Neurotrophin/Trk Family
The neurotrophin family is comprised of at least four proteins including NGF, BDNF, NT-3, and NT-4/5. These secreted cytokines are synthesized as prepropeptides that are proteolytically processed to generate active propeptides and mature protein homodimers. Mature NT-4 also forms heterodimers with BDNF or NT-3. Neurotrophins induce dimerization and activation of the Trk family of receptors and promote the development and survival of selected peripheral and CNS neurons.
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Neurotrophin/Trk Family Receptors
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Neurotrophin/Trk Family Signaling Molecules
- Akt
- Akt1
- Akt2
- Akt3
- DOCK3
- Endophilin A1/SH3GL2
- Endophilin B1/Bif-1
- Endophilin B1/B2
- ERK1/ERK2
- ERK1
- ERK2
- ERK3
- ERK4
- ERK5/BMK1
- JNK
- JNK1/JNK2
- JNK1
- JNK2
- JNK3
- NFkB1
- NFkB2
- NRAGE
- p38
- p38 alpha
- p38 beta/MAPK11
- p38 gamma
- p38 delta
- PI 3-Kinase p55 gamma
- PI 3-Kinase p85 alpha
- PI 3-Kinase p110 beta
- PI 3-Kinase p110 gamma
- PI 3-Kinase p110 delta
- PIK3CA
- PLC-beta 1
- PLC-beta 3
- PLC-beta 4
- PLC-gamma 1
- PLC-gamma 2
- PLC-delta 3
- Ras
- Ras-GAP
- TACE/ADAM17
- TRAF-6