Indinavir sulfate

Biological Activity

Indinavir sulfate is a potent and selective HIV protease inhibitor (K_i values are 0.52 and 3.3 nM for HIV-1 and HIV-2, respectively). Indinavir stops the spread of the HIV-infected MT4 lymphoid cells at concentrations of 25-50 nM. Indinavir disrupts the ERK1/2 and p38 MAPK pathways and reduces both the level of functional eIF4F complex and rpS6 phosphorylation, which leads to a decrease in protein synthesis in mouse myocytes. In silico docking models predict potential as an inhibitor of SARS-CoV-2 3CL^pro.

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. Indinavir alters regulators of protein anabolism and catabolism in skeletal muscle.
   Hong-Brown LQ, Pruznak AM, Frost RA et al.
   Am J Physiol Endocrinol Metab
2. A search for medications to treat COVID-19 via in silico molecular docking models of the SARS-CoV-2 spike glycoprotein and 3CL protease.
   Hall and Hai-Feng et al.
   Travel Med.Infect.Dis., 2020;

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