Home / Galanin Receptor Antagonists / M40

M40

Catalog #: 3425
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3425/1
M40
1 Image
Description: Potent, non-selective galanin receptor antagonist
Alternative Names: Galanin (1-13)-Pro-Pro-(Ala-Leu-)2Ala amide

Purity: ≥95%

Product Details
Citations (2)
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Biological Activity

M40 is a potent, non-selective galanin receptor antagonist (Ki values are 1.82 and 5.1 nM at GAL1 and GAL2 respectively) that inhibits galanin (1-29) (Cat. No. 2696) binding in rat brain in vitro (IC50 = 3 - 15 nM). Attenuates the antidepressant effects of fluoxetine (Cat. No. 0927) and blocks galanin-induced food intake in vivo. Also exhibits weak partial agonist activity at peripheral GAL2 receptors at doses > 100 nM.

Technical Data

M.Wt:
1981.33
Formula:
C94H145N23O24
Sequence:
GWTLNSAGYLLGPPPALALA

(Modifications: Ala-20 = C-terminal amide)

Solubility:
Soluble to 1 mg/ml in water
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
143896-17-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Leptin acts via lateral hypothalamic area neurotensin neurons to inhibit orexin neurons by multiple GABA-independent mechanisms.
    Goforth P, Leinninger G, Patterson C, Satin L, Myers M
    J Neurosci, 2014;34(34):11405-15.
  2. Galanin-receptor ligand M40 peptide distinguishes between putative galanin-receptor subtypes.
    Bartfai et al.
    Proc.Natl.Acad.Sci.USA, 1993;90:11287
  3. Gastric effects of galanin and its interaction with leptin on brainstem neuronal activity.
    Yuan et al.
    J.Pharm.Exp.Ther., 2002;301:488
  4. A role for galanin in antidepressant actions with a focus on the dorsal raphe nucleus.
    Lu et al.
    Proc.Natl.Acad.Sci.USA, 2005;102:874

Product Datasheets

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Citations for M40

The citations listed below are publications that use Tocris products. Selected citations for M40 include:

2 Citations: Showing 1 - 2

  1. Involvement of galanin and galanin receptor 1 in nociceptive modulation in the central nucleus of amygdala in normal and neuropathic rats.
    Authors: Li
    Sci Rep  2017;7(1):15317
  2. The cardiac sympathetic co-transmitter galanin reduces acetylcholine release and vagal bradycardia: implications for neural control of cardiac excitability.
    Authors: Herring Et al.
    J Mol Cell Cardiol  2012;52:667

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