Human HLA-DR PerCP-conjugated Antibody

Catalog #: FAB4869C
5 Citations Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
FAB4869C-100
FAB4869C-025

Detection of HLA-DR in Human Blood Lymphocytes by Flow Cytometry.

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All HLA-DR Antibodies

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Citations (5)

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Summary Data Examples Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human HLA-DR PerCP-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects human HLA‑DR.

Source

Monoclonal Mouse IgG₁ Clone # L203

Purification

Protein A or G purified from hybridoma culture supernatant

Immunogen

RPMI 8866 human lymphoblastoid cells
Accession # P01903

Formulation

Supplied in a saline solution containing BSA and Sodium Azide.

Label

PerCP (Peridinin-chlorophyll Protein Complex) (Excitation= 482 and 564 nm, Emission= 675 nm)

Applications

Recommended Concentration

Sample

Flow Cytometry

10 µL/10⁶ cells

See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Flow Cytometry

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Detection of HLA-DR in Human Blood Lymphocytes by Flow Cytometry. Human peripheral blood lymphocytes were stained with (A) Mouse Anti-Human HLA-DR PerCP-conjugated Monoclonal Antibody (Catalog # FAB4869C) or (B) isotype control antibody (Catalog # IC002C) and Mouse anti-Human CD19 CFS-conjugated Monoclonal Antibody (Catalog # FAB4867F). View our protocol for Staining Membrane-associated Proteins.

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Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze.

12 months from date of receipt, 2 to 8 °C as supplied.

Background: HLA-DR

HLA-DR is a transmembrane human major histocompatibility complex 2 (MHC II) family member and consists of a 34 kDa (alpha) subunit and one of several 28 kDa (beta) subunits. HLA-DR is expressed primarily by B cells and dendritic cells (DC), in which it binds peptides derived from internalized and processed antigenic proteins. It presents these peptides on the cell surface for recognition by the T cell receptor on CD4⁺ T cells. This interaction is central to antigen specificity in the adaptive immune response. HLA-DR alleles, polymorphisms, and aberrant expression are linked to a variety of diseases including autoimmunity and cancer.

Long Name

Major Histocompatibility Complex Class II DR

Entrez Gene IDs

3122 (Human)

Alternate Names

FLJ51114; histocompatibility antigen HLA-DR alpha; HLA class II histocompatibility antigen, DR alpha chain; HLADR; HLA-DR; HLA-DRA; HLA-DRA1; major histocompatibility complex, class II, DR alpha; MHC cell surface glycoprotein; MHC class II antigen DRA; MHC Class II DR; MLRW

Product Datasheets

Product Datasheet

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Related Research Areas

Citations for Human HLA-DR PerCP-conjugated Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

5 Citations: Showing 1 - 5
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Characterization of Biomarkers of Thrombo-Inflammation in Patients with First-Diagnosed Atrial Fibrillation
Authors: Friebel, J;Wegner, M;Blöbaum, L;Schencke, PA;Jakobs, K;Puccini, M;Ghanbari, E;Lammel, S;Thevathasan, T;Moos, V;Witkowski, M;Landmesser, U;Rauch-Kröhnert, U;
International journal of molecular sciences
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry
Phosphonate-Modified Cellulose Nanocrystals Potentiate the Th1 Polarising Capacity of Monocyte-Derived Dendritic Cells via GABA-B Receptor
Authors: M Beki?, M Vasiljevi?, D Stojanovi?, V Kokol, D Mihajlovi?, D Vu?evi?, P Uskokovi?, M ?oli?, S Tomi?
International Journal of Nanomedicine, 2022-07-23;17(0):3191-3216.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry
Down-regulation of complement receptors on the surface of host monocyte even as in vitro complement pathway blocking interferes in dengue infection.
Authors: Marinho C, Azeredo E, Torrentes-Carvalho A, Marins-Dos-Santos A, Kubelka C, de Souza L, Cunha R, de-Oliveira-Pinto L
PLoS ONE, 2014-07-25;9(7):e102014.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry
Ex vivo tetramer staining and cell surface phenotyping for early activation markers CD38 and HLA-DR to enumerate and characterize malaria antigen-specific CD8+ T-cells induced in human volunteers immunized with a Plasmodium falciparum adenovirus-vectored malaria vaccine expressing AMA1.
Authors: Schwenk, Robert, Banania, Glenna, Epstein, Judy, Kim, Yohan, Peters, Bjoern, Belmonte, Maria, Ganeshan, Harini, Huang, Jun, Reyes, Sharina, Stryhn, Anette, Ockenhouse, Christia, Buus, Soren, Richie, Thomas L, Sedegah, Martha
Malar J, 2013-10-29;12(0):376.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry
Vemurafenib enhances MHC induction in BRAF homozygous melanoma cells.
Authors: Sapkota B, Hill C, Pollack B
Oncoimmunology, 2013-01-01;2(1):e22890.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry