
Nat Commun 2022;13:4220
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Authentic and Ectopically Expressed MRGPRX2 Elicit Similar Mechanisms to Stimulate Degranulation of Mast Cells.
Authors: Pia Et al.
Cells 2021;10
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Endoplasmic reticulum tubules limit the size of misfolded protein condensates.
Authors: Jesse C Et al.
Elife 2021;10
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The mito-QC Reporter for Quantitative Mitophagy Assessment in Primary Retinal Ganglion Cells and Experimental Glaucoma Models.
Authors: Elena Et al.
Int J Mol Sci 2020;21
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Podocytes maintain high basal levels of autophagy independent of mtor signaling.
Authors: Wei Et al.
Autophagy 2020;16:1932-1948
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