MI 14
Chemical Name: N-[2-[[6-Chloro-3-[3-[(dimethylamino)sulfonyl]phenyl]-2-methylimidazo[1,2-b]pyridazin-8-yl]amino]ethyl]acetamide
Purity: ≥98%
Biological Activity
MI 14 is a potent and selective PI 4-K IIIβ inhibitor (IC50 = 54 nM). Exhibits >1,800-fold selectivity for PI 4-K IIIβ over PI 4-K IIIα and PI 4-K IIα, respectively. Exhibits antiviral activity against single-stranded positive sense RNA viruses in HeLa cell-based assays.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Highly selective phosphatidylinositol 4-kinase IIIβ inhibitors and structural insight into their mode of action.
Mejdrová et al.
J.Med.Chem., 2015;58:3767
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Citation for MI 14
The citations listed below are publications that use Tocris products. Selected citations for MI 14 include:
1 Citation: Showing 1 - 1
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Conformational specificity of opioid receptors is determined by subcellular location irrespective of agonist.
Authors: Wooree Et al.
Elife 2021;10
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