Human ACE-2 Biotinylated Antibody Summary
Gln18-Ser740
Accession # Q9BYF1
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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ACE‑2 in Human Kidney. ACE-2 was detected in immersion fixed paraffin-embedded sections of human kidney using Human ACE-2 Biotinylated Antigen Affinity-purified Polyclonal Antibody (Catalog # BAF933) at 15 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS008) and counterstained with hematoxylin (blue). View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: ACE-2
ACE-2, also called ACEH (ACE homolog), is an integral membrane protein and a zinc metalloprotease of the ACE family that also includes somatic and germinal ACE (1). Human ACE-2 has about 40% amino acid identity to the N- and C-terminal domains of human somatic ACE. The predicted human ACE-2 protein sequence consists of 805 amino acids, including a N-terminal signal peptide, a single catalytic domain, a C-terminal membrane anchor, and a short cytoplasmic tail. ACE-2 cleaves angiotensins I and II as a carboxypeptidase. ACE-2 mRNA is found at high levels in testis, kidney, and heart and at moderate levels in colon, small intestine, and ovary. Classical ACE inhibitors such as captopril and lisinopril do not inhibit ACE-2 activity. Novel peptide inhibitors of ACE-2 do not inhibit ACE activity (2). Genetic data from Drosophila, mice and rats show that ACE-2 is an essential regulator of heart function in vivo (3).
- Tipnis, S.R. et al. (2000) J. Biol. Chem. 275:33238.
- Crackower, M.A. et al. (2002) Nature 417:822.
- Huang, L. et al. (2003) J. Biol. Chem. 278:15532.
Product Datasheets
Citations for Human ACE-2 Biotinylated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 10
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Immune Dysregulation in Acute SARS-CoV-2 Infection
Authors: Lauren Grimm, Chinyere Onyeukwu, Grace Kenny, Danielle M. Parent, Jia Fu, Shaurya Dhingra et al.
Pathogens and Immunity
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Development of an aerosol intervention for COVID-19 disease: Tolerability of soluble ACE2 (APN01) administered via nebulizer
Authors: RH Shoemaker, RA Panettieri, SK Libutti, HS Hochster, NR Watts, PT Wingfield, P Starkl, L Pimenov, R Gawish, A Hladik, S Knapp, D Boring, JM White, Q Lawrence, J Boone, JD Marshall, RL Matthews, BD Cholewa, JW Richig, BT Chen, DL McCormick, R Gugensberg, S Höller, JM Penninger, G Wirnsberge
PLoS ONE, 2022-07-11;17(7):e0271066.
Species: Human
Sample Types: Protein
Applications: ELISA Capture -
Baricitinib attenuates the proinflammatory phase of COVID-19 driven by lung-infiltrating monocytes
Authors: Brian Dobosh, Keivan Zandi, Diego Moncada Giraldo, Shu Ling Goh, Kathryn Musall, Milagros Aldeco et al.
Cell Reports
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SARS-CoV-2 electrochemical immunosensor based on the spike-ACE2 complex
Authors: V Vásquez, MC Navas, JA Jaimes, J Orozco
Analytica chimica acta, 2022-03-23;1205(0):339718.
Species: Human
Sample Types: Whole Cells
Applications: ELISA Development -
Common cardiac medications potently inhibit ACE2 binding to the SARS-CoV-2 Spike, and block virus penetration and infectivity in human lung cells
Authors: H Caohuy, O Eidelman, T Chen, S Liu, Q Yang, A Bera, NI Walton, TT Wang, HB Pollard
Scientific Reports, 2021-11-12;11(1):22195.
Species: Human
Sample Types: Recombinant Proteins
Applications: ELISA Detection -
Development of a novel, pan-variant aerosol intervention for COVID-19
Authors: RH Shoemaker, RA Panettieri, SK Libutti, HS Hochster, NR Watts, PT Wingfield, P Starkl, L Pimenov, R Gawish, A Hladik, S Knapp, D Boring, JM White, Q Lawrence, J Boone, JD Marshall, RL Matthews, BD Cholewa, JW Richig, BT Chen, DL McCormick, R Gugensberg, S Höller, JM Penninger, G Wirnsberge
bioRxiv : the preprint server for biology, 2021-09-20;0(0):.
Species: Human
Sample Types: Virus
Applications: ELISA Detection -
Convalescent plasma-mediated resolution of COVID-19 in a patient with humoral immunodeficiency
Authors: Kazuhito Honjo, Ronnie M. Russell, Ran Li, Weimin Liu, Regina Stoltz, Edlue M. Tabengwa et al.
Cell Reports Medicine
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Alternative pathways for angiotensin II production as an important determinant of kidney damage in endotoxemia
Authors: Rodolfo Mattar Rosa, Juliana Almada Colucci, Rodrigo Yokota, Roseli Peres Moreira, Danielle Sanches Aragão, Amanda Aparecida Ribeiro et al.
American Journal of Physiology-Renal Physiology
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The Identification of a Calmodulin-Binding Domain within the Cytoplasmic Tail of Angiotensin-Converting Enzyme-2
Authors: Zon W. Lai, Rebecca A. Lew, Michael A. Yarski, Fi-Tjen Mu, Robert K. Andrews, A. Ian Smith
Endocrinology
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Furin cleavage of the SARS coronavirus spike glycoprotein enhances cell-cell fusion but does not affect virion entry.
Authors: Follis KE, York J, Nunberg JH
Virology, 2006-03-07;350(2):358-69.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry
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