Autophagy

Autophagy is the biological process in which endogenous proteins and damaged organelles are degraded by cellular self-digestion. R&D Systems offers quality products for the study of several autophagy-related proteins. ATG4A and ATG4B (Autophagy related protein 4 homolog A/B; also Autophagin 2) are 50 kDa cytosolic cysteine proteases mostly found in skeletal muscle and brain. Beclin1 (Bcl-2 interacting coiled-coil protein, also known as ATG6) induces autophagy as part of a lipid-kinase complex that includes UVRAG and PI3. In addition, ubiquitously expressed LAMP (lysosomal associated membrane protein) is involved in autophagy and may bind selectins on the cell surface.