Home / NKG2A/CD159a / Human NKG2A/CD159a PE-conjugated Antibody

Human NKG2A/CD159a PE-conjugated Antibody

Catalog #: FAB1059P
39 Citations 1 Review Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
FAB1059P-025
FAB1059P-100
Detection of NKG2A/CD159a in Human PBMCs by Flow Cytometry.
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Citations (39)
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Reviews (1)
Summary Data Examples Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human NKG2A/CD159a PE-conjugated Antibody Summary

Species Reactivity
Human
Specificity
Recognizes the human NKG2A/CD94 heterodimer. It does not recognize the NKG2C/CD94 heterodimer or the CD94 homodimer.
Source
Monoclonal Mouse IgG2A Clone # 131411
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
BaF3 mouse pro-B cell line transfected with human NKG2A and CD94
Formulation
Supplied in a saline solution containing BSA and Sodium Azide.
Label
Phycoerythrin (Excitation= 488 nm, Emission= 565-605 nm)

Applications

Recommended Concentration
Sample
Flow Cytometry
10 µL/106 cells
See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Flow Cytometry Detection of NKG2A/CD159a antibody in Human PBMCs antibody by Flow Cytometry. View Larger

Detection of NKG2A/CD159a in Human PBMCs by Flow Cytometry. Human peripheral blood mononuclear cells (PBMCs) were stained with Mouse Anti-Human NCAM-1/CD56 APC-conjugated Monoclonal Antibody (Catalog # FAB2408A) and either (A) Mouse Anti-Human NKG2A/CD159a PE-conjugated Monoclonal Antibody (Catalog # FAB1059P) or (B) Mouse IgG2APhycoerythrin Isotype Control (Catalog # IC003P). View our protocol for Staining Membrane-associated Proteins.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.

Background: NKG2A/CD159a

NKG2A, also known as CD159a, is a type II transmembrane receptor having a single extracellular lectin-like domain and a cytoplasmic ITIM motif. It associates with CD94 and is expressed on NK cells and some activated T cell populations. The NKG2A/CD94 complex delivers an inhibitory signal upon recognition of its ligand, HLA-E.

Long Name
Natural Killer G2A
Entrez Gene IDs
3821 (Human); 16641 (Mouse); 102121106 (Cynomolgus Monkey)
Alternate Names
CD159 antigen-like family member A; CD159a antigen; CD159a; C-lectin type II protein; killer cell lectin-like receptor subfamily C, member 1; Klrc1; MGC13374; natural killer cell lectin; natural killer group protein 2; NK cell receptor A; NKG2; NKG2-1/B activating NK receptor; NKG2A; NKG2-A; NKG2-A/B type II integral membrane protein; NKG2-A/B-activating NK receptor; NKG2-A/NKG2-B type II integral membrane protein; NKG2AMGC59791; NKG2-B

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Citations for Human NKG2A/CD159a PE-conjugated Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

39 Citations: Showing 1 - 10
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  1. Homeobox containing�1 inhibits liver cancer progression by promoting autophagy as well as inhibiting stemness and immune escape
    Authors: H Zhao, H Jia, Q Han, J Zhang
    Oncol. Rep., 2018-07-10;0(0):.
  2. A Method of Assessment of Human Natural Killer Cell Phenotype and Function in Whole Blood
    Authors: Marisa Market, Gayashan Tennakoon, Juliana Ng, Marlena Scaffidi, Christiano Tanese de Souza, Michael A. Kennedy et al.
    Frontiers in Immunology
  3. Alterations of the NK cell pool in HIV/HCV co-infection
    Authors: DJ Kaczmarek, P Kokordelis, B Krämer, A Glässner, F Wolter, F Goeser, P Lutz, C Schwarze-Z, C Boesecke, CP Strassburg, JK Rockstroh, U Spengler, J Nattermann
    PLoS ONE, 2017-04-05;12(4):e0174465.
  4. Adaptive and Innate Cytotoxic Effectors in Chronic Lymphocytic Leukaemia (CLL) Subjects with Stable Disease
    Authors: Rubino, V;Carriero, F;Palatucci, AT;Giovazzino, A;Leone, S;Nicolella, V;Calabrò, M;Montanaro, R;Brancaleone, V;Pane, F;Chiurazzi, F;Ruggiero, G;Terrazzano, G;
    International journal of molecular sciences
    Species: Human
    Sample Types: Whole Cell
    Applications: Flow Cytometry
  5. Natural killer cell therapy potentially enhances the antitumor effects of bevacizumab plus irinotecan in a glioblastoma mouse model
    Authors: Thi-Anh-Thuy Tran, Young-Hee Kim, Thi-Hoang-Oanh Duong, JayaLakshmi Thangaraj, Tan-Huy Chu, Shin Jung et al.
    Frontiers in Immunology
  6. Defining TCRgammadelta lymphoproliferative disorders by combined immunophenotypic and molecular evaluation
    Authors: A Teramo, A Binatti, E Ciabatti, G Schiavoni, G Tarrini, G Barilà, G Calabretto, C Vicenzetto, VR Gasparini, M Facco, I Petrini, R Grossi, N Pisanti, S Bortoluzzi, B Falini, E Tiacci, S Galimberti, G Semenzato, R Zambello
    Nature Communications, 2022-06-08;13(1):3298.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  7. 3D-organoid culture supports differentiation of human CAR+ iPSCs into highly functional CAR T�cells
    Authors: Z Wang, HP McWilliams, H Reza, JR Ostberg, W Chen, X Wang, C Huynh, V Vyas, WC Chang, R Starr, JR Wagner, B Aguilar, X Yang, X Wu, J Wang, W Chen, E Koelker-Wo, CS Seet, A Montel-Hag, GM Crooks, SJ Forman, CE Brown
    Cell Stem Cell, 2022-03-11;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  8. An NK-like CAR T cell transition in CAR T cell dysfunction
    Authors: Charly R. Good, M. Angela Aznar, Shunichiro Kuramitsu, Parisa Samareh, Sangya Agarwal, Greg Donahue et al.
    Cell
  9. Telomerase Reverse Transcriptase Increases Proliferation and Lifespan of Human NK Cells without Immortalization
    Authors: MA Streltsova, MO Ustiuzhani, EV Barsov, SA Kust, RA Velichinsk, EI Kovalenko
    Biomedicines, 2021-06-09;9(6):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  10. CD6 is a target for cancer immunotherapy
    Authors: JH Ruth, M Gurrea-Rub, KS Athukorala, SM Rasmussen, D Weber, PM Randon, RJ Gedert, ME Lind, MA Amin, PL Campbell, PS Tsou, Y Mao-Draaye, Q Wu, TM Lanigan, VG Keshamouni, NG Singer, F Lin, DA Fox
    JCI Insight, 2021-03-08;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  11. TIM-3 Expression Is Downregulated on Human NK Cells in Response to Cancer Targets in Synergy with Activation
    Authors: TN Dao, S Utturkar, N Atallah La, S Matosevic
    Cancers (Basel), 2020-08-26;12(9):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  12. Microwave ablation of primary breast cancer inhibits metastatic progression in model mice via activation of natural killer cells
    Authors: M Yu, H Pan, N Che, L Li, C Wang, Y Wang, G Ma, M Qian, J Liu, M Zheng, H Xie, L Ling, Y Zhao, X Guan, Q Ding, W Zhou, S Wang
    Cell. Mol. Immunol., 2020-05-08;0(0):.
    Species: Human
    Sample Types: PBMC
    Applications: Flow Cytometry
  13. Phenotypic and Functional Changes in Peripheral Blood Natural Killer Cells in Crohn Disease Patients.
    Authors: Samarani S, Sagala P, Jantchou P, Grimard G, Faure C, Deslandres C, Amre D, Ahmad A
    Mediators Inflamm, 2020-02-19;2020(0):6401969.
    Species: Human
    Sample Types: Whole Cells
    Applications: FLOW, Flow Cytometry
  14. Possible role of highly activated mucosal NK cells against viral respiratory infections in children undergoing haematopoietic stem cell transplantation
    Authors: M Vela, T Del Rosal, A Pérez-Mart, J Valentín, I Casas, F Pozo, F Reinoso-Ba, D Bueno, D Corral, A Méndez-Ech, Y Mozo, C Calvo
    Sci Rep, 2019-12-11;9(1):18792.
    Species: Human
    Sample Types: Nasal Fluid
  15. Cryopreserved Human Natural Killer Cells Exhibit Potent Antitumor Efficacy against Orthotopic Pancreatic Cancer through Efficient Tumor-Homing and Cytolytic Ability (Running Title: Cryopreserved NK Cells Exhibit Antitumor Effect)
    Authors: E Oh, B Min, Y Li, C Lian, J Hong, GM Park, B Yang, SY Cho, YK Hwang, CO Yun
    Cancers (Basel), 2019-07-09;11(7):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  16. Analysis of NK cell clones obtained using interleukin-2 and gene-modified K562 cells revealed the ability of "senescent" NK cells to lose CD57 expression and start expressing NKG2A
    Authors: MA Streltsova, SA Erokhina, LM Kanevskiy, DA Lee, WG Telford, AM Sapozhniko, EI Kovalenko
    PLoS ONE, 2018-12-05;13(12):e0208469.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  17. Altered NKp30, NKp46, NKG2D, and DNAM-1 Expression on Circulating NK Cells Is Associated with Tumor Progression in Human Gastric Cancer
    Authors: B Han, FY Mao, YL Zhao, YP Lv, YS Teng, M Duan, W Chen, P Cheng, TT Wang, ZY Liang, JY Zhang, YG Liu, G Guo, QM Zou, Y Zhuang, LS Peng
    J Immunol Res, 2018-09-03;2018(0):6248590.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  18. Varicella zoster virus productively infects human natural killer cells and manipulates phenotype
    Authors: TM Campbell, BP McSharry, M Steain, TM Ashhurst, B Slobedman, A Abendroth
    PLoS Pathog., 2018-04-30;14(4):e1006999.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  19. Human M2 Macrophages Limit NK Cell Effector Functions through Secretion of TGF-? and Engagement of CD85j
    Authors: SY Nuñez, A Ziblat, F Secchiari, NI Torres, JM Sierra, XL Raffo Irao, RE Araya, CI Domaica, MB Fuertes, NW Zwirner
    J. Immunol., 2017-12-27;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  20. Activated hepatic stellate cells impair NK cell anti-fibrosis capacity through a TGF-?-dependent emperipolesis in HBV cirrhotic patients
    Authors: J Shi, J Zhao, X Zhang, Y Cheng, J Hu, Y Li, X Zhao, Q Shang, Y Sun, B Tu, L Shi, B Gao, FS Wang, Z Zhang
    Sci Rep, 2017-03-14;7(0):44544.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  21. Eomesodermin and T-bet mark developmentally distinct human natural killer cells
    Authors: A Collins, N Rothman, K Liu, SL Reiner
    JCI Insight, 2017-03-09;2(5):e90063.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  22. IL-21-Induced MHC Class II+ NK Cells Promote the Expansion of Human Uncommitted CD4+ Central Memory T Cells in a Macrophage Migration Inhibitory Factor-Dependent Manner
    Authors: Romain Loyon
    J Immunol, 2016-05-27;197(1):85-96.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  23. CD3(bright)CD56(+) T cells associate with pegylated interferon-alpha treatment nonresponse in chronic hepatitis B patients
    Sci Rep, 2016-05-13;6(0):25567.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  24. Alteration of Natural Killer cell phenotype and function in obese individuals.
    Authors: Viel S, Besson L, Charrier E, Marcais A, Disse E, Bienvenu J, Walzer T, Dumontet C
    Clin Immunol, 2016-01-18;177(0):12-17.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  25. Up-regulation of activating and inhibitory NKG2 receptors in allogeneic and autologous hematopoietic stem cell grafts.
    Authors: Picardi A, Mengarelli A, Marino M, Gallo E, Benevolo M, Pescarmona E, Cocco R, Fraioli R, Tremante E, Petti M, De Fabritiis P, Giacomini P
    J Exp Clin Cancer Res, 2015-09-11;34(0):98.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  26. NKP30-B7-H6 Interaction Aggravates Hepatocyte Damage through Up-Regulation of Interleukin-32 Expression in Hepatitis B Virus-Related Acute-On-Chronic Liver Failure.
    Authors: Zou Y, Bao J, Pan X, Lu Y, Liao S, Wang X, Wang G, Lin D
    PLoS ONE, 2015-08-04;10(8):e0134568.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  27. Regulatory Dendritic Cells Restrain NK Cell IFN-gamma Production through Mechanisms Involving NKp46, IL-10, and MHC Class I-Specific Inhibitory Receptors.
    Authors: Spallanzani R, Torres N, Avila D, Ziblat A, Iraolagoitia X, Rossi L, Domaica C, Fuertes M, Rabinovich G, Zwirner N
    J Immunol, 2015-07-31;195(5):2141-8.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  28. Human Induced Pluripotent Stem Cells Are Targets for Allogeneic and Autologous Natural Killer (NK) Cells and Killing Is Partly Mediated by the Activating NK Receptor DNAM-1.
    Authors: Kruse V, Hamann C, Monecke S, Cyganek L, Elsner L, Hubscher D, Walter L, Streckfuss-Bomeke K, Guan K, Dressel R
    PLoS ONE, 2015-05-07;10(5):e0125544.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  29. Overexpression of CD85j in TNBC patients inhibits Cetuximab-mediated NK-cell ADCC but can be restored with CD85j functional blockade.
    Authors: Roberti M, Julia E, Rocca Y, Amat M, Bravo A, Loza J, Colo F, Loza C, Fabiano V, Maino M, Podhorzer A, Fainboim L, Barrio M, Mordoh J, Levy E
    Eur J Immunol, 2015-04-07;45(5):1560-9.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  30. Long-term effect on natural killer cells by interferon-alpha therapy on the outcomes of HCV infection.
    Authors: Hu X, Jiang Y, Li X, Gao Y, Guo X, Chi X, Yan H, Feng J, Zhong J, Sun B, Shao X, Xiao W, Pan Y, Niu J
    J Interferon Cytokine Res, 2013-12-24;34(5):366-75.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  31. Intracellular poly(I:C) initiated gastric adenocarcinoma cell apoptosis and subsequently ameliorated NK cell functions.
    Authors: Qu, Jing, Hou, Zhaohua, Han, Qiuju, Jiang, Wen, Zhang, Cai, Tian, Zhigang, Zhang, Jian
    J Interferon Cytokine Res, 2013-09-13;34(1):52-9.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  32. Natural killer cells are characterized by the concomitantly increased interferon-gamma and cytotoxicity in acute resolved hepatitis B patients.
    Authors: Zhao J, Li Y, Jin L, Zhang S, Fan R, Sun Y, Zhou C, Shang Q, Li W, Zhang Z, Wang F
    PLoS ONE, 2012-11-01;7(11):e49135.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  33. Phenotype markers and cytokine intracellular production by CD8+ gammadelta T lymphocytes do not support a regulatory T profile in Behcet's disease patients and healthy controls.
    Authors: Clemente A, Cambra A, Munoz-Saa I, Crespi C, Pallares L, Juan A, Matamoros N, Julia MR
    Immunol. Lett., 2010-02-16;129(2):57-63.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  34. A novel immunomodulatory mechanism of ribavirin in suppressing natural killer cell function.
    Authors: Ogbomo H, Michaelis M, Altenbrandt B, Doerr HW, Cinatl J
    Biochem. Pharmacol., 2009-08-07;79(2):188-97.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  35. Binding of excreted and/or secreted products of adult hookworms to human NK cells in Necator americanus-infected individuals from Brazil.
    Authors: Teixeira-Carvalho A, Fujiwara RT, Stemmy EJ, Olive D, Damsker JM, Loukas A, Correa-Oliveira R, Constant SL, Bethony JM
    Infect. Immun., 2008-10-06;76(12):5810-6.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  36. Functional impairment in circulating and intrahepatic NK cells and relative mechanism in hepatocellular carcinoma patients.
    Authors: Cai L, Zhang Z, Zhou L, Wang H, Fu J, Zhang S, Shi M, Zhang H, Yang Y, Wu H, Tien P, Wang FS
    Clin. Immunol., 2008-09-27;129(3):428-37.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  37. Isolation and characterization of CD8+ regulatory T cells in multiple sclerosis.
    Authors: Correale J, Villa A
    J. Neuroimmunol., 2008-01-30;195(1):121-34.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  38. Preventing Surgery-Induced NK Cell Dysfunction Using Anti-TGF-beta Immunotherapeutics
    Authors: Marisa Market, Gayashan Tennakoon, Marlena Scaffidi, David P. Cook, Leonard Angka, Juliana Ng et al.
    International Journal of Molecular Sciences
  39. Identification of Human Memory‐Like NK Cells
    Authors: Elena I. Kovalenko, Maria A. Streltsova, Leonid M. Kanevskiy, Sophia A. Erokhina, William G. Telford
    Current Protocols in Cytometry

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Human NKG2A/CD159a PE-conjugated Antibody
By Anonymous on 01/24/2021
Application: Flow Sample Tested: Peripheral blood mononuclear cells (PBMCs) Species: Human
Flow Cytometry Human NKG2A/CD159a PE-conjugated Antibody FAB1059P