Human Pleiotrophin/PTN Biotinylated Antibody Summary
Gly33-Asp168
Accession # Q6ICQ5
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: Pleiotrophin/PTN
PTN was identified independently by several groups as a novel heparin-binding, developmentally regulated cytokine. Depending on the biological activities studied, this protein has variously been referred to as heparin-binding brain mitogen (HBBM), heparin-binding growth factor-8 (HBGF-8), heparin-binding neurite promoting factor, heparin-binding neurotrophic factor (HBNF), heparin-affinity regulatory peptide (HARP), heparin-binding growth-associated molecule (HB-GAM), osteoblast‑specific factor (OSF-1), and pleiotrophin. PTN is a highly conserved protein; the amino acid sequences of human, bovine, rat, and mouse PTN share > 98% homology.
PTN is a member of a family of heparin-binding proteins that share sequence, structural, and functional similarity. Other members of this family include midkine (MK), and chicken retinoic acid-induced heparin-binding protein (RI-HB), an avian homologue of MK. The expression of all these cytokines is restricted and highly regulated during development.
PTN can be used as an attachment substrate to stimulate neurite outgrowth in mixed cultures of embryonic rat, mouse or chicken brain cells. Although both natural and recombinant human PTN have been reported to be mitogenic for fibroblasts, endothelial, and epithelial cells, the data are still highly controversial. PTN has been shown to transform NIH-3T3 and SW-13 cells, as evidenced by anchorage-independent growth and tumor formation in the nude mouse. These results suggest that, in spite of the conflicting reports of PTN’s growth-promoting activity in vitro, PTN may have a role in abnormal cell growth in vivo.
Product Datasheets
Citations for Human Pleiotrophin/PTN Biotinylated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Discovery of PTN as a serum-based biomarker of pro-metastatic prostate cancer
Authors: S Liu, M Shen, EC Hsu, CA Zhang, F Garcia-Mar, R Nolley, K Koul, MA Rice, M Aslan, SJ Pitteri, C Massie, A George, JD Brooks, VJ Gnanapraga, T Stoyanova
British Journal of Cancer, 2020-12-08;0(0):.
Species: Human
Sample Types: Serum, Whole Tissue
Applications: ELISA Detection, IHC -
Pericyte loss leads to circulatory failure and pleiotrophin depletion causing neuron loss
Authors: AM Nikolakopo, A Montagne, K Kisler, Z Dai, Y Wang, MT Huuskonen, AP Sagare, D Lazic, MD Sweeney, P Kong, M Wang, NC Owens, EJ Lawson, X Xie, Z Zhao, BV Zlokovic
Nat. Neurosci., 2019-06-24;22(7):1089-1098.
Species: Transgenic Mouse
Sample Types: CSF
Applications: ELISA Detection -
Pleiotrophin gene therapy for peripheral ischemia: evaluation of full-length and truncated gene variants.
Authors: Fang Q, Mok P, Thomas A, Haddad D, Saini S, Clifford B, Kapasi N, Danforth O, Usui M, Ye W, Luu E, Sharma R, Bartel M, Pathmanabhan J, Ang A, Sievers R, Lee R, Springer M
PLoS ONE, 2013-04-22;8(4):e61413.
Species: Mouse
Sample Types: Cell Culture Supernates, Whole Cells
Applications: Bioassay, ELISA Development (Detection) -
Pleiotrophin is highly expressed by myeloma cells and promotes myeloma tumor growth.
Authors: Chen H, Gordon MS, Campbell RA, Li M, Wang CS, Lee HJ, Sanchez E, Manyak SJ, Gui D, Shalitin D, Said J, Chang Y, Deuel TF, Baritaki S, Bonavida B, Berenson JR
Blood, 2007-03-16;110(1):287-95.
Species: Human
Sample Types: Serum, Whole Cells
Applications: ELISA Development, ICC
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