Human KOR Antibody

Catalog #: MAB38951
1 Citation Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
MAB38951
MAB38951-SP

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Human KOR Antibody Summary

Species Reactivity

Human

Specificity

Detects human KOR. Stains human KOR transfectants but not irrelevant transfectants.

Source

Monoclonal Mouse IgG₁ Clone # 387310

Purification

Protein A or G purified from hybridoma culture supernatant

Immunogen

NS0 mouse myeloma cell line transfected with human KOR
Met1-Val380
Accession # P41145

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Label

Unconjugated

Applications

Recommended Concentration

Sample

Immunohistochemistry

8-25 µg/mL

See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Immunohistochemistry

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KOR in Human Brainstem. KOR was detected in immersion fixed paraffin-embedded sections of human brainstem (medulla) using 15 µg/mL Mouse Anti-Human KOR Monoclonal Antibody (Catalog # MAB38951) overnight at 4 °C. Before incubation with the primary antibody tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-Basic (Catalog # CTS013). Tissue was stained with the Anti-Mouse HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS002) and counterstained with hematoxylin (blue). View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.

Reconstitution Calculator

Preparation and Storage

Reconstitution

Reconstitute at 0.5 mg/mL in sterile PBS.

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: KOR

Kappa Opioid Receptor (KOR) is a 45 kDa 7TM opioid receptor that is primarily expressed in the central nervous system and peripheral visceral pain sensory nerves. Following ligation by dynorphin peptides, KOR signaling induces analgesia, dysphoria, diuresis, and increased feeding desire. KOR also exerts neuroprotective and anti-inflammatory effects. Human KOR shares 94% amino acid sequence identity with mouse and rat KOR.

Long Name

Kappa Opioid Receptor

Entrez Gene IDs

4986 (Human); 18387 (Mouse); 29335 (Rat)

Alternate Names

kappa opioid receptor; kappa-type opioid receptor; KOR; K-OR-1; KOR-1; Opiate receptor, kappa-1; opioid receptor, kappa 1; OPRK; OPRK1; Oprk2; R21

Product Datasheets

Product Datasheet

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Citation for Human KOR Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

1 Citation: Showing 1 - 1