Human Lymphotoxin beta /TNFSF3 Antibody

Catalog #: MAB1684
2 Citations Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
MAB1684
MAB1684-SP

Product Details

Citations (2)

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Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human Lymphotoxin beta /TNFSF3 Antibody Summary

Species Reactivity

Human

Specificity

Detects human Lymphotoxin alpha beta heterotrimers in direct ELISAs and Western blots. This antibody detects an epitope in the Lymphotoxin beta subunit. In direct ELISAs, this antibody does not cross-react with recombinant human (rh) Lymphotoxin alpha, rhAPRIL, rhBAFF, rhTNF‑ alpha, rhTWEAK, rhEDA‑A2, rhEDA, rhTRAIL, rhVEGI, rhTRANCE, rhFas Ligand, or rhOX40 Ligand.

Source

Monoclonal Mouse IgG_2B Clone # 135105

Purification

Protein A or G purified from hybridoma culture supernatant

Immunogen

S. frugiperda insect ovarian cell line Sf 21-derived recombinant human Lymphotoxin alpha / beta

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Applications

Recommended Concentration

Sample

Western Blot

1 µg/mL

Human Lymphotoxin beta /TNFSF3

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Reconstitution

Reconstitute at 0.5 mg/mL in sterile PBS.

Shipping

Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Lymphotoxin beta/TNFSF3

Lymphotoxin beta is a type II transmembrane protein member of the TNF ligand superfamily and is now designated TNFSF3. Lymphotoxin beta associates with Lymphotoxin alpha to form two types of heterotrimers, Lymphotoxin alpha ₁ beta ₂ and Lymphotoxin alpha ₂ beta ₁. Lymphotoxin beta is expressed by activated CD4 T cells, unpolarized IL‑2‑secreting effector T cells, and Th1 effector cells.

Long Name

Lymphotoxin beta

Entrez Gene IDs

4050 (Human); 102135554 (Cynomolgus Monkey)

Alternate Names

LTB; lymphotoxin beta (TNF superfamily, member 3); Lymphotoxin beta; lymphotoxin-beta; p33; TNFCTNF-C; TNFSF3; TNFSF3LT-beta; Tumor necrosis factor C; Tumor necrosis factor ligand superfamily member 3

Product Datasheets

Product Datasheet

COA

SDS

Related Research Areas

Citations for Human Lymphotoxin beta /TNFSF3 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

2 Citations: Showing 1 - 2
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Microarray analysis of gene expression by microdissected epidermis and dermis in mycosis fungoides and adult T-cell leukemia/lymphoma.
Authors: Hashikawa K, Yasumoto S, Nakashima K, Arakawa F, Kiyasu J, Kimura Y, Saruta H, Nakama T, Yasuda K, Tashiro K, Kuhara S, Hashimoto T, Ohshima K
Int J Oncol, 2014-06-26;45(3):1200-8.
Species: Human
Sample Types: Whole Tissue
Applications: IHC-P
Lymphotoxin-alphabeta heterotrimers are cleaved by metalloproteinases and contribute to synovitis in rheumatoid arthritis.
Authors: Young J, Yu X, Wolslegel K
Cytokine, 2010-03-31;51(1):78-86.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot