Home / IL-13 R alpha 2 / Human IL-13 R alpha 2 Antibody

Human IL-13 R alpha 2 Antibody

Catalog #: MAB6141
2 Citations 1 Review Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
MAB6141-SP
MAB6141-100
MAB6141-500
Product Details
Citations (2)
FAQs
Supplemental Products
Reviews (1)
Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human IL-13 R alpha 2 Antibody Summary

Species Reactivity
Human
Specificity
Detects human IL-13 R alpha 2 in ELISAs. In sandwich ELISAs, no cross-reactivity or interference was observed with recombinant human (rh) IL-4 R, rhIL-5 R alpha, rhIL‑9 R, rhIL‑13, rhIL-13 R alpha 1, recombinant mouse (rm) IL-13, rmIL-13 R alpha 1, or rmIL-13 R alpha 2.
Source
Monoclonal Mouse IgG1 Clone # 83807
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
Mouse myeloma cell line NS0-derived recombinant human IL‑13 R alpha 2
Cys22-Leu342
Accession # Q14627
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Applications

Recommended Concentration
Sample

Human IL-13 R alpha 2 Sandwich Immunoassay

Recommended Concentration
Reagent
ELISA Capture (Matched Antibody Pair)
2-8 µg/mL 

Use in combination with:

Detection Reagent: Human IL‑13 R alpha 2 Biotinylated Antibody (Catalog # BAF614)

Standard: Recombinant Human IL-13 R alpha 2 Fc Chimera (NS0), CF (Catalog # 614-INS)

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Reconstitute at 0.5 mg/mL in sterile PBS.
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Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: IL-13 R alpha 2

Two type I membrane proteins belonging to the hemopoietin receptor family have been cloned and shown to bind IL-13 with high affinity. The lower affinity IL-13 binding protein is now referred to as IL-13 R alpha 1 and is also known as CD213a. IL-13 R alpha 1 combines with IL-4 R alpha to form a high affinity receptor complex capable of transducing an IL-13-dependent proliferative signal. The higher affinity IL-13 binding protein, now referred to as IL-13 R alpha 2, does not induce a signal and acts as a decoy receptor (1, 2).

References
  1. Wood, N. et al. (2003) J. Exp. Med. 197:703.
  2. Kelly-Welch, A. et al. (2003) Science 300:1527.
Long Name
Interleukin 13 Receptor alpha 2
Entrez Gene IDs
3598 (Human); 16165 (Mouse)
Alternate Names
cancer/testis antigen 19; CD213a2 antigen; CD213a2; CT19; IL-13 R alpha 2; IL-13 receptor subunit alpha-2; IL13BP; IL13R alpha 2; IL-13R subunit alpha-2; IL13R; IL-13R; IL13RA2; IL-13Ra2; IL-13R-alpha-2; interleukin 13 binding protein; interleukin 13 receptor alpha 2 chain; interleukin 13 receptor, alpha 2; interleukin-13 receptor subunit alpha-2; Interleukin-13-binding protein

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Citations for Human IL-13 R alpha 2 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

2 Citations: Showing 1 - 2
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  1. Interleukin (IL)-4, IL-13, and IL-17A differentially affect the profibrotic and proinflammatory functions of fibrocytes from asthmatic patients.
    Authors: Bellini A, Marini MA, Bianchetti L, Barczyk M, Schmidt M, Mattoli S
    Mucosal Immunol, 2011-12-21;5(2):140-9.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  2. Interleukin-13 receptor alpha2 chain: a potential biomarker and molecular target for ovarian cancer therapy.
    Authors: Kioi M, Kawakami M, Shimamura T, Husain SR, Puri RK
    Cancer, 2006-09-15;107(6):1407-18.
    Species: Human
    Sample Types: Serum, Whole Tissue
    Applications: ELISA Development, IHC-P

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Human IL‑13 R alpha 2 Antibody
By Anonymous on 11/03/2017
Application: Flow Sample Tested: HEK293 human embryonic kidney cell line Species: Human
Flow Cytometry Human IL‑13 R alpha 2 Antibody MAB6141