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Interactive Pathways & Processes

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Resting Platelet Immune, Peptide, and Other Receptors

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Immune Receptors

C1q R1/CD93

Calreticulin

CD21

CD72

DC-SIGN/CD209

Fc gamma RIIA/CD32a

LRRC32/GARP

RAGE

Siglec-7/CD328

SLAM/CD150

CD84/SLAMF5

TLR1,2,4,6

TREML1/TLT1

Cytokine and Peptide Receptors

BAMBI/NMA

CCR1,2,3,4

CX3CR1

CXCR4 6

IGF-I R

Insulin R/CD220

LAP (TGF-beta)

PDGF R alpha, beta

Thrombopoietin R/Tpo R

TNF RI, RII

TSLP R

V1a Vasopressin R

VIP R1/VPAC1

Other Receptors

CXADR

DCBLD2/ESDN

DEP-1/CD148

DNAM-1/CD226

EMMPRIN/CD147

Glut3

LOX-1/OLR1

NHE1/SLC9A1

Orai1

PAR1,3,4

PEAR1

Plexin B1

Prohibitin

Semaphorin 4D/CD100

STIM1

Resting Platelet Immune, Peptide, and Other Receptors

Overview of Immune, Peptide, and Other Receptors on Resting Platelets

Platelet activation can be accelerated by growth factors, immunoglobulin complexes, microbial components, peptide hormones, and thrombin. These and other ligands promote platelet activation through the chemokine, growth factor, C-type lectin, PAR, TLR, complement, and SLAM receptor families. Activation through these receptors contributes to platelet adhesion and enhances coagulation and inflammatory activation.

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