TCN 201

Biological Activity

Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. Potentiation of Synaptic GluN2B NMDAR Currents by Fyn Kinase Is Gated through BDNF-Mediated Disinhibition in Spinal Pain Processing
   
   Cell Rep, 2016;17(10):2753-2765.
2. Subtype selective NMDA receptor antagonists induce recovery of synapses lost following exposure to HIV-1 Tat.
   Shin et al.
   Br.J.Pharmacol., 2011;166:1002
3. TCN 201 selectively blocks GluN2A-containing NMDARs in a GluN1 co-agonist dependent but non-competitive manner.
   Edman et al.
   Neuropharmacology, 2012;63:441
4. Subunit-selective allosteric inhibition of glycine binding to NMDA receptors.
   Hansen et al.
   J.Neurosci., 2012;32:6197
5. Reinstatement of nicotine seeking is mediated by glutamatergic plasticity.
   Gipson et al.
   Proc.Natl.Acad.Sci.U S A [Epub ahead of print], 2013;
6. Identification and characterization of novel NMDA receptor antagonists selective for NR2A- over NR2B-containing receptors.
   Bettini et al.
   J.Pharm.Exp.Ther., 2010;335:644
7. Hevin/Sparcl1 drives pathological pain through spinal cord astrocyte and NMDA receptor signaling
   G Chen, J Xu, H Luo, X Luo, SK Singh, JJ Ramirez, ML James, JP Mathew, M Berger, C Eroglu, RR Ji
   JCI Insight, 2022;7(23):.

Product Datasheets