SB 590885
Chemical Name: 5-[2-[4-[2-(Dimethylamino)ethoxy]phenyl]-5-(4-pyridinyl)-1H-imidazol-4-yl]-2,3-dihydro-1H-inden-1-one oxime
Purity: ≥98%
Biological Activity
SB 590885 is a potent B-Raf inhibitor (Kd = 0.3 nM). Selective for B-Raf against 46 other kinases (Ki app values are 0.16 and 1.72 nM for B-Raf and c-Raf respectively). Decreases anchorage-independent growth of melanoma cell lines. Inhibits ERK phosphorylation and proliferation in tumor cells expressing B-RafV600E. The compound can be used in protocols for the chemical reprogramming of somatic cells to iPSCs.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
-
Drug-based modulation of endogenous stem cells promotes functional remyelination in vivo.
Najm F, Madhavan M, Zaremba A, Shick E, Karl R, Factor D, Miller T, Nevin Z, Kantor C, Sargent A, Quick K, Schlatzer D, Tang H, Papoian R, Brimacombe K, Shen M, Boxer M, Jadhav A, Robinson A, Podojil J, Miller S, Miller R, Tesar P
Nature, 2015;522(7555):216-20. -
PRC2 specifies ectoderm lineages and maintains pluripotency in primed but not na�ve ESCs
Y Shan, Z Liang, Q Xing, T Zhang, B Wang, S Tian, W Huang, Y Zhang, J Yao, Y Zhu, K Huang, Y Liu, X Wang, Q Chen, J Zhang, B Shang, S Li, X Shi, B Liao, C Zhang, K Lai, X Zhong, X Shu, J Wang, H Yao, J Chen, D Pei, G Pan
Nat Commun, 2017;8(1):672. -
BMI1 enables interspecies chimerism with human pluripotent stem cells
K Huang, Y Zhu, Y Ma, B Zhao, N Fan, Y Li, H Song, S Chu, Z Ouyang, Q Zhang, Q Xing, C Lai, N Li, T Zhang, J Gu, B Kang, Y Shan, K Lai, W Huang, Y Mai, Q Wang, J Li, A Lin, Y Zhang, X Zhong, B Liao, L Lai, J Chen, D Pei, G Pan
Nat Commun, 2018;9(1):4649. -
Unique molecular events during reprogramming of human somatic cells to induced pluripotent stem cells (iPSCs) at na�ve state
Y Wang, C Zhao, Z Hou, Y Yang, Y Bi, H Wang, Y Zhang, S Gao
Elife, 2018;7(0):. -
Endophilin marks and controls a clathrin-independent endocytic pathway.
Boucrot E, Ferreira A, Almeida-Souza L, Debard S, Vallis Y, Howard G, Bertot L, Sauvonnet N, McMahon H
Nature, 2015;517(7535):460-5. -
Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885.
King et al.
Cancer Res., 2006;66:11100 -
The identification of potent and selective imidazole-based inhibitors of B-Raf kinase.
Takle et al.
Bioorg.Med.Chem.Lett., 2006;16:378 -
Hominoid-Specific Transposable Elements and KZFPs Facilitate Human Embryonic Genome Activation and Control Transcription in Naive Human ESCs
J Pontis, E Planet, S Offner, P Turelli, J Duc, A Coudray, TW Theunissen, R Jaenisch, D Trono
Cell Stem Cell, 2019;0(0):. -
Capturing human trophoblast development with naive pluripotent stem cells in�vitro
S Io, M Kabata, Y Iemura, K Semi, N Morone, A Minagawa, B Wang, I Okamoto, T Nakamura, Y Kojima, C Iwatani, H Tsuchiya, B Kaswandy, E Kondoh, S Kaneko, K Woltjen, M Saitou, T Yamamoto, M Mandai, Y Takashima
Cell Stem Cell, 2021;28(6):1023-1039.e13.
Product Datasheets
Reconstitution Calculator
Molarity Calculator
Citations for SB 590885
The citations listed below are publications that use Tocris products. Selected citations for SB 590885 include:
3 Citations: Showing 1 - 3
-
Drug-based modulation of endogenous stem cells promotes functional remyelination in vivo.
Authors: Najm Et al.
PLoS One 2015;522:216
-
Resistance to vemurafenib resulting from a novel mutation in the BRAFV600E kinase domain.
Authors: Wagenaar Et al.
Pigment Cell Melanoma Res 2014;27:124
-
A modified HSP70 inhibitor shows broad activity as an anticancer agent.
Authors: Balaburski Et al.
Mol Cancer Res 2013;11:219
FAQs
No product specific FAQs exist for this product, however you may
View all Small Molecule FAQsReviews for SB 590885
Average Rating: 5 (Based on 1 Review)
Have you used SB 590885?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Filter by: