Recombinant Human GDNF Protein

Human spinal interneurons repair the injured spinal cord through synaptic integration
Authors: Zholudeva, LV;Fortino, T;Agrawal, A;Vila, OF;Williams, M;McDevitt, T;Lane, MA;Srivastava, D;
bioRxiv : the preprint server for biology
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Secretome Analyses Identify FKBP4 as a GBA1-Associated Protein in CSF and iPS Cells from Parkinson's Disease Patients with GBA1 Mutations
Authors: Kojima, R;Paslawski, W;Lyu, G;Arenas, E;Zhang, X;Svenningsson, P;
International journal of molecular sciences
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Enhanced production of mesencephalic dopaminergic neurons from lineage-restricted human undifferentiated stem cells
Authors: Maimaitili, M;Chen, M;Febbraro, F;Ucuncu, E;Kelly, R;Niclis, JC;Christiansen, JR;Mermet-Joret, N;Niculescu, D;Lauritsen, J;Iannielli, A;Klæstrup, IH;Jensen, UB;Qvist, P;Nabavi, S;Broccoli, V;Nykjær, A;Romero-Ramos, M;Denham, M;
Nature communications
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Negative modulation of mitochondrial calcium uniporter complex protects neurons against ferroptosis
Authors: Marmolejo-Garza, A;Krabbendam, IE;Luu, MDA;Brouwer, F;Trombetta-Lima, M;Unal, O;O'Connor, SJ;Majerníková, N;Elzinga, CRS;Mammucari, C;Schmidt, M;Madesh, M;Boddeke, E;Dolga, AM;
Cell death & disease
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

CLIP-Seq analysis enables the design of protective ribosomal RNA bait oligonucleotides against C9ORF72 ALS/FTD poly-GR pathophysiology
Authors: Ortega, JA;Sasselli, IR;Boccitto, M;Fleming, AC;Fortuna, TR;Li, Y;Sato, K;Clemons, TD;Mckenna, ED;Nguyen, TP;Anderson, EN;Asin, J;Ichida, JK;Pandey, UB;Wolin, SL;Stupp, SI;Kiskinis, E;
Science advances
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Essential Role of BMP4 Signaling in the Avian Ceca in Colorectal Enteric Nervous System Development
Authors: Kovács, T;Halasy, V;Peth?, C;Sz?cs, E;Soós, Á;Dóra, D;de Santa Barbara, P;Faure, S;Stavely, R;Goldstein, AM;Nagy, N;
International journal of molecular sciences
Species: Chicken
Sample Types: Whole Tissue
Applications: Bioassay

Multiomic prediction of therapeutic targets for human diseases associated with protein phase separation
Authors: Lim, CM;González Díaz, A;Fuxreiter, M;Pun, FW;Zhavoronkov, A;Vendruscolo, M;
Proceedings of the National Academy of Sciences of the United States of America
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Identification of the bacterial metabolite aerugine as potential trigger of human dopaminergic neurodegeneration
Authors: Ückert, AK;Rütschlin, S;Gutbier, S;Wörz, NC;Miah, MR;Martins, AC;Hauer, I;Holzer, AK;Meyburg, B;Mix, AK;Hauck, C;Aschner, M;Böttcher, T;Leist, M;
Environment international
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Analysis of proteome-wide degradation dynamics in ALS SOD1 iPSC-derived patient neurons reveals disrupted VCP homeostasis
Authors: Tsioras, K;Smith, KC;Edassery, SL;Garjani, M;Li, Y;Williams, C;McKenna, ED;Guo, W;Wilen, AP;Hark, TJ;Marklund, SL;Ostrow, LW;Gilthorpe, JD;Ichida, JK;Kalb, RG;Savas, JN;Kiskinis, E;
Cell reports
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

Dual-specificity protein phosphatase 6 (DUSP6) overexpression reduces amyloid load and improves memory deficits in male 5xFAD mice
Authors: Pan, AL;Audrain, M;Sakakibara, E;Joshi, R;Zhu, X;Wang, Q;Wang, M;Beckmann, ND;Schadt, EE;Gandy, S;Zhang, B;Ehrlich, ME;Salton, SR;
bioRxiv : the preprint server for biology
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Loss of function of the ALS-associated NEK1 kinase disrupts microtubule homeostasis and nuclear import
Authors: Mann, JR;McKenna, ED;Mawrie, D;Papakis, V;Alessandrini, F;Anderson, EN;Mayers, R;Ball, HE;Kaspi, E;Lubinski, K;Baron, DM;Tellez, L;Landers, JE;Pandey, UB;Kiskinis, E;
Science advances
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Modeling idiopathic autism in forebrain organoids reveals an imbalance of excitatory cortical neuron subtypes during early neurogenesis
Authors: Jourdon, A;Wu, F;Mariani, J;Capauto, D;Norton, S;Tomasini, L;Amiri, A;Suvakov, M;Schreiner, JD;Jang, Y;Panda, A;Nguyen, CK;Cummings, EM;Han, G;Powell, K;Szekely, A;McPartland, JC;Pelphrey, K;Chawarska, K;Ventola, P;Abyzov, A;Vaccarino, FM;
Nature neuroscience
Species: Human
Sample Types: Organoids
Applications: Bioassay

Monomerization of TDP-43 is a key determinant for inducing TDP-43 pathology in amyotrophic lateral sclerosis
Authors: Oiwa, K;Watanabe, S;Onodera, K;Iguchi, Y;Kinoshita, Y;Komine, O;Sobue, A;Okada, Y;Katsuno, M;Yamanaka, K;
Science advances
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Decoding the spermatogonial stem cell niche under physiological and recovery conditions in adult mice and humans
Authors: Jin, C;Wang, Z;Li, P;Tang, J;Jiao, T;Li, Y;Ou, J;Zou, D;Li, M;Mang, X;Liu, J;Ma, Y;Wu, X;Shi, J;Chen, S;He, M;Lu, Y;Zhang, N;Miao, S;Sun, F;Wang, L;Li, K;Yu, J;Song, W;
Science advances
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Patient iPSC models reveal glia-intrinsic phenotypes in multiple sclerosis
Authors: Clayton, BLL;Barbar, L;Sapar, M;Rusielewicz, T;Kalpana, K;Migliori, B;NYSCF Global Stem Cell Array® Team, ;Paull, D;Brenner, K;Moroziewicz, D;Sand, IK;Casaccia, P;Tesar, PJ;Fossati, V;
bioRxiv : the preprint server for biology
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Proteomic responses in the human dopaminergic LUHMES cell line to imidacloprid and its metabolites imidacloprid-olefin and desnitro-imidacloprid
Authors: Sinclair, P;Hakeem, J;Kumar, SG;Loser, D;Dixit, K;Leist, M;Kraushaar, U;Kabbani, N;
Pesticide biochemistry and physiology
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Cross-site reproducibility of human cortical organoids reveals consistent cell type composition and architecture
Authors: Glass, MR;Waxman, EA;Yamashita, S;Lafferty, M;Beltran, A;Farah, T;Patel, NK;Matoba, N;Ahmed, S;Srivastava, M;Drake, E;Davis, LT;Yeturi, M;Sun, K;Love, MI;Hashimoto-Torii, K;French, DL;Stein, JL;
bioRxiv : the preprint server for biology
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Specific vulnerability of iPSC-derived motor neurons with TDP-43 gene mutation to oxidative stress
Authors: Onda-Ohto, A;Hasegawa-Ogawa, M;Matsuno, H;Shiraishi, T;Bono, K;Hiraki, H;Kanegae, Y;Iguchi, Y;Okano, HJ;
Molecular brain
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Dissecting the spermatogonial stem cell niche using spatial transcriptomics
Authors: Rajachandran, S;Zhang, X;Cao, Q;Caldeira-Brant, AL;Zhang, X;Song, Y;Evans, M;Bukulmez, O;Grow, EJ;Nagano, M;Orwig, KE;Chen, H;
Cell reports
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

Deregulation of mTORC1-TFEB axis in human iPSC model of GBA1-associated Parkinson's disease
Authors: Mubariz, F;Saadin, A;Lingenfelter, N;Sarkar, C;Banerjee, A;Lipinski, MM;Awad, O;
Frontiers in neuroscience
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

IPSC-Derived Sensory Neurons Directing Fate Commitment of Human BMSC-Derived Schwann Cells: Applications in Traumatic Neural Injuries
Authors: Tam, KW;Wong, CY;Wu, KL;Lam, G;Liang, X;Wong, WT;Li, MT;Liu, WY;Cai, S;Shea, GK;Shum, DK;Chan, YS;
Cells
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Molecular and Functional Characterization of Different BrainSphere Models for Use in Neurotoxicity Testing on Microelectrode Arrays
Authors: Hartmann, J;Henschel, N;Bartmann, K;D�nmez, A;Brockerhoff, G;Koch, K;Fritsche, E;
Cells
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

High-content synaptic phenotyping in human cellular models reveals a role for BET proteins in synapse assembly
Authors: MH Berryer, G Rizki, A Nathanson, JA Klein, D Trendafilo, SG Susco, D Lam, A Messana, KM Holton, KW Karhohs, BA Cimini, K Pfaff, AE Carpenter, LL Rubin, LE Barrett
Elife, 2023-04-21;12(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Lovastatin promotes the self-renewal of murine and primate spermatogonial stem cells
Authors: C Li, Z Yao, L Ma, X Song, W Wang, C Wan, S Ren, D Chen, Y Zheng, YT Zhu, G Chang, S Wu, K Miao, F Luo, XY Zhao
Stem Cell Reports, 2023-04-11;18(4):969-984.
Species: Human
Sample Types: Whole Cell
Applications: Bioassay

Astrocytes mediate cell non-autonomous correction of aberrant firing in human FXS neurons
Authors: SD Sharma, BK Reddy, R Pal, TE Ritakari, JD Cooper, BT Selvaraj, PC Kind, S Chandran, DJA Wyllie, S Chattarji
Cell Reports, 2023-04-04;42(4):112344.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Non-muscle MYH10/myosin IIB recruits ESCRT-III to participate in autophagosome closure to maintain neuronal homeostasis
Authors: YW Jun, S Lee, BK Ban, JA Lee, FB Gao
Autophagy, 2023-02-27;0(0):1-17.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

A Potent and Selective CDKL5/GSK3 Chemical Probe is Neuroprotective
Authors: HW Ong, Y Liang, W Richardson, ER Lowry, CI Wells, X Chen, M Silvestre, K Dempster, JA Silvaroli, JL Smith, H Wichterle, NS Pabla, SK Ultanir, AN Bullock, DH Drewry, AD Axtman
bioRxiv : the preprint server for biology, 2023-02-10;0(0):.
Species: Human
Sample Types: Organoid
Applications: Bioassay

SYF2 suppression mitigates neurodegeneration in models of diverse forms of ALS
Authors: GR Linares, Y Li, WH Chang, J Rubin-Sigl, S Mendonca, S Hong, Y Eoh, W Guo, YH Huang, J Chang, S Tu, N Dorjsuren, M Santana, ST Hung, J Yu, J Perez, M Chickering, TY Cheng, CC Huang, SJ Lee, HJ Deng, KT Bach, K Gray, V Subramanya, J Rosenfeld, SV Alworth, H Goodarzi, JK Ichida
Cell Stem Cell, 2023-02-02;30(2):171-187.e14.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Artificial extracellular matrix scaffolds of mobile molecules enhance maturation of human stem cell-derived neurons
Authors: Z Álvarez, JA Ortega, K Sato, IR Sasselli, AN Kolberg-Ed, R Qiu, KA Marshall, TP Nguyen, CS Smith, KA Quinlan, V Papakis, Z Syrgiannis, NA Sather, C Musumeci, E Engel, SI Stupp, E Kiskinis
Cell Stem Cell, 2023-01-12;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Astrocytic cell adhesion genes linked to schizophrenia correlate with synaptic programs in neurons
Authors: O Pietiläine, A Trehan, D Meyer, J Mitchell, M Tegtmeyer, V Valakh, H Gebre, T Chen, E Vartiainen, SL Farhi, K Eggan, SA McCarroll, R Nehme
Cell Reports, 2023-01-12;42(1):111988.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Increased post-mitotic senescence in aged human neurons is a pathological feature of Alzheimer's disease
Authors: JR Herdy, L Traxler, RK Agarwal, L Karbacher, JCM Schlachetz, L Boehnke, D Zangwill, D Galasko, CK Glass, J Mertens, FH Gage
Cell Stem Cell, 2022-12-01;29(12):1637-1652.e6.
Species: Human
Sample Types: Transduced Whole Cells
Applications: Bioassay

A reference human induced pluripotent stem cell line for large-scale collaborative studies
Authors: CB Pantazis, A Yang, E Lara, JA McDonough, C Blauwendra, L Peng, H Oguro, J Kanaujiya, J Zou, D Sebesta, G Pratt, E Cross, J Blockwick, P Buxton, L Kinner-Bib, C Medura, C Tompkins, S Hughes, M Santiana, F Faghri, MA Nalls, D Vitale, S Ballard, YA Qi, DM Ramos, KM Anderson, J Stadler, P Narayan, J Papademetr, L Reilly, MP Nelson, S Aggarwal, LU Rosen, P Kirwan, V Pisupati, SL Coon, SW Scholz, T Priebe, M Öttl, J Dong, M Meijer, LJM Janssen, VS Lourenco, R van der Ka, D Crusius, D Paquet, AC Raulin, G Bu, A Held, BJ Wainger, RMC Gabriele, JM Casey, S Wray, D Abu-Bonsra, CL Parish, MS Beccari, DW Cleveland, E Li, IVL Rose, M Kampmann, C Calatayud, P Verstreken, L Heinrich, MY Chen, B Schüle, D Dou, ELF Holzbaur, MC Zanellati, R Basundra, M Deshmukh, S Cohen, R Khanna, M Raman, ZS Nevin, M Matia, J Van Lent, V Timmerman, BR Conklin, K Johnson Ch, K Zhang, S Funes, DA Bosco, L Erlebach, M Welzer, D Kronenberg, G Lyu, E Arenas, E Coccia, L Sarrafha, T Ahfeldt, JC Marioni, WC Skarnes, MR Cookson, ME Ward, FT Merkle
Cell Stem Cell, 2022-12-01;29(12):1685-1702.e22.
Species: Human
Sample Types: Organoid
Applications: Bioassay

The monoculture of cord-blood-derived CD34+ cells by an automated, membrane-based dynamic perfusion system with a novel cytokine cocktail
Authors: M Jones, A Cunningham, N Frank, D Sethi
Stem Cell Reports, 2022-11-03;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Genome-wide CRISPR screen reveals v-ATPase as a drug target to lower levels of ALS protein ataxin-2
Authors: G Kim, L Nakayama, JA Blum, T Akiyama, S Boeynaems, M Chakrabort, J Couthouis, E Tassoni-Ts, CM Rodriguez, MC Bassik, AD Gitler
Cell Reports, 2022-10-25;41(4):111508.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Modeling gene � environment interactions in PTSD using human neurons reveals diagnosis-specific glucocorticoid-induced gene expression
Authors: C Seah, MS Breen, T Rusielewic, HN Bader, C Xu, CJ Hunter, B McCarthy, PJM Deans, M Chattopadh, J Goldberg, F Desarnaud, I Makotkine, JD Flory, LM Bierer, M Staniskyte, NYSCF Glob, SA Noggle, LM Huckins, D Paull, KJ Brennand, R Yehuda
Nature Neuroscience, 2022-10-20;25(11):1434-1445.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Transcriptional dynamics of murine motor neuron maturation in vivo and in vitro
Authors: T Patel, J Hammelman, S Aziz, S Jang, M Closser, TL Michaels, JA Blum, DK Gifford, H Wichterle
Nature Communications, 2022-09-15;13(1):5427.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

Alpha synuclein determines ferroptosis sensitivity in dopaminergic neurons via modulation of ether-phospholipid membrane composition
Authors: L Mahoney-Sa, H Bouchaoui, I Boussaad, A Jonneaux, K Timmerman, O Berdeaux, S Ayton, R Krüger, JA Duce, D Devos, JC Devedjian
Cell Reports, 2022-08-23;40(8):111231.
Species: Human
Sample Types: Cell Culture Supernates
Applications: Bioassay

Human iPSC-derived astrocytes generated from donors with globoid cell leukodystrophy display phenotypes associated with disease
Authors: R Lieberman, LK Cortes, G Gao, H Park, B Wang, PL Jones, RB Hunter, JP Leonard, RH Barker
PLoS ONE, 2022-08-03;17(8):e0271360.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Cellular analysis of SOD1 protein-aggregation propensity and toxicity: a case of ALS with slow progression harboring homozygous SOD1-D92G mutation
Authors: M Sawamura, K Imamura, R Hikawa, T Enami, A Nagahashi, H Yamakado, H Ichijo, T Fujisawa, H Yamashita, S Minamiyama, M Kaido, H Wada, M Urushitani, H Inoue, N Egawa, R Takahashi
Scientific Reports, 2022-07-25;12(1):12636.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Long-Term Treatment with Bortezomib Induces Specific Methylation Changes in Differentiated Neuronal Cells
Authors: K ?uczkowska, O Taryma-Le?, J Bi?kowski, KE Soko?owska, D Strapagiel, J Jarczak, E Paczkowska, B Machali?sk, TK Wojdacz
Cancers, 2022-07-13;14(14):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

G2019S LRRK2 Mutation Enhances MPP+-Induced Inflammation of Human Induced Pluripotent Stem Cells-Differentiated Dopaminergic Neurons
Authors: Y Chen, Q Yin, XY Cheng, JR Zhang, H Jin, K Li, CJ Mao, F Wang, HZ Bei, CF Liu
Frontiers in Neuroscience, 2022-07-06;16(0):947927.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Pharmacotherapy alleviates pathological changes in human direct reprogrammed neuronal cell model of myotonic dystrophy type 1
Authors: MK Eltahir, M Nakamori, S Hattori, T Kimura, H Mochizuki, S Nagano
PLoS ONE, 2022-07-01;17(7):e0269683.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Physical and functional interactome atlas of human receptor tyrosine kinases.
Authors: Salokas K, Liu X, Ohman T, Chowdhury I, Gawriyski L, Keskitalo S, Varjosalo M
EMBO Rep, 2022-04-05;23(6):e54041.
Species: Human
Sample Types: Transfected Whole Cells
Applications: Bioassay

Specific Attenuation of Purinergic Signaling during Bortezomib-Induced Peripheral Neuropathy In Vitro
Authors: AK Holzer, I Suciu, C Karreman, T Goj, M Leist
International Journal of Molecular Sciences, 2022-03-29;23(7):.
Species: Human
Sample Types: Whole Cells
Applications: Differentiation, Differentiation

Pterostilbene in Combination With Mitochondrial Cofactors Improve Mitochondrial Function in Cellular Models of Mitochondrial Diseases
Authors: JM Suárez-Riv, CJ Pastor-Mal, A Romero-Gon, D Gómez-Fern, S Povea-Cabe, M Álvarez-Có, I Villalón-G, M Talaverón-, A Suárez-Car, M Munuera-Ca, JA Sánchez-Al
Frontiers in Pharmacology, 2022-03-18;13(0):862085.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Human Neurons Form Axon-Mediated Functional Connections with Human Cardiomyocytes in Compartmentalized Microfluidic Chip
Authors: M Häkli, S Jäntti, T Joki, L Sukki, K Tornberg, K Aalto-Setä, P Kallio, M Pekkanen-M, S Narkilahti
International Journal of Molecular Sciences, 2022-03-15;23(6):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Monitoring the interactions between alpha-synuclein and Tau in vitro and in vivo using bimolecular fluorescence complementation
Authors: L Torres-Gar, JM P Domingue, E Brandi, C Haikal, JM Mudannayak, IC Brás, E Gerhardt, W Li, A Svanbergss, TF Outeiro, GK Gouras, JY Li
Scientific Reports, 2022-02-22;12(1):2987.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Generation and characterization of motor neuron progenitors and motor neurons using metachromatic leukodystrophy-induced pluripotent stem cells
Authors: MA Hossain, M Hasegawa-O, Y Manome, M Igarashi, C Wu, K Suzuki, J Igarashi, T Iwamoto, HJ Okano, Y Eto
Oncogene, 2022-02-21;31(0):100852.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

A combined cell and gene therapy approach for homotopic reconstruction of midbrain dopamine pathways using human pluripotent stem cells
Authors: N Moriarty, CW Gantner, CPJ Hunt, CM Ermine, S Frausin, S Viventi, DA Ovchinniko, D Kirik, CL Parish, LH Thompson
Cell Stem Cell, 2022-02-17;29(3):434-448.e5.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Modeling axonal regeneration by changing cytoskeletal dynamics in stem cell-derived motor nerve organoids
Authors: WM Seo, J Yoon, JH Lee, Y Lee, H Lee, D Geum, W Sun, MR Song
Scientific Reports, 2022-02-08;12(1):2082.
Species: Human
Sample Types: Organoids
Applications: Bioassay

A kainic acid-induced seizure model in human pluripotent stem cell-derived cortical neurons for studying the role of IL-6 in the functional activity
Authors: R Mzezewa, J Lotila, H Kiiski, A Vinogradov, FE Kapucu, J Peltola, S Hagman, S Narkilahti
Stem Cell Research, 2022-01-17;60(0):102665.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Generation of a NES-mScarlet Red Fluorescent Reporter Human iPSC Line for Live Cell Imaging and Flow Cytometric Analysis and Sorting Using CRISPR-Cas9-Mediated Gene Editing
Authors: P Nouri, A Zimmer, S Brüggemann, R Friedrich, R Kühn, N Prakash
Cells, 2022-01-13;11(2):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

MGE-Like Neural Progenitor Cell Survival and Expression of Parvalbumin and Proenkephalin in a Jaundiced Rat Model of Kernicterus
Authors: FC Yang, JL Vivian, C Traxler, SM Shapiro, JA Stanford
Cell Transplantation, 2022-01-01;31(0):9636897221101.
Species: Human
Sample Types: Embryoid Bodies
Applications: Bioassay

Establishment of a human induced pluripotent stem cell neuronal model for identification of modulators of A53T alpha-synuclein levels and aggregation
Authors: C Vajhøj, B Schmid, A Alik, R Melki, K Fog, B Holst, TC Stummann
PLoS ONE, 2021-12-21;16(12):e0261536.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Tmem160 contributes to the establishment of discrete nerve injury-induced pain behaviors in male mice
Authors: D Segelcke, HK Fischer, M Hütte, S Dennerlein, F Benseler, N Brose, EM Pogatzki-Z, M Schmidt
Cell Reports, 2021-12-21;37(12):110152.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Reprogramming Human Adult Fibroblasts into GABAergic Interneurons
Authors: A Bruzelius, S Kidnapilla, J Drouin-Oue, T Stoker, RA Barker, D Rylander O
Cells, 2021-12-08;10(12):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Identification of ASCL1 as a determinant for human iPSC-derived dopaminergic neurons
Authors: AM Earley, LF Burbulla, D Krainc, R Awatramani
Scientific Reports, 2021-11-15;11(1):22257.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

An integrative proteomics method identifies a regulator of translation during stem cell maintenance and differentiation
Authors: P Sabatier, CM Beusch, AA Saei, M Aoun, N Moruzzi, A Coelho, N Leijten, M Nordenskjö, P Micke, D Maltseva, AG Tonevitsky, V Millischer, J Carlos Vil, S Kadekar, M Gaetani, K Altynbekov, A Kel, PO Berggren, O Simonson, KH Grinnemo, R Holmdahl, S Rodin, RA Zubarev
Nature Communications, 2021-11-12;12(1):6558.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

A C. elegans model of C9orf72-associated ALS/FTD uncovers a conserved role for eIF2D in RAN translation
Authors: Y Sonobe, J Aburas, G Krishnan, AC Fleming, G Ghadge, P Islam, EC Warren, Y Gu, MW Kankel, AEX Brown, E Kiskinis, TF Gendron, FB Gao, RP Roos, P Kratsios
Nature Communications, 2021-10-15;12(1):6025.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Transcriptional signatures in iPSC-derived neurons are reproducible across labs when differentiation protocols are closely matched
Authors: X Reed, MM Cobb, G Skinbinski, D Roosen, A Kaganovich, J Ding, S Finkbeiner, MR Cookson
Stem Cell Research, 2021-10-03;56(0):102558.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

Regulation of prefrontal patterning and connectivity by retinoic acid
Authors: M Shibata, K Pattabiram, B Lorente-Ga, D Andrijevic, SK Kim, N Kaur, SK Muchnik, X Xing, G Santpere, AMM Sousa, N Sestan
Nature, 2021-10-01;0(0):.
Species: Human, Primate
Sample Types: Cell Culture Supernates
Applications: Cell Culture

Alpha-Synuclein defects autophagy by impairing SNAP29-mediated autophagosome-lysosome fusion
Authors: Q Tang, P Gao, T Arzberger, M Höllerhage, J Herms, G Höglinger, T Koeglsperg
Cell Death & Disease, 2021-09-17;12(10):854.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

The intracellular milieu of Parkinson's disease patient brain cells modulates alpha-synuclein protein aggregation
Authors: N Gustavsson, E Savchenko, O Klementiev, L Roybon
Acta neuropathologica communications, 2021-09-16;9(1):153.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

RHOX10 drives mouse spermatogonial stem cell establishment through a transcription factor signaling cascade
Authors: K Tan, HW Song, MF Wilkinson
Cell Reports, 2021-07-20;36(3):109423.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Development of a physiologically relevant and easily scalable LUHMES cell-based model of G2019S LRRK2-driven Parkinson's disease
Authors: B Calamini, N Geyer, N Huss-Braun, A Bernhardt, V Harsany, P Rival, M Cindhuchao, D Hoffmann, S Gratzer
Disease Models & Mechanisms, 2021-06-11;14(6):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Human stem cells harboring a suicide gene improve the�safety and standardisation of neural transplants in Parkinsonian rats
Authors: IR de Luzy, KCL Law, N Moriarty, CPJ Hunt, JC Durnall, LH Thompson, A Nagy, CL Parish
Nature Communications, 2021-05-27;12(1):3275.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Co-development of central and peripheral neurons with trunk mesendoderm in human elongating multi-lineage organized gastruloids
Authors: ZT Olmsted, JL Paluh
Nature Communications, 2021-05-21;12(1):3020.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Constitutive activation of CTNNB1 results in a loss of spermatogonial stem cell activity in mice
Authors: A Boyer, X Zhang, A Levasseur, N Abou Nader, G St-Jean, MC Nagano, D Boerboom
PLoS ONE, 2021-05-20;16(5):e0251911.
Species: Transgenic Mouse
Sample Types: Whole Cells
Applications: Bioassay

Genoppi is an open-source software for robust and standardized integration of proteomic and genetic data
Authors: G Pintacuda, FH Lassen, YH Hsu, A Kim, JM Martín, E Malolepsza, JK Lim, N Fornelos, KC Eggan, K Lage
Nature Communications, 2021-05-10;12(1):2580.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Age-dependent instability of mature neuronal fate in induced neurons from Alzheimer's patients
Authors: J Mertens, JR Herdy, L Traxler, ST Schafer, JCM Schlachetz, L Böhnke, DA Reid, H Lee, D Zangwill, DP Fernandes, RK Agarwal, R Lucciola, L Zhou-Yang, L Karbacher, F Edenhofer, S Stern, S Horvath, ACM Paquola, CK Glass, SH Yuan, M Ku, A Szücs, LSB Goldstein, D Galasko, FH Gage
Cell Stem Cell, 2021-04-27;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Transcriptional networks identify synaptotagmin-like 3 as a regulator of cortical neuronal migration during early neurodevelopment
Authors: X Dong, L Yang, K Liu, X Ji, C Tang, W Li, L Ma, Y Mei, T Peng, B Feng, Z Wu, Q Tang, Y Gao, K Yan, W Zhou, M Xiong
Cell Reports, 2021-03-02;34(9):108802.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Regulation of host and virus genes by neuronal miR-138 favours herpes simplex virus 1 latency
Authors: B Sun, X Yang, F Hou, X Yu, Q Wang, HS Oh, P Raja, JM Pesola, EAH Vanni, S McCarron, J Morris-Lov, AHM Ng, GM Church, DM Knipe, DM Coen, D Pan
Nature Microbiology, 2021-02-08;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

A quantitative model of cellular decision making in direct neuronal reprogramming
Authors: A Merlevede, EM Legault, V Drugge, RA Barker, J Drouin-Oue, V Olariu
Scientific Reports, 2021-01-15;11(1):1514.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Development of a physiologically relevant and easily scalable LUHMES cell-based model of G2019S LRRK2 driven parkinson's disease
Authors: B Calamini, N Geyer, N Huss-Braun, A Bernhardt, V Harsany, P Rival, M Cindhuchao, D Hoffmann, S Gratzer
Disease Models & Mechanisms, 2021-01-01;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Melatonin Protects Goat Spermatogonial Stem Cells against Oxidative Damage during Cryopreservation by Improving Antioxidant Capacity and Inhibiting Mitochondrial Apoptosis Pathway
Authors: TY Feng, Q Li, F Ren, HM Xi, DL Lv, Y Li, JH Hu
Oxidative Medicine and Cellular Longevity, 2020-12-31;2020(0):5954635.
Species: Goat
Sample Types: Whole Cells
Applications: Bioassay

Plasticity of distal nephron epithelia from human kidney organoids enables the induction of ureteric tip and stalk
Authors: SE Howden, SB Wilson, E Groenewege, L Starks, TA Forbes, KS Tan, JM Vanslambro, EM Holloway, YH Chen, S Jain, JR Spence, MH Little
Cell Stem Cell, 2020-12-29;0(0):.
Species: Human
Sample Types: Transfected Whole Cells
Applications: Bioassay

Novel method to produce a layered 3D scaffold for human pluripotent stem cell-derived neuronal cells
Authors: L Honkamäki, T Joki, NA Grigoryev, K Levon, L Ylä-Outine, S Narkilahti
Journal of neuroscience methods, 2020-12-17;350(0):109043.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Human Pluripotent Stem Cell-Derived Kidney Organoids with Improved Collecting Duct Maturation and Injury Modeling
Authors: K Uchimura, H Wu, Y Yoshimura, BD Humphreys
Cell Reports, 2020-12-15;33(11):108514.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Aberrant interaction of FUS with the U1 snRNA provides a molecular mechanism of FUS induced amyotrophic lateral sclerosis
Authors: D Jutzi, S Campagne, R Schmidt, S Reber, J Mechtershe, F Gypas, C Schweingru, M Colombo, C von Schroe, FE Loughlin, A Devoy, E Hedlund, M Zavolan, FH Allain, MD Ruepp
Nature Communications, 2020-12-11;11(1):6341.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Induced Pluripotent Stem Cells to Understand Mucopolysaccharidosis. I: Demonstration of a Migration Defect in Neural Precursors
Authors: S Lito, A Sidibe, S Ilmjarv, P Burda, M Baumgartne, B Wehrle-Hal, KH Krause, A Marteyn
Cells, 2020-12-03;9(12):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Direct Conversion of Human Stem Cell-Derived Glial Progenitor Cells into GABAergic Interneurons
Authors: J Giacomoni, A Bruzelius, CA Stamouli, D Rylander O
Cells, 2020-11-10;9(11):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

RNA dependent suppression of C9orf72 ALS/FTD associated neurodegeneration by Matrin-3
Authors: N Ramesh, EL Daley, AM Gleixner, JR Mann, S Kour, D Mawrie, EN Anderson, J Kofler, CJ Donnelly, E Kiskinis, UB Pandey
Acta Neuropathol Commun, 2020-10-31;8(1):177.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

Amitriptyline interferes with autophagy-mediated clearance of protein aggregates via inhibiting autophagosome maturation in neuronal cells
Authors: Y Kwon, Y Bang, SH Moon, A Kim, HJ Choi
Cell Death Dis, 2020-10-17;11(10):874.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Direct Reprogramming of Human Fetal- and Stem Cell-Derived Glial Progenitor Cells into Midbrain Dopaminergic Neurons
Authors: S Nolbrant, J Giacomoni, DB Hoban, A Bruzelius, M Birtele, D Chandler-M, M Pereira, DR Ottosson, SA Goldman, M Parmar
Stem Cell Reports, 2020-09-24;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Defects in mRNA Translation in LRRK2-Mutant hiPSC-Derived Dopaminergic Neurons Lead to Dysregulated Calcium Homeostasis
Authors: JW Kim, X Yin, A Jhaldiyal, MR Khan, I Martin, Z Xie, T Perez-Rose, M Kumar, L Abalde-Atr, J Xu, L Chen, SM Eacker, DJ Surmeier, NT Ingolia, TM Dawson, VL Dawson
Cell Stem Cell, 2020-08-25;27(4):633-645.e7.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Modulation of Human Adipose Stem Cells' Neurotrophic Capacity Using a Variety of Growth Factors for Neural Tissue Engineering Applications: Axonal Growth, Transcriptional, and Phosphoproteomic Analyses In Vitro
Authors: KM Prautsch, A Schmidt, V Paradiso, DJ Schaefer, R Guzman, DF Kalbermatt, S Madduri
Cells, 2020-08-21;9(9):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay, Cell Culture

4-Phenylbutyrate ameliorates apoptotic neural cell death in Down syndrome by reducing protein aggregates
Authors: K Hirata, T Nambara, K Kawatani, N Nawa, H Yoshimatsu, H Kusakabe, K Banno, K Nishimura, M Ohtaka, M Nakanishi, H Taniguchi, H Arahori, K Wada, K Ozono, Y Kitabatake
Sci Rep, 2020-08-20;10(1):14047.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Developmental changes in the accessible chromatin, transcriptome and Ascl1-binding correlate with the loss in M�ller Glial regenerative potential
Authors: LS VandenBosc, SG Wohl, MS Wilken, M Hooper, C Finkbeiner, K Cox, L Chipman, TA Reh
Sci Rep, 2020-08-12;10(1):13615.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Robotic High-Throughput Biomanufacturing and Functional Differentiation of Human Pluripotent Stem Cells
Authors: CA Tristan, P Ormanoglu, J Slamecka, C Malley, PH Chu, VM Jovanovic, Y Gedik, C Bonney, E Barnaeva, J Braisted, SK Mallanna, D Dorjsuren, MJ Iannotti, TC Voss, S Michael, A Simeonov, I Singeç
bioRxiv, 2020-08-03;0(0):.
Species: Human
Sample Types: Organoid, Whole Cells
Applications: Bioassay

Expansion of Human iPSC-Derived Ureteric Bud Organoids with Repeated Branching Potential
Authors: SI Mae, M Ryosaka, S Sakamoto, K Matsuse, A Nozaki, M Igami, R Kabai, A Watanabe, K Osafune
Cell Rep, 2020-07-28;32(4):107963.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Maturational Changes in Mouse Cutaneous Touch and Piezo2-Mediated Mechanotransduction
Authors: N Michel, P Narayanan, O Shomroni, M Schmidt
Cell Rep, 2020-07-21;32(3):107912.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Cortical neurons derived from human pluripotent stem cells lacking FMRP display altered spontaneous firing patterns
Authors: S Das Sharma, R Pal, BK Reddy, BT Selvaraj, N Raj, KK Samaga, DJ Srinivasan, L Ornelas, D Sareen, MR Livesey, GJ Bassell, CN Svendsen, PC Kind, S Chandran, S Chattarji, DJA Wyllie
Mol Autism, 2020-06-19;11(1):52.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Remote nongenetic optical modulation of neuronal activity using fuzzy graphene
Authors: SK Rastogi, R Garg, MG Scopelliti, BI Pinto, JE Hartung, S Kim, CGE Murphey, N Johnson, D San Roman, F Bezanilla, JF Cahoon, MS Gold, M Chamanzar, T Cohen-Karn
Proc. Natl. Acad. Sci. U.S.A., 2020-06-01;0(0):.
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay

A Modular Differentiation System Maps Multiple Human Kidney Lineages from Pluripotent Stem Cells
Authors: H Tsujimoto, T Kasahara, SI Sueta, T Araoka, S Sakamoto, C Okada, SI Mae, T Nakajima, N Okamoto, D Taura, M Nasu, T Shimizu, M Ryosaka, Z Li, M Sone, M Ikeya, A Watanabe, K Osafune
Cell Rep, 2020-04-07;31(1):107476.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Extracellular nanovesicles for packaging of CRISPR-Cas9 protein and sgRNA to induce therapeutic exon skipping
Authors: P Gee, MSY Lung, Y Okuzaki, N Sasakawa, T Iguchi, Y Makita, H Hozumi, Y Miura, LF Yang, M Iwasaki, XH Wang, MA Waller, N Shirai, YO Abe, Y Fujita, K Watanabe, A Kagita, KA Iwabuchi, M Yasuda, H Xu, T Noda, J Komano, H Sakurai, N Inukai, A Hotta
Nat Commun, 2020-03-13;11(1):1334.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Pathogenic POGZ mutation causes impaired cortical development and reversible autism-like phenotypes
Authors: K Matsumura, K Seiriki, S Okada, M Nagase, S Ayabe, I Yamada, T Furuse, H Shibuya, Y Yasuda, H Yamamori, M Fujimoto, K Nagayasu, K Yamamoto, K Kitagawa, H Miura, N Gotoda-Nis, H Igarashi, M Hayashida, M Baba, M Kondo, S Hasebe, K Ueshima, A Kasai, Y Ago, A Hayata-Tak, N Shintani, T Iguchi, M Sato, S Yamaguchi, M Tamura, S Wakana, A Yoshiki, AM Watabe, H Okano, K Takuma, R Hashimoto, H Hashimoto, T Nakazawa
Nat Commun, 2020-02-26;11(1):859.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

In vitro testicular organogenesis from human fetal gonads produces fertilization-competent spermatids
Authors: Y Yuan, L Li, Q Cheng, F Diao, Q Zeng, X Yang, Y Wu, H Zhang, M Huang, J Chen, Q Zhou, Y Zhu, R Hua, J Tian, X Wang, Z Zhou, J Hao, J Yu, D Hua, J Liu, X Guo, Q Zhou, J Sha
Cell Res., 2020-02-21;0(0):.
Species: Human
Sample Types: Whole Tissue
Applications: Bioassay

Unveiling synapse pathology in spinal bulbar muscular atrophy by genome-wide transcriptome analysis of purified motor neurons derived from disease specific iPSCs
Authors: K Onodera, D Shimojo, Y Ishihara, M Yano, F Miya, H Banno, N Kuzumaki, T Ito, R Okada, B de Araújo, M Ohyama, M Yoshida, T Tsunoda, M Katsuno, M Doyu, G Sobue, H Okano, Y Okada
Mol Brain, 2020-02-19;13(1):18.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Viral Delivery of GDNF Promotes Functional Integration of Human Stem Cell Grafts in Parkinson's Disease
Authors: CW Gantner, IR de Luzy, JA Kauhausen, N Moriarty, JC Niclis, CR Bye, V Penna, CPJ Hunt, CM Ermine, CW Pouton, D Kirik, LH Thompson, CL Parish
Cell Stem Cell, 2020-02-13;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Alpha-synuclein fragments trigger distinct aggregation pathways
Authors: T Chakroun, V Evsyukov, NP Nykänen, M Höllerhage, A Schmidt, F Kamp, VC Ruf, W Wurst, TW Rösler, GU Höglinger
Cell Death Dis, 2020-02-03;11(2):84.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

FICD activity and AMPylation remodelling modulate human neurogenesis
Authors: P Kielkowski, IY Buchsbaum, VC Kirsch, NC Bach, M Drukker, S Cappello, SA Sieber
Nat Commun, 2020-01-24;11(1):517.
Species: Human
Sample Types: Whole Cells
Applications: Differentiation, Differentiation

Transcriptional Programming of Human Mechanosensory Neuron Subtypes from Pluripotent Stem Cells
Authors: AR Nickolls, MM Lee, DF Espinoza, M Szczot, RM Lam, Q Wang, J Beers, J Zou, MQ Nguyen, HJ Solinski, AA AlJanahi, KR Johnson, ME Ward, AT Chesler, CG Bönnemann
Cell Rep, 2020-01-21;30(3):932-946.e7.
Species: Human
Sample Types: Whole Cells
Applications: Differentiation, Differentiation

Peptides containing the MXXCW motif inhibit oncogenic RET kinase activity with a novel mechanism of action
Authors: K Takeda, Y Kawamoto, Y Nagasaki, Y Okuno, Y Goto, M Iida, I Yajima, N Ohgami, M Kato
Am J Cancer Res, 2020-01-01;10(1):336-349.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

GDNF and GFRalpha1 Are Required for Proper Integration of Adult-Born Hippocampal Neurons
Authors: A Bonafina, MF Trinchero, AS Ríos, P Bekinschte, AF Schinder, G Paratcha, F Ledda
Cell Rep, 2019-12-24;29(13):4308-4319.e4.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

Roles of Collagen XXV and Its Putative Receptors PTPsigma/delta in Intramuscular Motor Innervation and Congenital Cranial Dysinnervation Disorder
Authors: H Munezane, H Oizumi, T Wakabayash, S Nishio, T Hirasawa, T Sato, A Harada, T Yoshida, T Eguchi, Y Yamanashi, T Hashimoto, T Iwatsubo
Cell Rep, 2019-12-24;29(13):4362-4376.e6.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

Cellular alterations identified in pluripotent stem cell-derived midbrain spheroids generated from a female patient with progressive external ophthalmoplegia and parkinsonism who carries a novel variation (p.Q811R) in the POLG1 gene
Authors: M Chumarina, K Russ, C Azevedo, A Heuer, M Pihl, A Collin, EÅ Frostner, E Elmer, P Hyttel, G Cappellett, M Zini, S Goldwurm, L Roybon
Acta Neuropathol Commun, 2019-12-16;7(1):208.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Homogenous generation of dopaminergic neurons from multiple hiPSC lines by transient expression of transcription factors
Authors: S Mahajani, A Raina, C Fokken, S Kügler, M Bähr
Cell Death Dis, 2019-11-27;10(12):898.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

Functional characterization of human pluripotent stem cell-derived cortical networks differentiated on laminin-521 substrate: comparison to rat cortical cultures
Authors: T Hyvärinen, A Hyysalo, FE Kapucu, L Aarnos, A Vinogradov, SJ Eglen, L Ylä-Outine, S Narkilahti
Sci Rep, 2019-11-20;9(1):17125.
Species: Human
Sample Types: Whole Cells
Applications: Differentiation, Differentiation

Alpha7 nicotinic acetylcholine receptors and neural network synaptic transmission in human induced pluripotent stem cell-derived neurons
Authors: HM Larsen, SK Hansen, JD Mikkelsen, P Hyttel, TC Stummann
Stem Cell Res, 2019-10-31;41(0):101642.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

Immature mDA neurons ameliorate motor deficits in a 6-OHDA Parkinson's disease mouse model and are functional after cryopreservation
Authors: D Leitner, M Ramamoorth, M Dejosez, TP Zwaka
Stem Cell Res, 2019-10-24;41(0):101617.
Species: Human, Mouse
Sample Types: In Vitro, Whole Cells
Applications: Cell Culture, In vitro

Isolation of LMX1a ventral midbrain progenitors improves the safety and predictability of human pluripotent stem cell-derived neural transplants in Parkinsonian Disease
Authors: IR de Luzy, JC Niclis, CW Gantner, JA Kauhausen, CPJ Hunt, C Ermine, CW Pouton, LH Thompson, CL Parish
J. Neurosci., 2019-10-22;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

V2a interneuron differentiation from mouse and human pluripotent stem cells
Authors: JC Butts, N Iyer, N White, R Thompson, S Sakiyama-E, TC McDevitt
Nat Protoc, 2019-10-18;0(0):.
Species: Human, Mouse
Sample Types: Whole Cells
Applications: Bioassay

iPSC-derived functional human neuromuscular junctions model the pathophysiology of neuromuscular diseases
Authors: CY Lin, M Yoshida, LT Li, A Ikenaka, S Oshima, K Nakagawa, H Sakurai, E Matsui, T Nakahata, MK Saito
JCI Insight, 2019-09-19;4(18):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Mitigating Antagonism between Transcription and Proliferation Allows Near-Deterministic Cellular Reprogramming
Authors: KN Babos, KE Galloway, K Kisler, M Zitting, Y Li, Y Shi, B Quintino, RH Chow, BV Zlokovic, JK Ichida
Cell Stem Cell, 2019-09-12;25(4):486-500.e9.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

ATF4 destabilizes RET through nonclassical GRP78 inhibition to enhance chemosensitivity to bortezomib in human osteosarcoma
Authors: J Luo, Y Xia, Y Yin, J Luo, M Liu, H Zhang, C Zhang, Y Zhao, L Yang, L Kong
Theranostics, 2019-08-14;9(21):6334-6353.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Quantitative modelling predicts the impact of DNA methylation on RNA polymerase II traffic
Authors: J Cholewa-Wa, R Shah, S Webb, K Chhatbar, B Ramsahoye, O Pusch, M Yu, P Greulich, B Waclaw, AP Bird
Proc. Natl. Acad. Sci. U.S.A., 2019-07-09;116(30):14995-15000.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Generation of functional dopaminergic neurons from human spermatogonial stem cells to rescue parkinsonian phenotypes
Authors: H Yang, D Hao, C Liu, D Huang, B Chen, H Fan, C Liu, L Zhang, Q Zhang, J An, J Zhao
Stem Cell Res Ther, 2019-06-27;10(1):195.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

Microelectrode Array With Transparent ALD TiN Electrodes
Authors: T Ryynänen, A Pelkonen, K Grigoras, OME Ylivaara, T Hyvärinen, J Ahopelto, M Prunnila, S Narkilahti, J Lekkala
Front Neurosci, 2019-03-22;13(0):226.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Unbiased Profiling of Isogenic Huntington Disease hPSC-Derived CNS and Peripheral Cells Reveals Strong Cell-Type Specificity of CAG Length Effects
Authors: J Ooi, SR Langley, X Xu, KH Utami, B Sim, Y Huang, NP Harmston, YL Tay, A Ziaei, R Zeng, D Low, F Aminkeng, RM Sobota, F Ginhoux, E Petretto, MA Pouladi
Cell Rep, 2019-02-26;26(9):2494-2508.e7.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Translocator protein ligand protects against neurodegeneration in the MPTP mouse model of Parkinsonism
Authors: J Gong, ÉM Szeg?, A Leonov, E Benito, S Becker, A Fischer, M Zweckstett, T Outeiro, A Schneider
J. Neurosci., 2019-02-22;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Long Non-coding RNAs Associated With Neurodegeneration-Linked Genes Are Reduced in Parkinson's Disease Patients
Authors: M Elkouris, G Kouroupi, A Vourvoukel, N Papagianna, V Kaltezioti, R Matsas, L Stefanis, M Xilouri, PK Politis
Front Cell Neurosci, 2019-02-22;13(0):58.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Resveratrol alleviates chemotherapy-induced oogonial stem cell apoptosis and ovarian aging in mice
Authors: M Wu, L Ma, L Xue, W Ye, Z Lu, X Li, Y Jin, X Qin, D Chen, W Tang, Y Chen, Z Hong, J Zhang, A Luo, S Wang
Aging (Albany NY), 2019-02-14;11(3):1030-1044.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Reduced expression of somatostatin in GABAergic interneurons derived from induced pluripotent stem cells of patients with parkin mutations
Authors: C Iwasawa, N Kuzumaki, Y Suda, R Kagawa, Y Oka, N Hattori, H Okano, M Narita
Mol Brain, 2019-01-18;12(1):5.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

ALS-implicated protein TDP-43 sustains levels of STMN2, a mediator of motor neuron growth and repair
Authors: JR Klim, LA Williams, F Limone, I Guerra San, BN Davis-Duse, DA Mordes, A Burberry, MJ Steinbaugh, KK Gamage, R Kirchner, R Moccia, SH Cassel, K Chen, BJ Wainger, CJ Woolf, K Eggan
Nat. Neurosci., 2019-01-14;22(2):167-179.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Premature polyadenylation-mediated loss of stathmin-2 is a hallmark of TDP-43-dependent neurodegeneration
Authors: Z Melamed, J López-Erau, MW Baughn, O Zhang, K Drenner, Y Sun, F Freyermuth, MA McMahon, MS Beccari, JW Artates, T Ohkubo, M Rodriguez, N Lin, D Wu, CF Bennett, F Rigo, S Da Cruz, J Ravits, C Lagier-Tou, DW Cleveland
Nat. Neurosci., 2019-01-14;22(2):180-190.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Prevention of neuronal apoptosis by astrocytes through thiol-mediated stress response modulation and accelerated recovery from proteotoxic stress
Authors: S Gutbier, AS Spreng, J Delp, S Schildknec, C Karreman, I Suciu, T Brunner, M Groettrup, M Leist
Cell Death Differ., 2018-11-02;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Germline DNA replication timing shapes mammalian genome composition
Authors: Y Yehuda, B Blumenfeld, N Mayorek, K Makedonski, O Vardi, L Cohen-Dani, Y Mansour, S Baror-Sebb, H Masika, M Farago, M Berger, S Carmi, Y Buganim, A Koren, I Simon
Nucleic Acids Res., 2018-09-19;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Efficient derivation of sympathetic neurons from human pluripotent stem cells with a defined condition
Authors: K Kirino, T Nakahata, T Taguchi, MK Saito
Sci Rep, 2018-08-27;8(1):12865.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Modeling sporadic ALS in iPSC-derived motor neurons identifies a potential therapeutic agent
Authors: K Fujimori, M Ishikawa, A Otomo, N Atsuta, R Nakamura, T Akiyama, S Hadano, M Aoki, H Saya, G Sobue, H Okano
Nat. Med., 2018-08-20;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

The ubiquitin ligase UBR5 suppresses proteostasis collapse in pluripotent stem cells from Huntington's disease patients
Authors: S Koyuncu, I Saez, HJ Lee, R Gutierrez-, W Pokrzywa, A Fatima, T Hoppe, D Vilchez
Nat Commun, 2018-07-23;9(1):2886.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

A small-molecule inhibitor of SOD1-Derlin-1 interaction ameliorates pathology in an ALS mouse model
Authors: N Tsuburaya, K Homma, T Higuchi, A Balia, H Yamakoshi, N Shibata, S Nakamura, H Nakagawa, SI Ikeda, N Umezawa, N Kato, S Yokoshima, M Shibuya, M Shimonishi, H Kojima, T Okabe, T Nagano, I Naguro, K Imamura, H Inoue, T Fujisawa, H Ichijo
Nat Commun, 2018-07-10;9(1):2668.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Alpha6-Containing Nicotinic Acetylcholine Receptors Mediate Nicotine-Induced Structural Plasticity in Mouse and Human iPSC-Derived Dopaminergic Neurons
Authors: G Collo, L Cavalleri, M Zoli, U Maskos, E Ratti, E Merlo Pich
Front Pharmacol, 2018-06-01;9(0):572.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Combining NGN2 Programming with Developmental Patterning Generates Human Excitatory Neurons with NMDAR-Mediated Synaptic Transmission
Authors: R Nehme, E Zuccaro, SD Ghosh, C Li, JL Sherwood, O Pietilaine, LE Barrett, F Limone, KA Worringer, S Kommineni, Y Zang, D Cacchiarel, A Meissner, R Adolfsson, S Haggarty, J Madison, M Muller, P Arlotta, Z Fu, G Feng, K Eggan
Cell Rep, 2018-05-22;23(8):2509-2523.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Conserved and non-conserved characteristics of porcine glial cell line-derived neurotrophic factor expressed in the testis
Authors: K Kakiuchi, K Taniguchi, H Kubota
Sci Rep, 2018-05-16;8(1):7656.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Dissecting the Functional Consequences of De Novo DNA Methylation Dynamics in Human Motor Neuron Differentiation and Physiology
Authors: MJ Ziller, JA Ortega, KA Quinlan, DP Santos, H Gu, EJ Martin, C Galonska, R Pop, S Maidl, A Di Pardo, M Huang, HY Meltzer, A Gnirke, CJ Heckman, A Meissner, E Kiskinis
Cell Stem Cell, 2018-03-15;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

In vitro differentiation of human oocyte-like cells from oogonial stem cells: single-cell isolation and molecular characterization
Authors: E Silvestris, P Cafforio, S D'Oronzo, C Felici, F Silvestris, G Loverro
Hum. Reprod., 2018-03-01;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Ropinirole and Pramipexole Promote Structural Plasticity in Human iPSC-Derived Dopaminergic Neurons via BDNF and mTOR Signaling
Authors: G Collo, L Cavalleri, F Bono, C Mora, S Fedele, RW Invernizzi, M Gennarelli, G Piovani, T Kunath, MJ Millan, E Merlo Pich, P Spano
Neural Plast., 2018-02-04;2018(0):4196961.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Streamlined circular proximity ligation assay provides high stringency and compatibility with low-affinity antibodies
Authors: R Jalili, J Horecka, JR Swartz, RW Davis, HHJ Persson
Proc. Natl. Acad. Sci. U.S.A., 2018-01-16;0(0):.
Applications: Bioassay

Alternative NHEJ pathway proteins as components of MYCN oncogenic activity in human neural crest stem cell differentiation: implications for neuroblastoma initiation
Authors: EA Newman, S Chukkapall, D Bashllari, TT Thomas, RA Van Noord, ER Lawlor, MJ Hoenerhoff, AW Opipari, VP Opipari
Cell Death Dis, 2017-12-13;8(12):3208.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Altered Differentiation Potential of Gaucher's Disease iPSC Neuronal Progenitors due to Wnt/?-Catenin Downregulation
Authors: O Awad, LM Panicker, RM Deranieh, MP Srikanth, RA Brown, A Voit, T Peesay, TS Park, ET Zambidis, RA Feldman
Stem Cell Reports, 2017-11-30;9(6):1853-1867.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Directly Converted Human Fibroblasts Mature to Neurons and Show Long-Term Survival in Adult Rodent Hippocampus
Authors: N Avaliani, U Pfisterer, A Heuer, M Parmar, M Kokaia, M Andersson
Stem Cells Int, 2017-11-26;2017(0):5718608.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Constitutively Active SMAD2/3 Are Broad-Scope Potentiators of Transcription-Factor-Mediated Cellular Reprogramming
Authors: T Ruetz, U Pfisterer, B Di Stefano, J Ashmore, M Beniazza, TV Tian, DF Kaemena, L Tosti, W Tan, JR Manning, E Chantzoura, DR Ottosson, S Collombet, A Johnsson, E Cohen, K Yusa, S Linnarsson, T Graf, M Parmar, K Kaji
Cell Stem Cell, 2017-11-22;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Higher-Order Kidney Organogenesis from Pluripotent Stem Cells
Authors: A Taguchi, R Nishinakam
Cell Stem Cell, 2017-11-09;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

The protein phosphatase 1 regulator NIPP1 is essential for mammalian spermatogenesis
Authors: M Ferreira, S Boens, C Winkler, K Szekér, I Verbinnen, A Van Eynde, M Fardilha, M Bollen
Sci Rep, 2017-10-17;7(1):13364.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Protective efficacy of phosphodiesterase-1 inhibition against alpha-synuclein toxicity revealed by compound screening in LUHMES cells
Authors: M Höllerhage, C Moebius, J Melms, WH Chiu, JN Goebel, T Chakroun, T Koeglsperg, WH Oertel, TW Rösler, M Bickle, GU Höglinger
Sci Rep, 2017-09-13;7(1):11469.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Isolation and characterization of string-forming female germline stem cells from ovaries of neonatal mice
Authors: J Liu, D Shang, Y Xiao, P Zhong, H Cheng, R Zhou
J. Biol. Chem., 2017-08-21;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Acellular Mouse Kidney ECM can be Used as a Three-Dimensional Substrate to Test the Differentiation Potential of Embryonic Stem Cell Derived Renal Progenitors
Authors: M Sambi, T Chow, J Whiteley, M Li, S Chua, V Raileanu, IM Rogers
Stem Cell Rev, 2017-08-01;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

REST suppression mediates neural conversion of adult human fibroblasts via microRNA-dependent and -independent pathways
Authors: J Drouin-Oue, S Lau, PL Brattås, D Rylander O, K Pircs, DA Grassi, LM Collins, R Vuono, A Andersson, G Westergren, C Graff, L Minthon, H Toresson, RA Barker, J Jakobsson, M Parmar
EMBO Mol Med, 2017-08-01;9(8):1117-1131.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

RET-mediated glial cell line derived neurotrophic factor signaling inhibits mouse prostate development
Authors: HJ Park, EC Bolton
Development, 2017-05-15;0(0):.
Species: Mouse
Sample Types: Whole Tissue
Applications: Bioassay

Optimal culture conditions are critical for efficient expansion of human testicular somatic and germ cells in�vitro
Authors: I Gat, L Maghen, M Filice, B Wyse, K Zohni, K Jarvi, KC Lo, A Gauthier F, C Librach
Fertil. Steril, 2017-03-01;107(3):595-605.e7.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Molecular analyses of neurogenic defects in a human pluripotent stem cell model of fragile X syndrome
Authors: MJ Boland, KL Nazor, HT Tran, A Szücs, CL Lynch, R Paredes, F Tassone, PP Sanna, RJ Hagerman, JF Loring
Brain, 2017-03-01;140(3):582-598.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

DDX4-EGFP transgenic rat model for the study of germline development and spermatogenesis
Authors: K Gassei, Y Sheng, A Fayomi, P Mital, M Sukhwani, CC Lin, KA Peters, A Althouse, H Valli, KE Orwig
Biol. Reprod., 2017-03-01;96(3):707-719.
Species: Rat
Sample Types: Whole Cells
Applications: Cell Culture

Alpha-synuclein prevents the formation of spherical mitochondria and apoptosis under oxidative stress
Authors: S Menges, G Minakaki, PM Schaefer, H Meixner, I Prots, U Schlötzer-, K Friedland, B Winner, TF Outeiro, KF Winklhofer, CA von Arnim, W Xiang, J Winkler, J Klucken
Sci Rep, 2017-02-22;7(0):42942.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Rapid differentiation of human pluripotent stem cells into functional neurons by mRNAs encoding transcription factors
Authors: SK Goparaju, K Kohda, K Ibata, A Soma, Y Nakatake, T Akiyama, S Wakabayash, M Matsushita, M Sakota, H Kimura, M Yuzaki, SB Ko, MS Ko
Sci Rep, 2017-02-13;7(0):42367.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Neurotoxic reactive astrocytes are induced by activated microglia
Authors: SA Liddelow, KA Guttenplan, LE Clarke, FC Bennett, CJ Bohlen, L Schirmer, ML Bennett, AE Mnch, WS Chung, TC Peterson, DK Wilton, A Frouin, BA Napier, N Panicker, M Kumar, MS Buckwalter, DH Rowitch, VL Dawson, TM Dawson, B Stevens, BA Barres
Nature, 2017-01-18;541(7638):481-487.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Increased susceptibility to a? toxicity in neuronal cultures derived from familial Azheimer's disease (PSEN1-A246E) induced pluripotent stem cells
Authors: Enrique Armijo
Neurosci. Lett, 2016-12-26;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Histones facilitate ?-synuclein aggregation during neuronal apoptosis
Authors: Peizhou Jiang
Acta Neuropathol, 2016-12-21;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Effects of Feeder Cells on Dopaminergic Differentiation of Human Embryonic Stem Cells
Authors: Z Zhao, Y Ma, Z Chen, Q Liu, Q Li, D Kong, K Yuan, L Hu, T Wang, X Chen, Y Peng, W Jiang, Y Yu, X Liu
Front Cell Neurosci, 2016-12-20;10(0):291.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Small molecules increase direct neural conversion of human fibroblasts
Sci Rep, 2016-12-05;6(0):38290.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Sustained synchronized neuronal network activity in a human astrocyte co-culture system
Sci Rep, 2016-11-07;6(0):36529.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Analysis of induced pluripotent stem cells carrying 22q11.2 deletion.
Authors: T Yoshikawa, Hisano Y, Iwayama Y, Toyota T, Itasaka N, Dean B
Transl Psychiatry, 2016-11-01;6(11):e934.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

A robust vitronectin-derived peptide for the scalable long-term expansion and neuronal differentiation of human pluripotent stem cell (hPSC)-derived neural progenitor cells (hNPCs)
Authors: Divya Varun
Acta Biomater, 2016-10-27;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Efficiently Specified Ventral Midbrain Dopamine Neurons from Human Pluripotent Stem Cells Under Xeno-Free Conditions Restore Motor Deficits in Parkinsonian Rodents
Authors: JC Niclis, CW Gantner, WF Alsanie, SJ McDougall, CR Bye, AG Elefanty, EG Stanley, JM Haynes, CW Pouton, LH Thompson, CL Parish
Stem Cells Transl Med, 2016-10-14;6(3):937-948.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

MicroRNA-302 switch to identify and eliminate undifferentiated human pluripotent stem cells
Sci Rep, 2016-09-09;6(0):32532.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Microglial AGE-albumin is critical for neuronal death in Parkinson's disease: a possible implication for theranostics
Int J Nanomedicine, 2016-08-23;10(0):281-92.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Microfabric Vessels for Embryoid Body Formation and Rapid Differentiation of Pluripotent Stem Cells
Sci Rep, 2016-08-10;6(0):31063.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

A deleterious Nav1.1 mutation selectively impairs telencephalic inhibitory neurons derived from Dravet Syndrome patients
Elife, 2016-07-26;5(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Gene Expression Differences in Peripheral Blood of Parkinson's Disease Patients with Distinct Progression Profiles
Authors: Raquel Pinho
PLoS ONE, 2016-06-20;11(6):e0157852.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Isolation, expansion and neural differentiation of stem cells from human plucked hair: a further step towards autologous nerve recovery
Authors: Margriet A Huisman
Cytotechnology, 2015-12-24;68(5):1849-58.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Assessment of TTX-s and TTX-r Action Potential Conduction along Neurites of NGF and GDNF Cultured Porcine DRG Somata.
Authors: Jonas R, Klusch A, Schmelz M, Petersen M, Carr R
PLoS ONE, 2015-09-25;10(9):e0139107.
Species: Porcine
Sample Types: Whole Cells
Applications: Bioassay

Noggin Over-Expressing Mouse Embryonic Fibroblasts and MS5 Stromal Cells Enhance Directed Differentiation of Dopaminergic Neurons from Human Embryonic Stem Cells.
Authors: Lim M, Shin M, Lee S, Minn Y, Hoh J, Cho Y, Kim D, Lee S, Kim C, Park C
PLoS ONE, 2015-09-18;10(9):e0138460.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Dopaminergic control of autophagic-lysosomal function implicates Lmx1b in Parkinson's disease.
Authors: Laguna A, Schintu N, Nobre A, Alvarsson A, Volakakis N, Jacobsen J, Gomez-Galan M, Sopova E, Joodmardi E, Yoshitake T, Deng Q, Kehr J, Ericson J, Svenningsson P, Shupliakov O, Perlmann T
Nat Neurosci, 2015-04-27;18(6):826-35.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Generation of neuropeptidergic hypothalamic neurons from human pluripotent stem cells.
Authors: Merkle F, Maroof A, Wataya T, Sasai Y, Studer L, Eggan K, Schier A
Development, 2015-02-15;142(4):633-43.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

The sirtuin-2 inhibitor AK7 is neuroprotective in models of Parkinson's disease but not amyotrophic lateral sclerosis and cerebral ischemia.
Authors: Chen X, Wales P, Quinti L, Zuo F, Moniot S, Herisson F, Rauf N, Wang H, Silverman R, Ayata C, Maxwell M, Steegborn C, Schwarzschild M, Outeiro T, Kazantsev A
PLoS ONE, 2015-01-21;10(1):e0116919.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Human iPSC-derived motoneurons harbouring TARDBP or C9ORF72 ALS mutations are dysfunctional despite maintaining viability.
Authors: Devlin, Anna-Cla, Burr, Karen, Borooah, Shyamang, Foster, Joshua D, Cleary, Elaine M, Geti, Imbisaat, Vallier, Ludovic, Shaw, Christop, Chandran, Siddhart, Miles, Gareth B
Nat Commun, 2015-01-12;6(0):5999.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Histone hyperacetylation up-regulates protein kinase Cdelta in dopaminergic neurons to induce cell death: relevance to epigenetic mechanisms of neurodegeneration in Parkinson disease.
Authors: Jin H, Kanthasamy A, Harischandra D, Kondru N, Ghosh A, Panicker N, Anantharam V, Rana A, Kanthasamy A
J Biol Chem, 2014-10-23;289(50):34743-67.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Highly efficient generation of induced neurons from human fibroblasts that survive transplantation into the adult rat brain.
Authors: Pereira, Maria, Pfisterer, Ulrich, Rylander, Daniella, Torper, Olof, Lau, Shong, Lundblad, Martin, Grealish, Shane, Parmar, Malin
Sci Rep, 2014-09-11;4(0):6330.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Lineage-specific regulation of epigenetic modifier genes in human liver and brain.
Authors: Weng, Matthias, Natarajan, Karthick, Scholz, Diana, Ivanova, Violeta, Sachinidis, Agapios, Hengstler, Jan G, Waldmann, Tanja, Leist, Marcel
PLoS ONE, 2014-07-23;9(7):e102035.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Widespread sequence variations in VAMP1 across vertebrates suggest a potential selective pressure from botulinum neurotoxins.
Authors: Peng, Lisheng, Adler, Michael, Demogines, Ann, Borrell, Andrew, Liu, Huisheng, Tao, Liang, Tepp, William, Zhang, Su-Chun, Johnson, Eric A, Sawyer, Sara L, Dong, Min
PLoS Pathog, 2014-07-10;10(7):e1004177.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

The phosphorylation status of Ascl1 is a key determinant of neuronal differentiation and maturation in vivo and in vitro.
Authors: Ali F, Cheng K, Kirwan P, Metcalfe S, Livesey F, Barker R, Philpott A
Development, 2014-05-12;141(11):2216-24.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

iPSC-derived forebrain neurons from FXS individuals show defects in initial neurite outgrowth.
Authors: Doers, Matthew, Musser, Michael, Nichol, Robert, Berndt, Erich R, Baker, Mei, Gomez, Timothy, Zhang, Su-Chun, Abbeduto, Leonard, Bhattacharyya, Anita
Stem Cells Dev, 2014-04-30;23(15):1777-87.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Characterization of the stability and bio-functionality of tethered proteins on bioengineered scaffolds: implications for stem cell biology and tissue repair.
Authors: Wang T, Bruggeman K, Sheean R, Turner B, Nisbet D, Parish C
J Biol Chem, 2014-04-03;289(21):15044-51.
Species: N/A, Synthetic
Sample Types: Complex Sample Type
Applications: Bioassay

Direct conversion of human fibroblasts into neuronal restricted progenitors.
Authors: Zou, Qingjian, Yan, Quanmei, Zhong, Juan, Wang, Kepin, Sun, Haitao, Yi, Xiaoling, Lai, Liangxue
J Biol Chem, 2014-01-02;289(8):5250-60.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

MEK/ERK signaling directly and indirectly contributes to the cyclical self-renewal of spermatogonial stem cells.
Authors: Hasegawa K, Namekawa S, Saga Y
Stem Cells, 2013-11-01;31(11):2517-27.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

Functional neuroprotection and efficient regulation of GDNF using destabilizing domains in a rodent model of Parkinson's disease.
Authors: Quintino L, Manfre G, Wettergren E, Namislo A, Isaksson C, Lundberg C
Mol Ther, 2013-07-24;21(12):2169-80.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

alpha-Synuclein oligomers impair neuronal microtubule-kinesin interplay.
Authors: Prots I, Veber V, Brey S, Campioni S, Buder K, Riek R, Bohm K, Winner B
J Biol Chem, 2013-06-06;288(30):21742-54.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

A human Dravet syndrome model from patient induced pluripotent stem cells.
Authors: Higurashi N, Uchida T, Lossin C, Misumi Y, Okada Y, Akamatsu W, Imaizumi Y, Zhang B, Nabeshima K, Mori M, Katsurabayashi S, Shirasaka Y, Okano H, Hirose S
Mol Brain, 2013-05-02;6(0):19.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Isolation, characterization and propagation of mitotically active germ cells from adult mouse and human ovaries.
Authors: Woods D, Tilly J
Nat Protoc, 2013-04-18;8(5):966-88.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

A small molecule screen in stem-cell-derived motor neurons identifies a kinase inhibitor as a candidate therapeutic for ALS.
Authors: Yang Y, Gupta S, Kim K, Powers B, Cerqueira A, Wainger B, Ngo H, Rosowski K, Schein P, Ackeifi C, Arvanites A, Davidow L, Woolf C, Rubin L
Cell Stem Cell, 2013-04-18;12(6):713-26.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

MicroRNA-based promotion of human neuronal differentiation and subtype specification.
Authors: Stappert L, Borghese L, Roese-Koerner B, Weinhold S, Koch P, Terstegge S, Uhrberg M, Wernet P, Brustle O
PLoS ONE, 2013-03-18;8(3):e59011.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

RET is a potential tumor suppressor gene in colorectal cancer.
Authors: Luo, Y, Tsuchiya, K D, Il Park, D, Fausel, R, Kanngurn, S, Welcsh, P, Dzieciatkowski, S, Wang, J, Grady, W M
Oncogene, 2012-07-02;32(16):2037-47.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

RET PLC-gamma phosphotyrosine binding domain regulates Ca2+ signaling and neocortical neuronal migration.
Authors: Lundgren TK, Nakahata K, Fritz N, Rebellato P, Zhang S, Uhlen P
PLoS ONE, 2012-02-15;7(2):e31258.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Soluble Endoglin Specifically Binds Bone Morphogenetic Proteins 9 and 10 via Its Orphan Domain, Inhibits Blood Vessel Formation, and Suppresses Tumor Growth.
Authors: Castonguay R, Werner ED, Matthews RG, Presman E, Mulivor AW, Solban N, Sako D, Pearsall RS, Underwood KW, Seehra J, Kumar R, Grinberg AV
J. Biol. Chem., 2011-07-07;286(34):30034-46.
Species: Human, Mouse
Sample Types: Recombinant Protein
Applications: Surface Plasmon Resonance

Glial cell line-derived neurotrophic factor and endothelial cells promote self-renewal of rabbit germ cells with spermatogonial stem cell properties.
Authors: Kubota H, Wu X, Goodyear SM, Avarbock MR, Brinster RL
FASEB J., 2011-04-27;25(0):2604-14.
Species: Rabbit
Sample Types: Whole Cells
Applications: Bioassay

Pharmacokinetics and bioactivity of glial cell line-derived factor (GDNF) and neurturin (NTN) infused into the rat brain.
Authors: Hadaczek P, Johnston L, Forsayeth J, Bankiewicz KS
Neuropharmacology, 2010-02-11;58(7):1114-21.
Species: Rat
Sample Types: In Vivo
Applications: In Vivo

Sustained intraspinal delivery of neurotrophic factor encapsulated in biodegradable nanoparticles following contusive spinal cord injury.
Authors: Wang YC, Wu YT, Huang HY, Lin HI, Lo LW, Tzeng SF, Yang CS
Biomaterials, 2008-09-06;29(34):4546-53.
Species: Rat
Sample Types: In Vivo
Applications: In Vivo

A novel immunoprecipitation strategy identifies a unique functional mimic of the glial cell line-derived neurotrophic factor family ligands in the pathogen Trypanosoma cruzi.
Authors: Lu B, PereiraPerrin M
Infect. Immun., 2008-06-09;76(8):3530-8.
Species: Bacteria
Sample Types: Trypanosoma
Applications: ELISA (Capture)

Lineage selection of functional and cryopreservable human embryonic stem cell-derived neurons.
Authors: Ladewig J, Koch P, Endl E, Meiners B, Opitz T, Couillard-Despres S, Aigner L, Brustle O
Stem Cells, 2008-04-17;26(7):1705-12.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

SULF1 and SULF2 regulate heparan sulfate-mediated GDNF signaling for esophageal innervation.
Authors: Ai X, Kitazawa T, Do AT, Kusche-Gullberg M, Labosky PA, Emerson CP
Development, 2007-09-01;134(18):3327-38.
Species: Mouse
Sample Types: Beads, Whole Tissue
Applications: Bioassay

Directed neural differentiation of human embryonic stem cells via an obligated primitive anterior stage.
Authors: Pankratz MT, Li XJ, Lavaute TM, Lyons EA, Chen X, Zhang SC
Stem Cells, 2007-03-01;25(6):1511-20.
Species: Human, Primate - Macaca mulatta (Rhesus Macaque)
Sample Types: Whole Cells
Applications: Bioassay

Multipotent adult progenitor cells from swine bone marrow.
Authors: Zeng L, Rahrmann E, Hu Q, Lund T, Sandquist L, Felten M, O'Brien TD, O'Brien TD, Zhang J, Verfaillie C
Stem Cells, 2006-08-24;24(11):2355-66.
Species: Porcine
Sample Types: Whole Cells
Applications: Bioassay

Endothelin-3 regulates neural crest cell proliferation and differentiation in the hindgut enteric nervous system.
Authors: Nagy N, Goldstein AM
Dev. Biol., 2006-03-06;293(1):203-17.
Species: Chicken
Sample Types: Whole Tissue
Applications: Bioassay

Trophic factor modulation of cocaine- and amphetamine-regulated transcript peptide expression in explant cultured guinea-pig cardiac neurons.
Authors: Girard BM, Young BA, Buttolph TR, Locknar SA, White SL, Parsons RL
Neuroscience, 2006-03-03;139(4):1329-41.
Species: Guinea Pig
Sample Types: Whole Cells
Applications: Bioassay

Ventral midbrain glia express region-specific transcription factors and regulate dopaminergic neurogenesis through Wnt-5a secretion.
Authors: Castelo-Branco G, Sousa KM, Bryja V, Pinto L, Wagner J, Arenas E
Mol. Cell. Neurosci., 2005-10-21;31(2):251-62.
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay

Derivation of midbrain dopamine neurons from human embryonic stem cells.
Authors: Perrier AL, Tabar V, Barberi T, Rubio ME, Bruses J, Topf N, Harrison NL, Studer L
Proc. Natl. Acad. Sci. U.S.A., 2004-08-13;101(34):12543-8.
Species: Human, Primate - Macaca mulatta (Rhesus Macaque)
Sample Types: Whole Cells
Applications: Bioassay

Rapid axoglial signaling mediated by neuregulin and neurotrophic factors.
Authors: Esper RM, Loeb JA
J. Neurosci., 2004-07-07;24(27):6218-27.
Species: Chicken
Sample Types: Whole Cells
Applications: Bioassay