Mouse CD11c Alexa Fluor® 488-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: CD11c

The Integrin alpha X subunit, also known as CD11c, is a 150 kDa type I transmembrane protein that noncovalently heterodimerizes with the beta 2 subunit (CD18) to form alpha X/ beta 2, also known as p150/p95 and complement receptor type 4 (CR4). Integrin alpha X beta 2 is expressed on macrophages, dendritic cells, CD8⁺ T cells, and other leukocyte subsets. The 1097 aa mouse alpha X extracellular domain shares 71% and 87% amino acid (aa) identity with human and rat alpha X, respectively. One potential alpha X isoform is truncated at aa 828. Some adhesion partners of alpha X beta 2 are shared with alpha M beta 2/CD11b:CD18 (complement iC3b, ICAMs, vWF and fibrinogen) while other adhesion partners (osteopontin, Thy-1, plasminogen, heparin) are unique. Unlike alpha M beta 2,  alpha X beta 2 is not constitutively active. alpha X beta 2 adhesion mediates cell proliferation, degranulation, chemotactic migration, and phagocytosis of complement-opsonized particles.

Product Datasheets

Product Specific Notices

This product is provided under an agreement between Life Technologies Corporation and R&D Systems, Inc, and the manufacture, use, sale or import of this product is subject to one or more US patents and corresponding non-US equivalents, owned by Life Technologies Corporation and its affiliates. The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components (1) in manufacturing; (2) to provide a service, information, or data to an unaffiliated third party for payment; (3) for therapeutic, diagnostic or prophylactic purposes; (4) to resell, sell, or otherwise transfer this product or its components to any third party, or for any other commercial purpose. Life Technologies Corporation will not assert a claim against the buyer of the infringement of the above patents based on the manufacture, use or sale of a commercial product developed in research by the buyer in which this product or its components was employed, provided that neither this product nor any of its components was used in the manufacture of such product. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, Cell Analysis Business Unit, Business Development, 29851 Willow Creek Road, Eugene, OR 97402, Tel: (541) 465-8300. Fax: (541) 335-0354.

Related Research Areas

• Adhesion Molecules
• Adhesion Molecules in Angiogenesis
• Adhesive Interactions in Allergy and Asthma
• B Cell Chemotaxis, Migration, and Adhesion
• Basophils
• Common Macrophage Markers
• Conventional/Classical Dendritic Cells
• Granulocyte Markers
• Inflammatory/Monocyte-derived Dendritic Cells
• Integrins and Associated Molecules
• Isolation, Culture, and Identification of Natural Killer Cells
• Langerhans and Dermal Dendritic Cells
• MDSC Phenotyping - Negative Markers
• Monocyte Markers
• Mouse Tissue-Resident Macrophage Markers
• Plasmacytoid Dendritic Cells
• T Cell Migration/Adhesion