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Inhibits hepatitis C viral life cycle; also α-crystallin (cryAB) chaperone
Potent and selective VPAC2 agonist
Toll-like receptor 7 (TLR7) agonist
Selective PC-PLC inhibitor
Specific inhibitor of NF-κB activation
mSTING agonist; induces antitumor immunological responses
Viral RNA-dependent RNA polymerase (RdRP) inhibitor; broad spectrum antiviral nucleotide prodrug
α-glucosidase I and II inhibitor; also inhibits ceramide-specific glycosyltransferases and exhibits broad spectrum antiviral activity
Toll-like receptor 7 (TLR7) agonist
Selective CCR5 antagonist
Selective reverse transcriptase inhibitor; antiretroviral
Core binding factor inhibitor; attenuates hematopoiesis
DNA polymerase α, δ and ε inhibitor
HIV-1 and HIV-2 protease inhibitor
Potent and selective HIV-1 and HIV-2 protease inhibitor
Potent and selective HIV-1 and HIV-2 protease inhibitor
Influenza virus neuraminidase inhibitor; antiviral prodrug
Coronavirus PLpro inhibitor
Inosine monophosphatase dehydrogenase (IMPDH) inhibitor
Potent MEK1 inhibitor. Also inhibits IκBα phosphorylation
Selective inhibitor of Akt/PKB signaling. Antitumor and antiviral
BLT1/BLT2 receptor agonist and potent chemotactic factor
Chemokine receptor 5 (CCR5) antagonist
Inhibits viral DNA polymerase; antiherpetic agent
p53 activator. Also ROS scavenger
Proapoptotic; downregulates PLK1 expression and activates mitochondrial Ca2+ uniporter
Reverse transcriptase inhibitor
Potent HIV-1 protease inhibitor
Blocks eIF4E activity; antiviral guanosine analog
2,3-Oxidosqualene cyclase (OSC) inhibitor; blocks cholesterol synthesis
Potent and selective PI 4-kinase IIIβ inhibitor
Potent and selective CCR5 and CCR2 chemokine receptor antagonist
Potent and selective CCR5 and CCR2 chemokine receptor antagonist
Promotes Akt hyperphosphorylation; decreases phosphorylation of Akt substrates
Antiflaviviral; active against Zika, Dengue and Hepatitis C viruses
Potent and selective hepatitis B virus inhibitor
Potent and selective PI 4-kinase IIIβ inhibitor; broad spectrum enterovirus replication inhibitor
Oligosaccharyltransferase (OST) inhibitor; anti-flaviviral
Inhibitor of HCV RNA-dependent RNA polymerase (RdRP; NS5b); potent hepatitis C virus (HCV) replication inhibitor
STAT5-SUMO protein-protein interaction inhibitor
Highly potent and selective HIV-1 protease inhibitor
Potent influenza virus neuraminidase inhibitor
Potent and selective Src tyrosine kinase family inhibitor; anticancer; antiviral; orally bioavailable
SKP2 (S-phase kinase-associated protein 2) inhibitor; upregulates p27 and arrests cell cycle in G1 phase
Viral RNA polymerase inhibitor
Viral RNA-dependent RNA polymerase (RdRP) inhibitor; broad spectrum antiviral nucleotide
Viral RNA-dependent RNA polymerase (RdRP) inhibitor; broad spectrum antiviral