Human Lymphotoxin beta R/TNFRSF3 Antibody Summary
Ser28-Met227
Accession # P36941
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: Lymphotoxin beta R/TNFRSF3
Lymphotoxin beta receptor (LT beta R), also known as TNF RIII and TNF R-related protein (TNF Rrp), was originally identified as a transcribed sequence on human chromosome 12p with homology to the TNF receptor superfamily. In the new TNF nomenclature, LT beta R is referred to as TNFRSF3. Human LT beta R cDNA encodes a 435 amino acid (aa) residue type I membrane protein with a putative 30 aa residue signal peptide, a 193 aa residue extracellular domain and a 171 aa residue cytoplasmic domain. The extracellular domain of LT beta R contains four cysteine-rich motif characteristic of the TNF receptor superfamily. The cytoplasmic region of LT beta R share little sequence similarity with other TNF receptor family members, suggesting that different signaling mechanisms may be utilized. LT beta R is expressed in a variety of tissues including visceral and lymphoid tissues. LT beta R is also expressed by cell lines of monocytic, epithelial, and fibroblastic origins but not by T and B lymphocytes. The human and mouse LT beta R share 76% aa sequence homology. The TNF family ligands that have been shown to bind and activate LT beta R include LIGHT (also a ligand for HVEM) and the heterotrimeric lymphotoxin LT alpha 1/ beta 2 or LT alpha 2/ beta 1. Depending on the cell type, activation of LT beta R has been shown to induce NF kappa B activation, chemokine production, growth arrest, and apoptosis. In vivo, LT beta R has been shown to play a critical role in controlling cellular immune functions and lymphoid organogenesis.
- Zhai, Y. et al. (1998) J. Clin. Invest. 102:1142.
- Rennert, P.D. et al. (1998) Immunity 9:71.
- Degli-Esposti, M.A. et al. (1997) J. Immunol 158:1756.
- Mackay, F. et al. (1996) J. Biol. Chem. 271:8618.
- Crowe, P.D. et al. (1994) Science 264:707.
Product Datasheets
Citations for Human Lymphotoxin beta R/TNFRSF3 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 10
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Retinoic Acid and Lymphotoxin Signaling Promote Differentiation of Human Intestinal M Cells
Authors: Siyuan Ding, Yanhua Song, Kevin F. Brulois, Junliang Pan, Julia Y. Co, Lili Ren et al.
Gastroenterology
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Clathrin- and dynamin-dependent endocytosis limits canonical NF-&kappaB signaling triggered by lymphotoxin &beta receptor
Authors: M Maksymowic, M Mi?czy?ska, M Banach-Or?
Cell Commun Signal, 2020-11-04;18(1):176.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot -
TNF-alpha blockade induces IL-10 expression in human CD4+ T cells.
Authors: Evans H, Roostalu U, Walter G, Gullick N, Frederiksen K, Roberts C, Sumner J, Baeten D, Gerwien J, Cope A, Geissmann F, Kirkham B, Taams L
Nat Commun, 2014-01-01;5(0):3199.
Species: Human
Sample Types: Whole Cells
Applications: Neutralization -
Mitogenic signalling and the p16INK4a-Rb pathway cooperate to enforce irreversible cellular senescence.
Authors: Takahashi A, Ohtani N, Yamakoshi K, Iida S, Tahara H, Nakayama K, Nakayama KI, Ide T, Saya H, Hara E
Nat. Cell Biol., 2006-10-08;8(11):1291-7.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot -
Hepatitis C virus NS5A-regulated gene expression and signaling revealed via microarray and comparative promoter analyses.
Authors: Girard S, Vossman E, Misek DE, Podevin P, Hanash S, Brechot C, Beretta L
Hepatology, 2004-09-01;40(3):708-18.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot -
LIGHT, a member of the tumor necrosis factor ligand superfamily, prevents tumor necrosis factor-alpha-mediated human primary hepatocyte apoptosis, but not Fas-mediated apoptosis.
Authors: Hikichi Y, Tsuji I, Shintani Y
J. Biol. Chem., 2002-10-18;277(51):50054-61.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Cholesterol restricts lymphotoxin beta receptor-triggered NF-kappa B signaling
Authors: Magdalena Banach-Orłowska, Renata Wyszyńska, Beata Pyrzyńska, Małgorzata Maksymowicz, Jakub Gołąb, Marta Miączyńska
Cell Communication and Signaling
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The topology of lymphotoxin ? receptor accumulated upon endolysosomal dysfunction dictates the NF-?B signaling outcome
Authors: M Banach-Or?, K Jastrz?bsk, J Cendrowski, M Maksymowic, K Wojciechow, M Korosty?sk, D Moreau, J Gruenberg, M Miaczynska
J. Cell. Sci., 2018-11-21;0(0):.
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Induction of the Alternative NF-kappa B Pathway by Lymphotoxin alpha beta (LT alpha beta ) Relies on Internalization of LT beta Receptor
Authors: Corinne Ganeff, Caroline Remouchamps, Layla Boutaffala, Cécile Benezech, Géraldine Galopin, Sarah Vandepaer et al.
Molecular and Cellular Biology
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Non-canonical NF-kappa B signalling and ETS1/2 cooperatively drive C250T mutant TERT promoter activation
Authors: Yinghui Li, Qi-Ling Zhou, Wenjie Sun, Prashant Chandrasekharan, Hui Shan Cheng, Zhe Ying et al.
Nature Cell Biology
FAQs
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Is the bioassay for Catalog # AF629 indicative of agonistic or antagonistic function of the antibody?
The assay is indicative of agonistic function.
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