PF 06273340
Chemical Name: N-[5-[[2-Amino-7-(2-hydroxy-1,1-dimethylethyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]carbonyl]-3-pyridinyl]-5-chloro-2-pyridineacetamide
Purity: ≥98%
Biological Activity
PF 06273340 is a potent and selective pan-Trk inhibitor (IC50 values are 1, 2 and 6 nM for Trk C, B and A, respectively). Selective for Trk over a panel of ion channels, receptors and other enzymes. Peripherally restricted. Exhibits efficacy in a rodent model of inflammatory pain. Orally bioavailable.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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The discovery of a potent, selective, and peripherally restricted pan-Trk inhibitor (PF-06273340) for the treatment of pain.
Skerratt et al.
J.Med.Chem., 2016;59:10084
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Citation for PF 06273340
The citations listed below are publications that use Tocris products. Selected citations for PF 06273340 include:
1 Citation: Showing 1 - 1
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Combined c-Met/Trk Inhibition Overcomes Resistance to CDK4/6 Inhibitors in Glioblastoma.
Authors: Jeongwu Et al.
Cancer Res 2018;78:4360-4369
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Measured cancer cell viability upon treatment with this drug at various concentrations including 5 and 10 uM. In addition, compared it to a specific siRNA.
