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PPDA

Catalog #: 2530
5 Citations Datasheet / COA / SDS
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2530/50
PPDA | CAS No. 684283-16-7 | NMDA Receptor Antagonists
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Description: GluN2C/GluN2D-selective NMDA antagonist

Chemical Name: (2S*,3R*)-1-(Phenanthren-2-carbonyl)piperazine-2,3-dicarboxylic acid

Purity: ≥98%

Product Details
Citations (5)
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

PPDA is a subtype-selective NMDA receptor antagonist that preferentially binds to GluN2C/GluN2D (formally NR2C/NR2D) containing receptors (Ki values are 0.096, 0.125, 0.31 and 0.55 μM for GluN2C, GluN2D, GluN2B and GluN2A subunits respectively).

Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.

Technical Data

M.Wt:
378.38
Formula:
C21H18N2O5
Solubility:
Soluble to 50 mM in 2eq. NaOH and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
684283-16-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from UNeMed Corporation.

Product Datasheets

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Citations for PPDA

The citations listed below are publications that use Tocris products. Selected citations for PPDA include:

5 Citations: Showing 1 - 5

  1. Neuronal firing patterns outweigh circuitry oscillations in parkinsonian motor control.
    Authors: Pan Et al.
    J Clin Invest  2016;126:4516
  2. Distinct molecular components for thalamic- and cortical-dependent plasticity in the lateral amygdala.
    Authors: Mirante Et al.
    Autophagy  2014;7:62
  3. Altered gamma oscillations during pregnancy through loss of δ subunit-containing GABA(A) receptors on parvalbumin interneurons.
    Authors: Ferando and Mody
    Front Neural Circuits  2013;7:144
  4. Pharmacological evidence that D-aspartate activates a current distinct from ionotropic glutamate receptor currents in Aplysia californica.
    Authors: Carlson Et al.
    Brain Behav  2012;2:391
  5. Unique ionotropic receptors for D-aspartate are a target for serotonin-induced synaptic plasticity in Aplysia californica.
    Authors: Carlson and Fieber
    Comp Biochem Physiol C Toxicol Pharmacol  2012;155:151

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