Does this Biosimilar antibody have the same sequence as the therapeutic antibody?

The Biosimilar antibody has the same variable region and constant region sequence as the therapeutic antibody, except for Catalog numbers MAB9677, MAB9575, MAB9577, MAB9589, and their conjugates. These four antibodies have the same variable region as the Biosimilar, but not the same constant region.

What is a Biosimilar antibody?

A Biosimilar antibody is a non-therpeutic, recombinantly-expressed antibody which has the same sequence as the corresponding therapeutic antibody. It is for research use only. The nomenclature of the Biosimilar antibody includes the name of the therapeutic antibody. For example, Catalog # MAB9577 is called Human EGFR (Research Grade CetuxiMab Biosimilar) antibody.

Human APP/Protease Nexin II (Research Grade Aducanumab Biosimilar) Antibody

Catalog #: MAB9710 Datasheet / COA / SDS

Recombinant Monoclonal Antibody For Research Use Only

Catalog #	Availability	Size / Price	Qty
MAB9710-100
MAB9710-SP

Detection of APP/Protease Nexin II (Aducanumab) in Human PBMC by Flow Cytometry

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Human APP/Protease Nexin II (Research Grade Aducanumab Biosimilar) Antibody Summary

Species Reactivity

Human

Specificity

Detects human APP/Protease Nexin II based on Aducanumab therapeutic antibody. This non-therapeutic antibody uses the same variable region sequence as the therapeutic antibody Aducanumab. This product is for research use only.

Source

Monoclonal Human IgG1 Clone # Hu15

Immunogen

Human APP/Protease Nexin II

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. See Certificate of Analysis for details.
*Small pack size (-SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Endotoxin Level

<0.100 EU per 1 µg of the antibody by the LAL method.

Label

Unconjugated

Applications

Recommended Concentration

Sample

Flow Cytometry

0.25 µg/10⁶ cells

See below

CyTOF-ready

Ready to be labeled using established conjugation methods. No BSA or other carrier proteins that could interfere with conjugation.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Flow Cytometry

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Detection of APP/Protease Nexin II (Aducanumab) in Human PBMC by Flow Cytometry Human peripheral blood mononuclear cells (PBMCs) were stained with (A) Human Anti-Human APP/Protease Nexin II (Aducanumab Biosimilar) Monoclonal Antibody (Catalog # MAB9710) or (B) no primary antibody, followed by APC-conjugated Anti-Human IgG Secondary Antibody (Catalog # F0135) and Mouse anti-Human CD14 PE-conjugated antibody (Catalog # FAB3832P). View our protocol for Staining Membrane-associated Proteins.

Reconstitution Calculator

Preparation and Storage

Reconstitution

Reconstitute at 0.5 mg/mL in sterile PBS. For liquid material, refer to CoA for concentration.

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C

Stability & Storage

Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Background: APP

Aducanumab is a biosimilar directed against the extracellular domain of APP/Protease Nexin II. This product constitutes the immunogen used for the anti-Idiotype catalog number MAB9545.

Long Name

Amyloid Precursor Protein

Entrez Gene IDs

351 (Human); 11820 (Mouse)

Alternate Names

amyloid beta (A4) precursor protein-binding, family B, member 2; amyloid beta A4 precursor protein-binding family B member 2; Amyloid beta precursor protein; Amyloid beta; APP; beta Amyloid; Protease Nexin II

Product Datasheets

Product Datasheet

COA

SDS

Related Research Areas

FAQs

Does this Biosimilar antibody have the same sequence as the therapeutic antibody?
- The Biosimilar antibody has the same variable region and constant region sequence as the therapeutic antibody, except for Catalog numbers MAB9677, MAB9575, MAB9577, MAB9589, and their conjugates. These four antibodies have the same variable region as the Biosimilar, but not the same constant region.
What is a Biosimilar antibody?
- A Biosimilar antibody is a non-therpeutic, recombinantly-expressed antibody which has the same sequence as the corresponding therapeutic antibody. It is for research use only. The nomenclature of the Biosimilar antibody includes the name of the therapeutic antibody. For example, Catalog # MAB9577 is called Human EGFR (Research Grade CetuxiMab Biosimilar) antibody.

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