Human EGR1 Antibody Summary
Gln282-Ser433
Accession # P18146
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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EGR1 in Human Prostate Cancer Tissue. EGR1 was detected in immersion fixed paraffin-embedded sections of human prostate cancer tissue using 15 µg/mL Rat Anti-Human EGR1 Monoclonal Antibody (Catalog # MAB2818) overnight at 4 °C. Before incubation with the primary antibody tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-Basic (Catalog # CTS013). Tissue was stained with the Anti-Rat HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS017) and counterstained with hematoxylin (blue). View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.
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EGR1 in Human Prostate Cancer Tissue. EGR1 was detected in immersion fixed paraffin-embedded sections of human prostate cancer tissue using 15 µg/mL Rat Anti-Human EGR1 Monoclonal Antibody (Catalog # MAB2818) overnight at 4 °C. Before incubation with the primary antibody tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-Basic (Catalog # CTS013). Tissue was stained with the Anti-Rat HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS017) and counterstained with hematoxylin (blue). View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: EGR1
Early Growth Response 1, (EGR1) belongs to the EGR family of zinc finger transcription factors and regulates the expression of several tumor suppressors. Its expression is induced by diverse signals that initiate growth and differentiation. EGR1 suppresses or activates cell growth depending on the tumor type. Within the region that includes its three zinc finger domains, human EGR1 shares 99% aa sequence identity with mouse and rat EGR1.
Product Datasheets
Citations for Human EGR1 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Activity-Dependent Reconnection of Adult-Born Dentate Granule Cells in a Mouse Model of Frontotemporal Dementia
Authors: Julia Terreros-Roncal, Miguel Flor-García, Elena P. Moreno-Jiménez, Noemí Pallas-Bazarra, Alberto Rábano, Nirnath Sah et al.
The Journal of Neuroscience
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MicroRNA?181 exerts an inhibitory role during renal fibrosis by targeting early growth response factor?1 and attenuating the expression of profibrotic markers
Authors: X Zhang, Z Yang, Y Heng, C Miao
Mol Med Rep, 2019-02-18;0(0):.
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