Mouse CXCR7/RDC-1 Antibody Summary
Met1-Leu47, Ser103-Lys118, Lys184-Glu213, Leu274-Ala296
Accession # P56485
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Detection of CXCR7 in D3 Mouse Cell Line by Flow Cytometry. D3 mouse embryonic stem cell line was stained with Rat Anti-Mouse CXCR7/RDC‑1 Monoclonal Antibody (Catalog # MAB7167, filled histo-gram) or isotype control antibody rat IgM (open histogram), followed by Allophycocyanin-conjugated Anti-Rat IgM Secondary Antibody.
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Detection of CXCR7 in HEK293 Human Cell Line Transfected with eGFP and Mouse CXCR7/RDC-1 by Flow Cytometry. HEK293 human embryonic kidney cell line transfected with eGFP and Mouse CXCR7/RDC-1 were stained with Rat Anti-Mouse CXCR7/RDC‑1 Monoclonal Antibody (Catalog # MAB7167) followed by Allophycocyanin-conjugated-Anti-Rat IgM secondary antibody. Quadrant markers were set based on control antibody staining.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: CXCR7/RDC-1
CXCR7 (CXC chemokine receptor 7; also GPRN1, RDC-1 and chemokine orphan receptor 1) is a 60 kDa member of the G-protein coupled receptor 1 family. It is expressed on multiple cell types, including neurons, T cells, NK cells, neutrophils, B cells plus angiogenic endothelial cells. CXCR7 forms both homodimers and heterodimers with CXCR4. It selectively binds I-TAC and SDF1, and appears to involve beta -arrestin2 during signaling. Notably, a CXCR7:CXCR4 heterodimer shows increased responsiveness to SDF1, and I-TAC may actually block some SDF1-mediated migration activity. Mouse CXCR7 is a 7-transmembrane glycoprotein that is 362 amino acids (aa) in length. It contains a 47 aa N-terminal extracellular region plus a 43 aa C-terminal cytoplasmic domain. Over the collective extracellular domains (aa 1-47, 103-118, 184-213 and 274-296), mouse CXCR7 shares 97% and 91% aa identity with rat and human CXCR7, respectively.
Product Datasheets
Citations for Mouse CXCR7/RDC-1 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 2
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CXCR7 Mediates Neural Progenitor Cells Migration to CXCL12 Independent of CXCR4.
Authors: Chen Q, Zhang M, Li Y, Xu D, Wang Y, Song A, Zhu B, Huang Y, Zheng J
Stem Cells, 2015-05-13;33(8):2574-85.
Species: Mouse
Sample Types: Whole Cells
Applications: IHC -
MicroRNA-126/stromal cell-derived factor 1/C-X-C chemokine receptor type 7 signaling pathway promotes post-stroke angiogenesis of endothelial progenitor cell transplantation
Authors: C Shan, Y Ma
Mol Med Rep, 2018-01-29;0(0):.
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