WH-4-023
Chemical Name: 2,6-Dimethylphenyl-N-(2,4-dimethoxyphenyl)-N-[2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]carbamate
Purity: ≥98%
Biological Activity
WH-4-023 is a potent and selective Lck and Src inhibitor (IC50 values are 2 and 6 nM respectively). Exhibits >300-fold selectivity against p38α and KDR. Also potently inhibits SIK (IC50 values are 10, 22 and 60 nM for SIK 1, 2 and 3 respectively) and displays selectivity over a range of closely related kinases. Supports self-renewal of naive hESCs in combination with PD 0325901, CHIR 99021 and SB 590885.External Portal Information
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of WH-4-023 is reviewed on the chemical probes website.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Systematic identification of culture conditions for induction and maintenance of naive human pluripotency.
Theunissen et al.
Cell Stem Cell, 2014;15:471 -
Phosphorylation of CRTC3 by the salt-inducible kinases controls the interconversion of classically activated and regulatory macrophages.
Clark et al.
Proc.Natl.Acad.Sci.U.S.A., 2012;109:16986 -
Novel 2-aminopyrimidine carbamates as potent and orally active inhibitors of Lck: synthesis, SAR, and in vivo antiinflammatory activity.
Martin et al.
J.Med.Chem., 2006;49:4981
Product Datasheets
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Citations for WH-4-023
The citations listed below are publications that use Tocris products. Selected citations for WH-4-023 include:
3 Citations: Showing 1 - 3
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Species origin of exogenous transcription factors affects the activation of endogenous pluripotency markers and signaling pathways of porcine induced pluripotent stem cells.
Authors: Rongfeng Et al.
Front Cell Dev Biol 2023;11:1196273
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Establishment of porcine and human expanded potential stem cells.
Authors: Gao Et al.
Nat Cell Biol 2019;21:687
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Pluripotent state transitions coordinate morphogenesis in mouse and human embryos.
Authors: Shahbazi Et al.
Nature 2017;552:239
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