Human TMEM119 Alexa Fluor® 405-conjugated Antibody
Human TMEM119 Alexa Fluor® 405-conjugated Antibody Summary
Arg26-Met96
Accession # Q4V9L6.1
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
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Preparation and Storage
- 12 months from date of receipt, 2 to 8 °C as supplied.
Background: TMEM119
TMEM119 (Transmembrane Protein 119, also known as Osteoblast
Induction Factor or OBIF), is an approximately 38-kDa type 1 transmembrane
protein that is predominantly expressed in osteoblasts and is upregulated
during osteoblastic differentiation (1, 2). TMEM119 is also expressed in a cell
line of microglia, and TMEM119 immunoreactivity is observed in a specific
subset of microglia in brains of neurodegenerative diseases, such as Alzheimer's
disease (3). Mature human TMEM119 consists of a 71 amino acid (aa)
extracellular domain (ECD), a 21 aa transmembrane segment, and a 166 aa
cytoplasmic domain. Within the ECD, human TMEM119 shares 78% and 75% aa
sequence identity with mouse and rat TMEM119, respectively. TMEM-119 is
involved in the osteoblast differentiation and bone development by acting as a
ligand and has been reported to contribute to the proliferation, migration, and
invasion of osteosarcoma cells, as well as functioning as an oncogene in
osteosarcoma (3, 4).
- Jiang, Z,H. et al. (2017) Expt & Mol Med. 49:e329.
- Mizuhashi, K. et al. (2012) Dev. Growth Differ. 54:474.
- Satoh, J. et al. (2016) Neuropathol. 36:39.
- Kanamoto, T. et al. (2009) BMC Develop. Biol. 9:70.
Product Datasheets
Product Specific Notices
This product is provided under an agreement between Life Technologies Corporation and R&D Systems, Inc, and the manufacture, use, sale or import of this product is subject to one or more US patents and corresponding non-US equivalents, owned by Life Technologies Corporation and its affiliates. The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components (1) in manufacturing; (2) to provide a service, information, or data to an unaffiliated third party for payment; (3) for therapeutic, diagnostic or prophylactic purposes; (4) to resell, sell, or otherwise transfer this product or its components to any third party, or for any other commercial purpose. Life Technologies Corporation will not assert a claim against the buyer of the infringement of the above patents based on the manufacture, use or sale of a commercial product developed in research by the buyer in which this product or its components was employed, provided that neither this product nor any of its components was used in the manufacture of such product. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, Cell Analysis Business Unit, Business Development, 29851 Willow Creek Road, Eugene, OR 97402, Tel: (541) 465-8300. Fax: (541) 335-0354.
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