Home / C1qR1/CD93 / Human C1qR1/CD93 Antibody

Human C1qR1/CD93 Antibody

Catalog #: MAB23791
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
MAB23791
MAB23791-SP
Product Details
Citations (2)
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Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human C1qR1/CD93 Antibody Summary

Species Reactivity
Human
Specificity
Detects human C1q R1/CD93 in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross‑reactivity with recombinant mouse C1q R1 is observed.
Source
Monoclonal Mouse IgG1 Clone # 273107
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
Mouse myeloma cell line NS0-derived recombinant human C1q R1/CD93
Ala24-Lys580
Accession # Q9NPY3
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Applications

Recommended Concentration
Sample
Western Blot
1 µg/mL
Recombinant Human C1q R1/CD93 under non-reducing conditions only
Flow Cytometry
2.5 µg/106 cells
Human whole blood monocytes
CyTOF-ready
Ready to be labeled using established conjugation methods. No BSA or other carrier proteins that could interfere with conjugation.
 

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Reconstitute at 0.5 mg/mL in sterile PBS.
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Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: C1qR1/CD93

C1q R1 is also known as C1q Rp, Collectin Receptor, and AA4 antigen, and is designated CD93. C1q R1 mediates enhanced phagocytosis by monocytes and macrophages upon interaction with soluble defense collagens including C1q, MBL, and SP-A (1, 2). It is a type I transmembrane glycoprotein expressed on endothelial cells, hematopoietic progenitor cells, platelets, and cells of myeloid origin. C1q R1 has also been identified as a stem cell marker (3, 4).

References
  1. Kim, T.S. et al. (2000) Mol. Immunol. 37:377.
  2. Dean, Y.D. et al. (2001) Eur. J. Immunol. 31:1370.
  3. Petrenko, O. et al. (1999) Immunity 10:691.
  4. Danet, G.H. et al. (2002) Proc. Natl. Acad. Sci. USA 99:10441.
Long Name
Complement Component C1q Receptor
Entrez Gene IDs
22918 (Human); 17064 (Mouse); 84398 (Rat)
Alternate Names
AA4 Antigen; C1q R1; C1q receptor 1; C1q Rp; C1q/MBL/SPA receptor; C1qR(P); C1qR1; C1qRp; CD93 antigenC1qR; CD93 molecule; CD93; CDw93C1QR1; Collectin Receptor; Complement component 1 q subcomponent receptor 1; complement component 1, q subcomponent, receptor 1; complement component C1q receptor; dJ737E23.1; ECSM3; Ly68; Matrix-remodeling-associated protein 4; matrix-remodelling associated 4; MXRA4

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Citations for Human C1qR1/CD93 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

2 Citations: Showing 1 - 2
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  1. Significance of Soluble CD93 in Type 2 Diabetes as a Biomarker for Diabetic Nephropathy: Integrated Results from Human and Rodent Studies
    Authors: M Lee, HS Park, MY Choi, HZ Kim, SJ Moon, JY Ha, A Choi, YW Park, JS Park, EC Shin, CW Ahn, S Kang
    J Clin Med, 2020-05-08;9(5):.
    Species: Mouse
    Sample Types: Serum
    Applications: ELISA (Capture)
  2. Soluble CD93 levels in patients with acute myocardial infarction and its implication on clinical outcome.
    Authors: Youn J, Yu H, Jeon J, Lee H, Jang Y, Park Y, Park Y, Shin E, Ha J
    PLoS ONE, 2014-05-06;9(5):e96538.
    Species: Human
    Sample Types: Serum
    Applications: ELISA Development (Capture)

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