Human IL-22 Antibody Summary
Ala34-Ile179
Accession # Q9GZX6
Applications
Human IL-22 Sandwich Immunoassay
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: IL-22
Interleukin-22 (IL-22), also known as IL-10-related T cell-derived inducible factor (IL-TIF) was initially identified as a gene induced by IL-9 in mouse T cells and mast cells. Human IL-22 cDNA encodes a 179 amino acid (aa) residue protein with a putative 33 aa signal peptide that is cleaved to generate a 147 aa mature protein that shares approximately 79% and 22% aa sequence identity with mouse IL-22 and human IL-10, respectively. The human IL-22 gene is localized to chromosome 12q15. Although it exists as a single copy gene in human and in many mouse strains, the mouse IL-22 gene is duplicated in some mouse strains including C57B1/6, FVB and 129. The two mouse genes designated IL-TIF alpha and IL-TIF beta, share greater than 98% sequence homology in their coding region. IL-22 has been shown to activate
STAT‑1 and STAT-3 in several hepatoma cell lines and upregulate the production of acute phase proteins. IL-22 is produced by normal T cells upon anti-CD3 stimulation in humans. Mouse IL-22 expression is also induced in various organs upon lipopolysaccharide injection, suggesting that IL-22 may be involved in inflammatory responses. The functional IL-22 receptor complex consists of two receptor subunits, IL-22 R (previously an orphan receptor named CRF2-9) and
IL-10 R beta (previously known as CRF2-4), belonging to the class II cytokine receptor family.
- Dumoutier, L. et al., (2000) J. Immunol. 164:1814.
- Xie, M-H. et al., (2000) J. Biol. Chem. 275:31335.
- Dumoutier, L. et al., (2000) PNAS 97:10144.
- Kotenko, S.V. et al., (2001) J. Biol. Chem. 276:2725.
Product Datasheets
Citations for Human IL-22 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 8
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T(H)17 cells promote microbial killing and innate immune sensing of DNA via interleukin 26
Authors: Stephan Meller, Jeremy Di Di Domizio, Kui S Voo, Heike C Friedrich, Georgios Chamilos, Dipyaman Ganguly et al.
Nature Immunology
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A novel variant in AIRE causing a rare, non‑classical autoimmune polyendocrine syndrome type 1
Authors: Wen‑Bin Zheng, Lu‑Jiao Li, Di‑Chen Zhao, Ou Wang, Yan Jiang, Wei‑Bo Xia et al.
Molecular Medicine Reports
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Th17 Responses to Collagen Type V, k alpha 1-Tubulin, and Vimentin Are Present Early in Human Development and Persist Throughout Life
Authors: Jeremy A Sullivan, Ewa Jankowska-Gan, Subramanya Hegde, Matthew A Pestrak, Vrushali V Agashe, Arick C Park et al.
American Journal of Transplantation
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Machine-learning algorithms define pathogen-specific local immune fingerprints in peritoneal dialysis patients with bacterial infections
Authors: J Zhang, IM Friberg, A Kift-Morga, G Parekh, MP Morgan, AR Liuzzi, CY Lin, KL Donovan, CS Colmont, PH Morgan, P Davis, I Weeks, DJ Fraser, N Topley, M Eberl
Kidney Int, 2017-03-17;0(0):.
Species: Human
Sample Types: Peritoneal Effluent
Applications: ELISA Development (Capture) -
IL-10 suppresses Th17 cells and promotes regulatory T cells in the CD4+ T cell population of rheumatoid arthritis patients.
Authors: Heo YJ, Joo YB, Oh HJ, Park MK, Heo YM, Cho ML, Kwok SK, Ju JH, Park KS, Cho SG, Park SH, Kim HY, Min JK
Immunol. Lett., 2009-11-04;127(2):150-6.
Species: Human
Sample Types: Cell Culture Supernates
Applications: ELISA Development -
IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia.
Authors: Aujla SJ, Chan YR, Zheng M, Fei M, Askew DJ, Pociask DA, Reinhart TA, McAllister F, Edeal J, Gaus K, Husain S, Kreindler JL, Dubin PJ, Pilewski JM, Myerburg MM, Mason CA, Iwakura Y, Kolls JK
Nat. Med., 2008-02-10;14(3):275-81.
Species: Mouse
Sample Types: Whole Cells
Applications: ELISpot Development -
Expanded IL-22+ Group 3 Innate Lymphoid Cells and Role of Oxidized LDL-C in the Pathogenesis of Axial Spondyloarthritis with Dyslipidaemia
Authors: Hong Ki Min, Jeonghyeon Moon, Seon-Yeong Lee, A Ram Lee, Chae Rim Lee, Jennifer Lee et al.
Immune Network
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CD28 Autonomous Signaling Orchestrates IL-22 Expression and IL-22-Regulated Epithelial Barrier Functions in Human T Lymphocytes
Authors: Martina Kunkl, Carola Amormino, Simone Frascolla, Manolo Sambucci, Marco De Bardi, Silvana Caristi et al.
Frontiers in Immunology
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