D-AP5
Chemical Name: D-(-)-2-Amino-5-phosphonopentanoic acid
Purity: ≥99%
Biological Activity
D-AP5 is a selective NMDA receptor antagonist that competes with glutamate binding and is commonly used to inhibit NMDA-dependent synaptic plasticity. D-AP5 is the more active isomer of DL-AP5 (Cat. No. 0105) and displays approximately 52-fold higher potency than the L-isomer, L-AP5 (Cat. No. 0107). In vitro D-AP5 reduces NMDA-induced depolarization of cortical neurons, with no effect on the response to L-Quisqualic acid (Cat. No. 0188) or Kainic acid (Cat. No. 0222). Following spinal injection, D-AP5 results in rapid reduction of NMDA-response but no effect on spontaneously active neurons.DL Mixture, L-isomer and sodium salt also available.
Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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Citations for D-AP5
The citations listed below are publications that use Tocris products. Selected citations for D-AP5 include:
372 Citations: Showing 1 - 10
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Voltage-gated potassium channels ensure action potential shape fidelity in distal axons.
Authors: Sabater Et al.
J Neurosci 2021;41:5372
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Axonal mechanisms mediating γ-aminobutyric acid receptor type A (GABA-A) inhibition of striatal dopamine release.
Authors: Kramer Et al.
ELife 2020;9
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Nucleus Accumbens Tac1-Expressing Neurons Mediate Stress-Induced Anhedonia-like Behavior in Mice.
Authors: He Et al.
Cell Rep 2020;33
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Functional Dissection of Basal Ganglia Inhibitory Inputs onto Substantia Nigra Dopaminergic Neurons.
Authors: Evans Et al.
Cell Rep 2020;32
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Polysynaptic inhibition between striatal cholinergic interneurons shapes their network activity patterns in a dopamine-dependent manner.
Authors: Dorst Et al.
Nat Comms 2020;11:5113
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The adhesion-GPCR BAI1 shapes dendritic arbors via Bcr-mediated RhoA activation causing late growth arrest.
Authors: Duman Et al.
Elife 2019;8
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NMDAR-Activated PP1 Dephosphorylates GluN2B to Modulate NMDAR Synaptic Content.
Authors: Chiu Et al.
Cell Rep 2019;28:332
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Pharmacological Dissection of Intrinsic Optical Signal Reveals a Functional Coupling between Synaptic Activity and Astrocytic Volume Transient.
Authors: Woo Et al.
Exp Neurobiol 2019;28:30
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Activation of Astrocytic μ-Opioid Receptor Causes Conditioned Place Preference.
Authors: Nam Et al.
Cell Rep 2019;28:1154
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Myosin VI Drives Clathrin-Mediated AMPA Receptor Endocytosis to Facilitate Cerebellar Long-Term Depression.
Authors: Wagner Et al.
Cell Rep 2019;28:11
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Routing Hippocampal Information Flow through Parvalbumin Interneuron Plasticity in Area CA2.
Authors: Nasrallah Et al.
Cell Rep 2019;27:86
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Transient, Consequential Increases in Extracellular Potassium Ions Accompany Channelrhodopsin2 Excitation.
Authors: Octeau Et al.
Cell Rep 2019;27:2249
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A Single-Cell Model for Synaptic Transmission and Plasticity in Human iPSC-Derived Neurons.
Authors: Meijer Et al.
Cell Rep 2019;27:2199
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Kibra Modulates Learning and Memory via Binding to Dendrin.
Authors: Ji Et al.
Cell Rep 2019;26:2064
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High-Frequency Microdomain Ca2+ Transients and Waves during Early Myelin Internode Remodeling.
Authors: Battefeld Et al.
Cell Rep 2019;26:182
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Homeostatic Intrinsic Plasticity Is Functionally Altered in Fmr1 KO Cortical Neurons.
Authors: Bülow Et al.
Cell Rep 2019;26:1378
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KCC2-Mediated Cl- Extrusion Modulates Spontaneous Hippocampal Network Events in Perinatal Rats and Mice.
Authors: Spoljaric Et al.
Cell Rep 2019;26:1073
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Role of intraganglionic transmission in the trigeminovascular pathway.
Authors: Zhang Et al.
Mol Pain 2019;15:1744806919836570
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Simultaneous voltage and calcium imaging and optogenetic stimulation with high sensitivity and a wide field of view.
Authors: Nguyen Et al.
Biomed Opt Express 2019;10:789
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Novel positive allosteric modulators of glutamate transport have neuroprotective properties in an in vitro excitotoxic model.
Authors: Falcucci Et al.
ACS Chem Neurosci 2019;10:3437
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How Gastrin-Releasing Peptide Opens the Spinal Gate for Itch.
Authors: Pagani Et al.
Neuron 2019;
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Activity-Dependent Downscaling of Subthreshold Synaptic Inputs during Slow-Wave-Sleep-like Activity In Vivo.
Authors: González-Rueda Et al.
Neuron 2018;97:1244
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DA neuron glutamate cotransmission evokes a delayed excitation in lateral dorsal striatal cholinergic interneurons.
Authors: Chuhma Et al.
Elife 2018;7
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A circuit from hippocampal CA2 to lateral septum disinhibits social aggression.
Authors: Leroy Et al.
Nature 2018;564:213
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The Microglial Innate Immune Receptor TREM2 Is Required for Synapse Elimination and Normal Brain Connectivity.
Authors: Filipello Et al.
Immunity 2018;48:979
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DA Cells Differentially Regulate Striatal Cholinergic Transmission across Regions through Corelease of DA and Glutamate.
Authors: Cai and Ford
Cell Rep 2018;25:3148
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Calcium Channel CaV2.3 Subunits Regulate Hepatic Glucose Production by Modulating Leptin-Induced Excitation of Arcuate Pro-opiomelanocortin Neurons.
Authors: Smith Et al.
Cell Rep 2018;25:278
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Activity-Dependent Netrin-1 Secretion Drives Synaptic Insertion of GluA1-Containing AMPA Receptors in the Hippocampus.
Authors: Glasgow Et al.
Cell Rep 2018;25:168
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CAST/ELKS Proteins Control Voltage-Gated Ca2+ Channel Density and Synaptic Release Probability at a Mammalian Central Synapse.
Authors: Dong Et al.
Cell Rep 2018;24:284
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The locus coeruleus drives disinhibition in the midline thalamus via a dopaminergic mechanism.
Authors: Beas Et al.
Nat Neurosci 2018;21:963
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Astrocytic Activation Generates De Novo Neuronal Potentiation and Memory Enhancement.
Authors: Adamsky Et al.
Cell 2018;174:59
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All-optical synaptic electrophysiology probes mechanism of ketamine-induced disinhibition.
Authors: Fan Et al.
Nat Methods 2018;15:823
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(2R,6R)-hydroxynorKA rescues chronic stress-induced depression-like behavior through its actions in the midbrain periaqueductal gray.
Authors: Chou Et al.
Neuropharmacology 2018;139:1
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Drebrin Isoforms Critically Regulate NMDAR- and mGluR-Dependent LTD Induction.
Authors: Yasuda Et al.
Front Cell Neurosci 2018;12:330
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Proximodistal Heterogeneity of Hippocampal CA3 Pyramidal Neuron Intrinsic Properties, Connectivity, and Reactivation during Memory Recall.
Authors: Sun Et al.
Neuron 2017;95:656
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Initiation of Behavioral Response to Antidepressants by Cholecystokinin Neurons of the Dentate Gyrus.
Authors: Medrihan Et al.
Neuron 2017;95:564
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Encoding of Discriminative Fear Memory by Input-Specific LTP in the Amygdala.
Authors: Kim and Cho
Neuron 2017;95:1129
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Input-Timing-Dependent Plasticity in the Hippocampal CA2 Region and Its Potential Role in Social Memory.
Authors: Leroy Et al.
Neuron 2017;95:1089
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IGF1-Dependent Synaptic Plasticity of Mitral Cells in Olfactory Memory during Social Learning.
Authors: Liu Et al.
Neuron 2017;95:106
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A Critical Role of Presynaptic Cadherin/Catenin/p140Cap Complexes in Stabilizing Spines and Functional Synapses in the Neocortex.
Authors: Li Et al.
Neuron 2017;94:1155
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Impairments of spatial memory in an Alzheimer's disease model via degeneration of hippocampal cholinergic synapses.
Authors: Zhu Et al.
Nat Commun 2017;8:1676
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Differential processing of thalamic information via distinct striatal interneuron circuits.
Authors: Assous
Nat Commun 2017;8:15860
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Subtype-specific effects of DArgic D2 receptor activation on synaptic trains in layer V pyramidal neurons in the mouse prefrontal cortex.
Authors: Leyrer-Jackson
Physiol Rep 2017;5(22):e13499
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Synaptically driven phosphorylation of ribosomal protein S6 is differentially regulated at active synapses versus dendrites and cell bodies by MAPK and PI3K/mTOR signaling pathways.
Authors: Pirbhoy Et al.
Learn Mem 2017;24:341
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DA D4 receptor activation restores CA1 LTP in hippocampal slices from aged mice.
Authors: Guo
Aging Cell 2017;16(6):1323
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Toll-like receptor 4 deficiency alters nucleus accumbens synaptic physiology and drug reward behavior.
Authors: Kashima and Grueter
Proc Natl Acad Sci U S A. 2017;114(3):8865
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Nitric Oxide Is Required for L-Type Ca(2+) Channel-Dependent Long-Term Potentiation in the Hippocampus.
Authors: Pigott and Garthwaite
Front Synaptic Neurosci 2016;8:17
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Glycinergic dysfunction in a subpopulation of dorsal horn interneurons in a rat model of neuropathic pain
Authors: Imlach Et al.
Scientific Reports 2016;6:37104
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Increased GABAB receptor signaling in a rat model for schizophrenia
Authors: Selten Et al.
Scientific Reports 2016;6:34240
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Signaling mechanism for modulation by ATP of glycine receptors on rat retinal ganglion cells.
Authors: Zhang Et al.
Sci Rep 2016;6:28938
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Endocannabinoid dynamics gate spike-timing dependent depression and potentiation.
Authors: Cui Et al.
Elife 2016;5:e13185
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A cholinergic basal forebrain feeding circuit modulates appetite suppression
Authors: Herman Et al.
Nature 2016;538:253
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Calcium-Permeable AMPA Receptors Mediate the Induction of the Protein Kinase A-Dependent Component of Long-Term Potentiation in the Hippocampus.
Authors: Park Et al.
J Neurosci 2016;36:622
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Context-Dependent Modulation of GABAAR-Mediated Tonic Currents.
Authors: Patel Et al.
J Neurosci 2016;36:607
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Hypocretin/Orexin Peptides Alter Spike Encoding by Serotonergic Dorsal Raphe Neurons through Two Distinct Mechanisms That Increase the Late Afterhyperpolarization.
Authors: Ishibashi Et al.
J Neurosci 2016;36:10097
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Activation of Muscarinic M1 Acetylcholine Receptors Induces Long-Term Potentiation in the Hippocampus.
Authors: Dennis Et al.
Cereb Cortex 2016;26:414
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Synaptic activation of ribosomal protein S6 phosphorylation occurs locally in activated dendritic domains.
Authors: Pirbhoy Et al.
Learn Mem 2016;23:255
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Diminished KCC2 confounds synapse specificity of LTP during senescence.
Authors: Ferando Et al.
Nat Neurosci 2016;19:1197
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Neuronal firing patterns outweigh circuitry oscillations in parkinsonian motor control.
Authors: Pan Et al.
J Clin Invest 2016;126:4516
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Differential modulation of repetitive firing and synchronous network activity in neocortical interneurons by inhibition of A-type K(+) channels and Ih.
Authors: Williams and Hablitz
Front Cell Neurosci 2015;9:89
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Novel agonists for serotonin 5-HT7 receptors reverse metabotropic glutamate receptor-mediated long-term depression in the hippocampus of wild-type and Fmr1 KO mice, a model of Fragile X Syndrome.
Authors: Costa Et al.
Front Behav Neurosci 2015;9:65
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NE Modulates Pyramidal Cell Synaptic Properties in the Anterior Piriform Cortex of Mice: Age-Dependent Effects of β-adrenoceptors.
Authors: Ghosh Et al.
Front Cell Neurosci 2015;9:450
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A pre-docking source for the power-law behavior of spontaneous quantal release: application to the analysis of LTP.
Authors: Lamanna Et al.
Front Cell Neurosci 2015;9:44
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Dendritic morphology, synaptic transmission, and activity of mature granule cells born following PilC-induced status epilepticus in the rat.
Authors: Gao Et al.
Front Cell Neurosci 2015;9:384
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GABAA receptor activity shapes the formation of inhibitory synapses between developing medium spiny neurons.
Authors: Arama Et al.
Front Cell Neurosci 2015;9:290
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Interaction of electrically evoked activity with intrinsic dynamics of cultured cortical networks with and without functional fast GABAergic synaptic transmission.
Authors: Baltz and Voigt
Front Cell Neurosci 2015;9:272
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Channel-mediated astrocytic glutamate modulates hippocampal synaptic plasticity by activating postsynaptic NMDA receptors.
Authors: Park Et al.
Mol Brain 2015;8:7
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Functional changes in glutamate transporters and astrocyte biophysical properties in a rodent model of focal cortical dysplasia.
Authors: Campbell Et al.
Front Cell Neurosci 2015;8:425
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Involvement of cAMP-guanine nucleotide exchange factor II in hippocampal long-term depression and behavioral flexibility.
Authors: Lee Et al.
Mol Brain 2015;8:38
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Activation of calcineurin underlies altered trafficking of α2 subunit containing GABAA receptors during prolonged epileptiform activity.
Authors: Eckel Et al.
Neuropharmacology 2015;88:82
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LRP8-Reelin-Regulated Neuronal Enhancer Signature Underlying Learning and Memory Formation.
Authors: Telese Et al.
Neuron 2015;86:696
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Calcium flux-independent NMDA receptor activity is required for Aβ oligomer-induced synaptic loss.
Authors: Birnbaum Et al.
Cell Death Dis 2015;6:e1791
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Brain ischemia downregulates the neuroprotective GDNF-Ret signaling by a calpain-dependent mechanism in cultured hippocampal neurons.
Authors: Curcio Et al.
Cell Death Dis 2015;6:e1645
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Wnt signalling tunes neurotransmitter release by directly targeting Synaptotagmin-1.
Authors: Ciani Et al.
Nat Commun 2015;6:8302
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Subventricular zone neural progenitors reverse TNF-α effects in cortical neurons.
Authors: Morini Et al.
Stem Cell Res Ther 2015;6:166
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Interactions of Human Autoantibodies with Hippocampal GABAergic Synaptic Transmission - Analyzing Antibody-Induced Effects ex vivo.
Authors: Haselmann Et al.
Front Neurol 2015;6:136
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MicroRNA miR124 is required for the expression of homeostatic synaptic plasticity.
Authors: Hou Et al.
Nat Commun 2015;6:10045
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Nitric oxide targets oligodendrocytes and promotes their morphological differentiation.
Authors: Garthwaite Et al.
Glia 2015;63:383
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GABAergic disinhibition and impaired KCC2 cotransporter activity underlie tumor-associated epilepsy.
Authors: Campbell Et al.
Glia 2015;63:23
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Histone deacetylase 3 inhibition re-establishes synaptic tagging and capture in aging through the activation of nuclear factor κ B.
Authors: Sharma Et al.
Sci Rep 2015;5:16616
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Modulation of AMPA receptor mediated current by nicotinic acetylcholine receptor in layer I neurons of rat prefrontal cortex.
Authors: Tang Et al.
Sci Rep 2015;5:14099
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Basolateral amygdala rapid glutamate release encodes an outcome-specific representation vital for reward-predictive cues to selectively invigorate reward-seeking actions.
Authors: Malvaez Et al.
Sci Rep 2015;5:12511
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Differential inhibition onto developing and mature granule cells generates high-frequency filters with variable gain.
Authors: Pardi Et al.
Elife 2015;4:e08764
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Retroactive modulation of spike timing-dependent plasticity by DA.
Authors: Brzosko Et al.
Elife 2015;4
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AMPA receptor mediated synaptic excitation drives state-dependent bursting in Purkinje neurons of zebrafish larvae.
Authors: Sengupta and Thirumalai
Elife 2015;4
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Neuron-glia signaling in developing retina mediated by neurotransmitter spillover.
Authors: Rosa Et al.
Elife 2015;4
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Pronociceptive and Antinociceptive Effects of Bupren. in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude.
Authors: Gerhold Et al.
J Neurosci 2015;35:9580
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An Asymmetric Increase in Inhibitory Synapse Number Underlies the Development of a Direction Selective Circuit in the Retina.
Authors: Morrie and Feller
J Neurosci 2015;35:9281
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Disruption of Fgf13 causes synaptic excitatory-inhibitory imbalance and genetic epilepsy and febrile seizures plus.
Authors: Puranam Et al.
J Neurosci 2015;35:8866
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Developmental changes in synaptic distribution in arcuate nucleus neurons.
Authors: Baquero Et al.
J Neurosci 2015;35:8558
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Different patterns of electrical activity lead to long-term potentiation by activating different intracellular pathways.
Authors: Zhu Et al.
J Neurosci 2015;35:621
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Abnormal excitability and episodic low-frequency oscillations in the cerebral cortex of the tottering mouse.
Authors: Cramer Et al.
J Neurosci 2015;35:5664
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BDNF interacts with endocannabinoids to regulate cocaine-induced synaptic plasticity in mouse midbrain DA neurons.
Authors: Zhong Et al.
J Neurosci 2015;35:4469
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Absence of plateau potentials in dLGN cells leads to a breakdown in retinogeniculate refinement.
Authors: Dilger Et al.
J Neurosci 2015;35:3652
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Miro1 Regulates Activity-Driven Positioning of Mitochondria within Astrocytic Processes Apposed to Synapses to Regulate Intracellular Calcium Signaling.
Authors: Stephen Et al.
J Neurosci 2015;35:15996
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Loss of Local Astrocyte Support Disrupts Action Potential Propagation and Glutamate Release Synchrony from Unmyelinated Hippocampal Axon Terminals In Vitro.
Authors: Sobieski Et al.
J Neurosci 2015;35:11105
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Afterhyperpolarization (AHP) regulates the frequency and timing of action potentials in the mitral cells of the olfactory bulb: role of olfactory experience.
Authors: Duménieu Et al.
Physiol Rep 2015;3
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Synapse-specific compartmentalization of signaling cascades for LTP induction in CA3 interneurons.
Authors: Galván Et al.
Neuroscience 2015;290:332
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Asynchronous GABA Release Is a Key Determinant of Tonic Inhibition and Controls Neuronal Excitability: A Study in the Synapsin II-/- Mouse.
Authors: Medrihan Et al.
Cereb Cortex 2015;25:3356
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Morphological and physiological evidence of a synaptic connection between the lateral parabrachial nucleus and neurons in the A7 catecholamine cell group in rats.
Authors: Liu Et al.
J Biomed Sci 2015;22:79
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Tau reduction prevents Aβ-induced axonal transport deficits by blocking activation of GSK3β.
Authors: Vossel Et al.
J Cell Biol 2015;209:419
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Neuraminidase inhibition primes short-term depression and suppresses long-term potentiation of synaptic transmission in the rat hippocampus.
Authors: Savotchenko Et al.
Neural Plast 2015;2015:908190
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Selective Effects of PDE10A Inhibitors on Striatopallidal Neurons Require Phosphatase Inhibition by DARPP-32(1,2,3).
Authors: Polito Et al.
Eneuro 2015;2
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Visual recognition memory, manifested as long-term habituation, requires synaptic plasticity in V1.
Authors: Cooke Et al.
Nat Neurosci 2015;18:262
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Functional α7 nicotinic receptors are expressed on immature granule cells of the postnatal dentate gyrus.
Authors: John Et al.
Brain Res 2015;1601:15
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The Posterodorsal Medial Amygdala Regulates the Timing of Puberty Onset in Female Rats.
Authors: Li Et al.
Endocrinology 2015;156:3725
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The rat retina has five types of ganglion-cell photoreceptors.
Authors: Reifler Et al.
Exp Eye Res 2015;130:17
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Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture.
Authors: Pasca Et al.
Nat Methods 2015;12:671
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PacT. induces acute pain via directly activating toll like receptor 4.
Authors: Yan Et al.
Mol Pain 2015;11:10
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Intrinsic excitability varies by sex in prepubertal striatal medium spiny neurons.
Authors: Dorris Et al.
J Neurophysiol 2015;113:720
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Structural elements that underlie Doc2β function during asynchronous synaptic transmission.
Authors: Xue Et al.
Proc Natl Acad Sci U S A 2015;112:E4316
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Tectal microcircuit generating visual selection commands on gaze-controlling neurons.
Authors: Kardamakis Et al.
Proc Natl Acad Sci U S A 2015;112:E1956
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ATRX tolerates activity-dependent histone H3 methyl/phos switching to maintain repetitive element silencing in neurons.
Authors: Noh Et al.
Proc Natl Acad Sci U S A 2015;112:6820
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Regulation of AMPA receptor phosphorylation by the neuropeptide PACAP38.
Authors: Toda and Huganir
Proc Natl Acad Sci U S A 2015;112:6712
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Giant ankyrin-G stabilizes somatodendritic GABAergic synapses through opposing endocytosis of GABAA receptors.
Authors: Tseng Et al.
Proc Natl Acad Sci U S A 2015;112:1214
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Apamin Boosting of Synaptic Potentials in CaV2.3 R-Type Ca2+ Channel Null Mice.
Authors: Wang Et al.
PLoS One 2015;10:e0139332
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Chloride Accumulators NKCC1 and AE2 in Mouse GnRH Neurons: Implications for GABAA Mediated Excitation.
Authors: Taylor-Burds Et al.
PLoS One 2015;10:e0131076
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G-Protein Coupled Receptor Kinase 2 Minimally Regulates Melanopsin Activity in Intrinsically Photosensitive Retinal Ganglion Cells.
Authors: Sexton and Gelder
PLoS One 2015;10:e0128690
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The effect of Dflu. on neuronal communication at a central synapse.
Authors: Mapelli Et al.
PLoS One 2015;10:e0123534
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Kinetic evaluation of photosensitivity in bi-stable variants of chimeric channelrhodopsins.
Authors: Hososhima Et al.
PLoS One 2015;10:e0119558
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α-Actinin-2 mediates spine morphology and assembly of the post-synaptic density in hippocampal neurons.
Authors: Hodges Et al.
PLoS One 2014;9:e101770
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Inhibitory projections from the ventral nucleus of the trapezoid body to the medial nucleus of the trapezoid body in the mouse.
Authors: Albrecht Et al.
Front Neural Circuits 2014;8:83
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Electrophysiological characterization of male goldfish (Carassius auratus) ventral preoptic area neurons receiving olfactory inputs.
Authors: Lado Et al.
Front Neurosci 2014;8:185
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DA neurons control striatal cholinergic neurons via regionally heterogeneous DA and glutamate signaling.
Authors: Chuhma Et al.
Neuron 2014;81:901
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HSF1 transcriptional activity mediates alcohol induction of Vamp2 expression and GABA release.
Authors: Varodayan and Harrison
Front Integr Neurosci 2014;7:89
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Distinct molecular components for thalamic- and cortical-dependent plasticity in the lateral amygdala.
Authors: Mirante Et al.
Front Mol Neurosci 2014;7:62
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Synaptic plasticity in glutamatergic and GABAergic neurotransmission following chronic Mem. treatment in an in vitro model of limbic epileptogenesis.
Authors: He and Bausch
Neuropharmacology 2014;77:379
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Quantitative profiling of peptides from RNAs classified as noncoding.
Authors: Prabakaran Et al.
Nat Commun 2014;5:5429
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Mitochondrial reactive oxygen species regulate the strength of inhibitory GABA-mediated synaptic transmission.
Authors: Accardi Et al.
Nat Commun 2014;5:3168
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Long-term depression-inducing stimuli promote cleavage of the synaptic adhesion molecule NGL-3 through NMDA receptors, matrix metalloproteinases and presenilin/γ-secretase.
Authors: Lee Et al.
Philos Trans R Soc Lond B Biol Sci 2014;369:20130158
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Mutant β-III spectrin causes mGluR1α mislocalization and functional deficits in a mouse model of spinocerebellar ataxia type 5.
Authors: Armbrust Et al.
J Neurosci 2014;34:9891
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Glycolysis and oxidative phosphorylation in neurons and astrocytes during network activity in hippocampal slices.
Authors: Ivanov Et al.
J Cereb Blood Flow Metab 2014;34:397
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Differential Tiam1/Rac1 activation in hippocampal and cortical neurons mediates differential spine shrinkage in response to oxygen/glucose deprivation.
Authors: Blanco-Suárez Et al.
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Activity-induced synaptic capture and exocytosis of the neuronal serine protease neurotrypsin.
Authors: Frischknecht Et al.
J Neurosci 2008;28:1568
-
Specific targeting of pro-death NMDA receptor signals with differing reliance on the NR2B PDZ ligand.
Authors: Soriano Et al.
J Neurosci 2008;28:10696
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Kinase networks integrate profiles of N-MthD.-aspartate receptor-mediated gene expression in hippocampus.
Authors: Coba Et al.
J Biol Chem 2008;283:34101
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Neuronal viability is controlled by a functional relation between synaptic and extrasynaptic NMDA receptors.
Authors: Léveillé Et al.
FASEB J 2008;22:4258
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IF.- γ directly induces neurotoxicity through a neuron specific, calcium-permeable complex of IFN- γ receptor and AMPA GluR1 receptor.
Authors: Mizuno Et al.
FASEB J 2008;22:1797
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The chemokine CCL2 activates p38 mitogen-activated protein kinase pathway in cultured rat hippocampal cells.
Authors: Cho and Gruol
J Neuroimmunol 2008;199:94
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An activity-regulated microRNA controls dendritic plasticity by down-regulating p250GAP.
Authors: Wayman Et al.
Proc Natl Acad Sci U S A 2008;105:9093
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Activity-dependent phosphorylation of Ser187 is required for SNAP-25-negative modulation of neuronal voltage-gated calcium channels.
Authors: Pozzi Et al.
Proc Natl Acad Sci U S A 2008;105:323
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Endocytosis and recycling of AMPA receptors lacking GluR2/3.
Authors: Biou Et al.
Proc Natl Acad Sci U S A 2008;105:1038
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Increased thalamocortical synaptic response and decreased layer IV innervation in GAP-43 knockout mice.
Authors: Albright Et al.
J Neurophysiol 2007;98:1610
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Muscarinic receptor activation elicits sustained, recurring depolarizations in reticulospinal neurons.
Authors: Smetana Et al.
J Neurophysiol 2007;97:3181
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TARP subtypes differentially and dose-dependently control synaptic AMPA receptor gating.
Authors: Milstein Et al.
Neuron 2007;55:905
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N-arachidonoyl-DA tunes synaptic transmission onto DArgic neurons by activating both cannabinoid and vanilloid receptors.
Authors: Marinelli Et al.
Neuropsychopharmacology 2007;32:298
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Axon and dendrite geography predict the specificity of synaptic connections in a functioning spinal cord network.
Authors: Li Et al.
Neural Dev 2007;2:17
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Compartment-specific modulation of GABAergic synaptic transmission by μ-opioid receptor in the mouse striatum with green fluorescent protein-expressing DA islands.
Authors: Miura Et al.
J Neurosci 2007;27:9721
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Loss of metabotropic glutamate receptor-dependent long-term depression via downregulation of mGluR5 after status epilepticus.
Authors: Kirschstein Et al.
J Neurosci 2007;27:7696
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New transmembrane AMPA receptor regulatory protein isoform, γ-7, differentially regulates AMPA receptors.
Authors: Kato Et al.
J Neurosci 2007;27:4969
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Synaptic scaffolding molecule alpha is a scaffold to mediate N-MthD.-aspartate receptor-dependent RhoA activation in dendrites.
Authors: Iida Et al.
Mol Cell Biol 2007;27:4388
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Lack of synapsin I reduces the readily releasable pool of synaptic vesicles at central inhibitory synapses.
Authors: Baldelli Et al.
J Neurosci 2007;27:13520
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Disynaptic amplification of metabotropic glutamate receptor 1 responses in the olfactory bulb.
Authors: Jan and Westbrook
J Neurosci 2007;27:132
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Somatodendritic release of glutamate regulates synaptic inhibition in cerebellar Purkinje cells via autocrine mGluR1 activation.
Authors: Duguid Et al.
J Neurosci 2007;27:12464
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Potent and specific action of the mGlu1 antagonists YM-298198 and JNJ16259685 on synaptic transmission in rat cerebellar slices.
Authors: Fukunaga Et al.
Br J Pharmacol 2007;151:870
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A form of perforant path LTP can occur without ERK1/2 phosphorylation or immediate early gene induction.
Authors: Steward Et al.
Learn Mem 2007;14:433
-
Synapse specificity of long-term potentiation breaks down with aging.
Authors: Ris and Godaux
Learn Mem 2007;14:185
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Amyloid precursor protein overexpression depresses excitatory transmission through both presynaptic and postsynaptic mechanisms.
Authors: Ting Et al.
Proc Natl Acad Sci U S A 2007;104:353
-
Fragile X mental retardation protein deficiency leads to excessive mGluR5-dependent internalization of AMPA receptors.
Authors: Nakamoto Et al.
Proc Natl Acad Sci U S A 2007;104:15537
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A role in learning for SRF: deletion in the adult forebrain disrupts LTD and the formation of an immediate memory of a novel context.
Authors: Etkin Et al.
Neuron 2006;50:127
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Chronic ethanol exposure and protracted abstinence alter NMDA receptors in central amygdala.
Authors: Roberto Et al.
Neuropsychopharmacology 2006;31:988
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Differential control of postsynaptic density scaffolds via actin-dependent and -independent mechanisms.
Authors: Kuriu Et al.
J Neurosci 2006;26:7693
-
Glutamatergic Control of Microvascular Tone by Distinct GABA Neurons in the Cerebellum.
Authors: Rancillac Et al.
J Neurosci 2006;26:6997
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Mice lacking brain/kidney phosphate-activated glutaminase have impaired glutamatergic synaptic transmission, altered breathing, disorganized goal-directed behavior and die shortly after birth.
Authors: Masson Et al.
J Neurosci 2006;26:4660
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Barrel map development relies on protein kinase A regulatory subunit II beta-mediated cAMP signaling.
Authors: Inan Et al.
J Neurosci 2006;26:4338
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Two coincidence detectors for spike timing-dependent plasticity in somatosensory cortex.
Authors: Bender Et al.
J Neurosci 2006;26:4166
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cAMP-dependent protein kinase postsynaptic localization regulated by NMDA receptor activation through translocation of an A-kinase anchoring protein scaffold protein.
Authors: Smith Et al.
J Neurosci 2006;26:2391
-
Differential reelin-induced enhancement of NMDA and AMPA receptor activity in the adult hippocampus.
Authors: Qiu Et al.
J Neurosci 2006;26:12943
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NR2B tyrosine phosphorylation modulates fear learning as well as amygdaloid synaptic plasticity.
Authors: Nakazawa Et al.
EMBO J 2006;25:2867
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Hydrogen sulfide is a novel prosecretory neuromodulator in the Guinea-pig and human colon.
Authors: Schicho Et al.
Gastroenterology 2006;131:1542
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Evidence for low GluR2 AMPA receptor subunit expression at synapses in the rat basolateral amygdala.
Authors: Gryder Et al.
J Neurochem 2005;94:1728
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Synaptic activity regulates interstitial fluid amyloid-beta levels in vivo.
Authors: Cirrito Et al.
Neuron 2005;48:913
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Adaptation to synaptic inactivity in hippocampal neurons.
Authors: Thiagarajan Et al.
Neuron 2005;47:725
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Neuromodulation via conditional release of endocannabinoids in the spinal locomotor network.
Authors: Kettunen Et al.
Neuron 2005;45:95
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The translation repressor 4E-BP2 is critical for eIF4F complex formation, synaptic plasticity, and memory in the hippocampus.
Authors: Banko Et al.
J Neurosci 2005;25:9581
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Strong effects of subphysiological temperature on the function and plasticity of mammalian presynaptic terminals.
Authors: Micheva and Smith
J Neurosci 2005;25:7481
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Lack of NMDA receptor subtype selectivity for hippocampal long-term potentiation.
Authors: Berberich Et al.
J Neurosci 2005;25:6907
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Reelin, very-low-density lipoprotein receptor, and apolipoprotein E receptor 2 control somatic NMDA receptor composition during hippocampal maturation in vitro.
Authors: Sinagra Et al.
J Neurosci 2005;25:6127
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Behavioral stress enhances hippocampal CA1 long-term depression through the blockade of the glutamate uptake.
Authors: Yang Et al.
J Neurosci 2005;25:4288
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PropF. suppresses synaptic responsiveness of somatosensory relay neurons to excitatory input by potentiating GABA(A) receptor chloride channels.
Authors: Ying and Goldstein
Mol Pain 2005;1:2
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Opioid-like actions of neuropeptide Y in rat substantia gelatinosa: Y1 suppression of inhibition and Y2 suppression of excitation.
Authors: Moran Et al.
J Neurophysiol 2004;92:3266
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Endocannabinoid-mediated metaplasticity in the hippocampus.
Authors: Chevaleyre and Castillo
Neuron 2004;43:871
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Glucose but not lactate in combination with acidosis aggravates ischemic neuronal death in vitro.
Authors: Cronberg Et al.
Stroke 2004;35:753
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Activity-dependent expression of inositol 1,4,5-trisphosphate receptor type 1 in hippocampal neurons.
Authors: Cai Et al.
J Biol Chem 2004;279:23691
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Tonotopic gradients of membrane and synaptic properties for neurons of the chicken nucleus magnocellularis.
Authors: Fukui and Ohmori
J Neurosci 2004;24:7514
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Extracellular signal-regulated protein kinase activation is required for metabotropic glutamate receptor-dependent long-term depression in hippocampal area CA1.
Authors: Gallagher Et al.
J Neurosci 2004;24:4859
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Physiological contribution of the astrocytic environment of neurons to intersynaptic crosstalk.
Authors: Piet Et al.
Proc Natl Acad Sci U S A 2004;101:2151
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Modulation of mitochondrial function by endogenous Zn2+ pools.
Authors: Sensi Et al.
Proc Natl Acad Sci U S A 2003;100:6157
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Separable features of visual cortical plasticity revealed by N-MthD.-aspartate receptor 2A signaling.
Authors: Fagiolini Et al.
Proc Natl Acad Sci U S A 2003;100:2854
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Bidirectional synaptic plasticity in the cerebellum-like mammalian dorsal cochlear nucleus.
Authors: Fujino and Oertel
Proc Natl Acad Sci U S A 2003;100:265
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Altered synaptic plasticity in a mouse model of fragile X mental retardation.
Authors: Huber Et al.
Proc Natl Acad Sci U S A 2002;99:7746
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Development of a human neuronal cell model for human immunodeficiency virus (HIV)-infected macrophage-induced neurotoxicity: apoptosis induced by HIV type 1 primary isolates and evidence for involvement of the Bcl-2/Bcl-xL-sensitive intrinsic apoptosis pa
Authors: Chen Et al.
J Virol 2002;76:9407
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The suppression of brain cold-stable microtubules in mice induces synaptic defects associated with neuroleptic-sensitive behavioral disorders.
Authors: Andrieux Et al.
Genes Dev 2002;16:2350
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Presynaptic N-MthD.-aspartate receptors at the parallel fiber-Purkinje cell synapse.
Authors: Casado Et al.
Proc Natl Acad Sci U S A 2000;97:11593
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A novel positive allosteric modulator of the GABA(A) receptor: the action of (+)-ROD188.
Authors: Thomet Et al.
Br J Pharmacol 2000;131:843
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Histamine depolarizes cholinergic interneurones in the rat striatum via a H(1)-receptor mediated action.
Authors: Bell Et al.
Br J Pharmacol 2000;131:1135
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Glutamate and gamma-aminobutyric acid mediate a heterosynaptic depression at mossy fiber synapses in the hippocampus.
Authors: Vogt and Nicoll
Proc Natl Acad Sci U S A 1999;96:1118
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Calcium dynamics in single spines during coincident pre- and postsynaptic activity depend on relative timing of back-propagating action potentials and subthreshold excitatory postsynaptic potentials.
Authors: Koester and Sakmann
Proc Natl Acad Sci U S A 1998;95:9596
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Glutamate receptor blockade at cortical synapses disrupts development of thalamocortical and columnar organization in somatosensory cortex.
Authors: Fox Et al.
Proc Natl Acad Sci U S A 1996;93:5584
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Mice deficient for prion protein exhibit normal neuronal excitability and synaptic transmission in the hippocampus.
Authors: Lledo Et al.
Proc Natl Acad Sci U S A 1996;93:2403
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Refinement of odor molecule tuning by dendrodendritic synaptic inhibition in the olfactory bulb.
Authors: Yokoi Et al.
Proc Natl Acad Sci U S A 1995;92:3371
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