Home / Smoothened Receptor Agonists / SAG dihydrochloride

SAG dihydrochloride

Catalog #: 6390
3 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6390/1
6390/10
SAG dihydrochloride | CAS No. 2702366-44-5 | Smoothened Receptor Agonists
1 Image
Description: Dihydrochloride salt of SAG; Smo receptor agonist

Chemical Name: 3-Chloro-N-[trans-4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]benzo[b]thiophene-2-carboxamide dihydrochloride

Purity: ≥98%

Product Details
Citations (3)
Supplemental Products
Reviews
Biological Activity Technical Data Product Datasheets Calculators

Biological Activity

SAG dihydrochloride is a water-soluble dihydrochloride salt of SAG (Cat. No. 4366). SAG is a potent Smoothened (Smo) receptor agonist (Kd = 59 nM); antagonizes Cyclopamine (Cat. No. 1623) action at the Smo receptor. SAG potently activates the Hedgehog signaling pathway in Shh-light 2 cells (EC50 ~ 3 nM) and induces pathway activation independently of Ptch proteins. SAG is a putative inhibitor of a cellular component required for Hedgehog signaling and also enhances neuronal differentiation of iPSCs into dopaminergic neurons. The compound can be used in protocols for the chemical reprogramming of somatic cells to iPSCs.

Technical Data

M.Wt:
562.98
Formula:
C28H28ClN3OS.2HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2702366-44-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

COA view current batch
Or select another batch:
View Batch
SDS
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for SAG dihydrochloride

The citations listed below are publications that use Tocris products. Selected citations for SAG dihydrochloride include:

3 Citations: Showing 1 - 3

  1. Population-scale single-cell RNA-seq profiling across dopaminergic neuron differentiation.
    Authors: Madeline A Et al.
    Nat Genet  2021;53:304-312
  2. HDL inhibits endoplasmic reticulum stress-induced apoptosis of pancreatic β-cells in vitro by activation of Smoothened.
    Authors: Lucia Et al.
    J Lipid Res  2020;61:492-504
  3. Trisomy 21 Represses Cilia Formation and Function.
    Authors: Joaquin M Et al.
    Dev Cell  2018;46:641-650.e6

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs
Loading...

Reviews for SAG dihydrochloride

There are currently no reviews for this product. Be the first to review SAG dihydrochloride and earn rewards!

Have you used SAG dihydrochloride?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.