Home / Hedgehog Signaling Inhibitors / Cyclopamine

Cyclopamine

Catalog #: 1623
8 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
1623/1
Cyclopamine | CAS No. 4449-51-8 | Hedgehog Signaling Inhibitors
1 Image
Description: Inhibitor of Hedgehog (Hh) signaling

Chemical Name: (2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,11bR)-1,2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11,11a,11b-Octadecahydro-3',6',10,11b-tetramethylspiro[9H-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-3-ol

Purity: ≥97%

Product Details
Citations (8)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Cyclopamine is an inhibitor of hedgehog (Hh) signaling, likely via direct inhibition of Smoothened, the accessory protein to the putative Hh receptor Patched. Anticancer and teratogenic in vivo. Depletes stem-like cancer cells in glioblastoma and blocks tumor engraftment. Can also be used to induce differentiation of human embryonic stem cells (hESCs) into hormone-expressing endocrine cells.

Technical Data

M.Wt:
411.63
Formula:
C27H41NO2
Solubility:
Soluble to 5 mM in ethanol
Purity:
≥97%
Storage:
Desiccate at -20°C
CAS No:
4449-51-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Integration of Shh and Fgf signaling in controlling Hox gene expression in cultured limb cells
    AR Rodrigues, N Yakushiji-, Y Atsuta, G Andrey, P Schorderet, D Duboule, CJ Tabin
    Proc. Natl. Acad. Sci. U.S.A, 2017;0(0):.
  2. Differentiation of Human Pluripotent Stem Cells into Colonic Organoids via Transient Activation of BMP Signaling
    JO Múnera, N Sundaram, SA Rankin, D Hill, C Watson, M Mahe, JE Vallance, NF Shroyer, KL Sinagoga, A Zarzoso-La, JR Hudson, JC Howell, P Chatuvedi, JR Spence, JM Shannon, AM Zorn, MA Helmrath, JM Wells
    Cell Stem Cell, 2017;0(0):.
  3. Regulation and function of immunosuppressive molecule human leukocyte antigen G5 in human bone tissue.
    Deschaseaux F, Gaillard J, Langonne A, Chauveau C, Naji A, Bouacida A, Rosset P, Heymann D, De Pinieux G, Rouas-Freiss N, Sensebe L
    FASEB J, 2013;27(8):2977-87.
  4. Regulation of endodermal differentiation of human embryonic stem cells through integrin-ECM interactions.
    Brafman D, Phung C, Kumar N, Willert K
    Cell Death Differ, 2013;20(3):369-81.
  5. Endogenously produced Indian Hedgehog regulates TGFbeta-driven chondrogenesis of human bone marrow stromal/stem cells.
    Handorf A, Chamberlain C, Li W
    Stem Cells Dev, 2015;24(8):995-1007.
  6. Cyclopamine-mediated hedgehog pathway inhibition depletes stem-like cancer cells in glioblastoma.
    Bar et al.
    Stem Cells, 2007;25:2524
  7. Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells.
    D'Amour et al.
    Nat.Biotechnol., 2006;24:1392
  8. Inhibition of hedgehog signaling by direct binding of cyclopamine to smoothened.
    Chen et al.
    Genes Dev., 2002;16:2743
  9. Cancer: a twist in a hedgehog's tale.
    Scott
    Nature, 2003;425:780

Product Datasheets

COA view current batch
Or select another batch:
View Batch
SDS
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for Cyclopamine

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for Cyclopamine

There are currently no reviews for this product. Be the first to review Cyclopamine and earn rewards!

Have you used Cyclopamine?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.