Human AGTR-2 APC-conjugated Antibody

Catalog #: FAB3659A
2 Citations Datasheet / COA / SDS

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FAB3659A

Detection of AGTR‑2 in NS0 Mouse Cell Line by Flow Cytometry.

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All AGTR-2 Antibodies

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Citations (2)

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Human AGTR-2 APC-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects human AGTR‑2. Stains human AGTR-2-transfected cells but not irrelevant transfectants.

Source

Monoclonal Mouse IgG_2B Clone # 364805

Purification

Protein A or G purified from hybridoma culture supernatant

Immunogen

HEK293 human embryonic kidney cell line transfected with human AGTR-2
Met1-Ser363
Accession # P50052

Formulation

Supplied in a saline solution containing BSA and Sodium Azide.

Label

Allophycocyanin (Excitation= 620-650 nm, Emission= 660-670 nm)

Applications

Recommended Concentration

Sample

Flow Cytometry

10 µL/10⁶ cells

See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Flow Cytometry

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Detection of AGTR‑2 in NS0 Mouse Cell Line by Flow Cytometry. NS0 mouse myeloma cell line was stained with Mouse Anti-Human AGTR-2 APC-conjugated Monoclonal Antibody (Catalog # FAB3659A, filled histogram) or isotype control antibody (Catalog # IC0041A, open histogram). View our protocol for Staining Membrane-associated Proteins.

Reconstitution Calculator

Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store the unopened product at 2 - 8° C. Do not use past expiration date. Protect from light.

Background: AGTR-2

AGTR-2, also known as AT2, is a 7-transmembrane protein that belongs to family 1 of G protein-coupled receptors. Both AGTR-2 and AGTR‑1 bind Angiotensin II and function in the control of hemodynamics. In contrast to AGTR‑1, which promotes vasoconstriction and cell proliferation, AGTR-2 inhibits growth and promotes apoptosis. In addition, Angiotensin II-induced AGTR-2 signaling induces the release of nitric oxide in the heart, kidney, and brain and participates in tissue morphogenesis and repair. Human AGTR-2 shares 92% amino acid sequence identity with mouse and rat AGTR-2.

Long Name

Angiostensin II Type 2 Receptor

Entrez Gene IDs

186 (Human); 11609 (Mouse); 24182 (Rat)

Alternate Names

AGTR2; AGTR-2; Angiostensin Receptor; angiotensin II receptor, type 2; Angiotensin II type-2 receptor; angiotensin receptor 2; AT2; AT2ATGR2; AT2R; MRX88; MRX88type-2 angiotensin II receptor

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Product Datasheet

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Citations for Human AGTR-2 APC-conjugated Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

2 Citations: Showing 1 - 2
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Data supporting that adipose-derived mesenchymal stem/stromal cells express angiotensin II receptors in situ and in vitro
Authors: LV Ageeva, VY Sysoeva, PA Tyurin-Kuz, GV Sharonov, DT Dyikanov, DV Stambolsky, NI Kalinina
Data Brief, 2017-11-21;16(0):327-333.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry
Local angiotensin II promotes adipogenic differentiation of human adipose tissue mesenchymal stem cells through type 2 angiotensin receptor
Authors: VY Sysoeva, LV Ageeva, PA Tyurin-Kuz, GV Sharonov, DT Dyikanov, NI Kalinina, VA Tkachuk
Stem Cell Res, 2017-11-03;25(0):115-122.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry