Human ING1 Antibody Summary
Arg70-Ala184
Accession # Q9UK53
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
![ING1 antibody in Human Pancreas by Immunohistochemistry (IHC-P). ING1 antibody in Human Pancreas by Immunohistochemistry (IHC-P).](https://resources.rndsystems.com/images/datasheets/antibody/ING1_MAB57581_Immunohistochemistry_10633.jpg)
ING1 in Human Pancreas. ING1 was detected in immersion fixed paraffin-embedded sections of human pancreas using Human ING1 Monoclonal Antibody (Catalog # MAB57581) at 15 µg/mL overnight at 4 °C. Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-Basic (Catalog # CTS013). Tissue was stained using the Anti-Mouse HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS002) and counterstained with hematoxylin (blue). Specific staining was localized to exocrine cell nuclei. View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: ING1
ING1 (inhibitor of growth-1) is a member of the ING family of tumor suppressive and apoptosis-promoting epigenetic regulators of chromatin structure. They interact with and alter the ratio of pro- and anti-apoptotic Bcl-2 family members. The p53 tumor suppressor and its downstream targets can potentiate ING1-induced apoptosis. Human isoforms p33ING1, p24ING1c, p33ING1b and p47ING1a vary in N-terminal sequence, resulting in 279, 210, 235 and 422 aa proteins, respectively. The sequence used as an immunogen is common to all isoforms, and shares 83% and 81% amino acid (aa) identity with mouse and rat ING1, respectively.
Product Datasheets
Citation for Human ING1 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
1 Citation: Showing 1 - 1
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A Unique pH-Dependent Recognition of Methylated Histone H3K4 by PPS and DIDO
Authors: Adam H. Tencer, Jovylyn Gatchalian, Brianna J. Klein, Abid Khan, Yi Zhang, Brian D. Strahl et al.
Structure
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