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Mouse Lymphotoxin  beta R/TNFRSF3 Biotinylated Antibody

Catalog #: BAF1008
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BAF1008
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Citations (1)
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Mouse Lymphotoxin  beta R/TNFRSF3 Biotinylated Antibody Summary

Species Reactivity
Mouse
Specificity
Detects Lymphotoxin beta R/TNFRSF3 in Western blots. In Western blots, approximately 10% cross-reactivity with recombinant human (rh) LT beta  R is observed and less than 1% cross-reactivity with recombinant mouse (rm) 4-1BB, rmCD27, rmCD30, rmCD40, rmEDAR, rmFas, rmGITR, rmOPG, rmRANK, rmTNF RI, and rmTNF RII is observed.
Source
Polyclonal Goat IgG
Purification
Antigen Affinity-purified
Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse Lymphotoxin beta R/TNFRSF3
Ser28-Pro218
Accession # P50284
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
Label
Biotin

Applications

Recommended Concentration
Sample
Western Blot
0.1 µg/mL
Recombinant Mouse Lymphotoxin  beta R/TNFRSF3
Flow Cytometry
0.25 µg/106 cells
Mouse whole blood
Immunohistochemistry
5-15 µg/mL
Perfusion fixed frozen sections of mouse thymus

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Reconstitute at 0.2 mg/mL in sterile PBS.
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Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Lymphotoxin beta R/TNFRSF3

Lymphotoxin beta receptor (LTbR), also known as TNFRSF3, TNF RIII, and TNF Rrp, is a transmembrane receptor for the homotrimeric LIGHT/TNFSF14 and the heterotrimeric LTalpha1/beta2. LTbR engagement induces production of IL-7, RANK, TRANCE/RANK L, VEGF-C, the adhesion molecules VCAM-1, ICAM-1, and MAdCAM, and the chemokines CXCL13, CCL19 and CCL21. LTbR is expressed on mesenchymal stromal organizing cells that give rise to stroma of primary (thymus), secondary (tonsils, lymph nodes, and Peyers patches) and tertiary (ectopic inflammatory) lymphoid structures. It is expressed by hepatocytes and is upregulated in regeneration, hepatitis, and hepatocellular carcinoma where it regulates lipid metabolismd. A soluble form of LTbR can be released and functions an inhibitor of transmembrane LTbR.

Long Name
Lymphotoxin beta Receptor
Entrez Gene IDs
4055 (Human); 17000 (Mouse); 297604 (Rat); 102135920 (Cynomolgus Monkey); 712550 (Rhesus Macaque)
Alternate Names
CD18; D12S370; ltbetar; LT-BETA-R; LTBR; lymphotoxin B receptor; Lymphotoxin beta R; lymphotoxin beta receptor (TNFR superfamily, member 3); Lymphotoxin-beta receptor; LymphotoxinbR; TNF RIII; TNF Rrp; TNFCRTNF-RIII; TNFR superfamily, member 3; TNFR2-RP; TNFR3; TNF-R-III; TNFR-RP; TNFRSF3; TNFRSF3TNFR-III; Tumor necrosis factor C receptor; Tumor necrosis factor receptor 2-related protein; tumor necrosis factor receptor superfamily member 3; tumor necrosis factor receptor superfamily, member 3; Tumor necrosis factor receptor type III

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Citation for Mouse Lymphotoxin  beta R/TNFRSF3 Biotinylated Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

1 Citation: Showing 1 - 1

  1. Cooperative function of CCR7 and lymphotoxin in the formation of a lymphoma-permissive niche within murine secondary lymphoid organs.
    Authors: Rehm A, Mensen A, Schradi K, Gerlach K, Wittstock S, Winter S, Buchner G, Dorken B, Lipp M, Hopken UE
    Blood, 2011-05-17;118(4):1020-33.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Flow Cytometry

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