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8-Hydroxy-DPAT hydrobromide

Catalog #: 0529
28 Citations Datasheet / COA / SDS

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0529 has been discontinued.
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8-Hydroxy-DPAT hydrobromide | CAS No. 76135-31-4 | 5-HT1 Receptor Agonists
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Description: Selective 5-HT1A agonist; also has moderate affinity for 5-HT7
Alternative Names: 8-OH-DPAT hydrobromide

Chemical Name: (±)-8-Hydroxy-2-dipropylaminotetralin hydrobromide

Purity: ≥98%

Product Details
Citations (28)
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

The standard selective 5-HT1A agonist. Also has moderate affinity for 5-HT7 receptors (pKi is 6.6 at the human 5-HT7 receptor expressed in HEK 293 cells). Reduces hippocampal 5-HT levels following systemic administration in rats in vivo.

R-enantiomer and 7-Hydroxy Isomer also available..

Technical Data

M.Wt:
328.29
Formula:
C16H25NO.HBr
Solubility:
Soluble to 10 mM in water with gentle warming and to 50 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at +4°C
CAS No:
76135-31-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

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Citations for 8-Hydroxy-DPAT hydrobromide

The citations listed below are publications that use Tocris products. Selected citations for 8-Hydroxy-DPAT hydrobromide include:

28 Citations: Showing 1 - 10

  1. Functional characterization of 5-HT1A and 5-HT1B serotonin receptor signaling through G-protein-activated inwardly rectifying K+ channels in a fluorescence-based membrane potential assay.
    Authors: Gadgaard & Jensen
    Biochem Pharmacol  2020;175
  2. Potentiation of the glycine response by serotonin on the substantia gelatinosa neurons of the trigeminal subnucleus caudalis in mice.
    Authors: Nguyen Et al.
    Korean J Physiol Pharmacol  2019;23:271
  3. Oncotoxic Properties of Serotonin Transporter Inhibitors and 5-HT1A Receptor Ligands.
    Authors: Walory Et al.
    Int J Mol Sci  2018;19
  4. Serotonin regulates prostate growth through androgen receptor modulation.
    Authors: Carvalho-Dias
    Sci Rep  2017;7(1):15428
  5. Selective Modulation of Axonal Sodium Channel Subtypes by 5-HT1A Receptor in Cortical Pyramidal Neuron.
    Authors: Yin Et al.
    Cereb Cortex  2017;27:509
  6. Modulatory Action by the Serotonergic System: Behavior and Neurophysiology in Drosophila melanogaster.
    Authors: Majeed Et al.
    Neural Plast  2016;2016:7291438
  7. Selective pharmacological blockade of the 5-HT7 receptor attenuates light and 8-OH-DPAT induced phase shifts of mouse circadian wheel running activity.
    Authors: Shelton Et al.
    Front Behav Neurosci  2015;8:453
  8. Sarpogrelate, a 5-HT2A Receptor Antagonist, Protects the Retina From Light-Induced Retinopathy.
    Authors: Tullis Et al.
    Eur J Neurosci  2015;56:4560
  9. 5-HT is a potent relaxant in rat superior mesenteric veins.
    Authors: Watts Et al.
    Invest Ophthalmol Vis Sci  2015;3:e00103
  10. N-MthD.-aspartate receptor channel blocker-like discriminative stimulus effects of nitrous oxide gas.
    Authors: Richardson and Shelton
    Cell Signal  2015;352:156
  11. Targeting melanocyte and melanoma stem cells by 8-hydroxy-2-dipropylaminotetralin.
    Authors: Bonchak Et al.
    Arch Biochem Biophys  2014;563:71
  12. Lasting neurobehavioral abnormalities in rats after neonatal activation of serotonin 1A and 1B receptors: possible mechanisms for serotonin dysfunction in autistic spectrum disorders.
    Authors: Khatri Et al.
    Psychopharmacology (Berl)  2014;231:1191
  13. GPER1 stimulation alters posttranslational modification of RGSz1 and induces desensitization of 5-HT1A receptor signaling in the rat hypothalamus.
    Authors: McAllister Et al.
    Neuroendocrinology  2014;100:228
  14. Hippocampal serotonin-1A receptor function in a mouse model of anxiety induced by long-term voluntary wheel running.
    Authors: Fuss Et al.
    Synapse  2013;67:648
  15. Conservation of 5-HT1A receptor-mediated autoinhibition of serotonin (5-HT) neurons in mice with altered 5-HT homeostasis.
    Authors: Araragi Et al.
    Front Pharmacol  2013;4:97
  16. The existence of FGFR1-5-HT1A receptor heterocomplexes in midbrain 5-HT neurons of the rat: relevance for neuroplasticity.
    Authors: Borroto-Escuela Et al.
    J Neurosci  2012;32:6295
  17. Neurite outgrowth mediated by the heat shock protein Hsp90α: a novel target for the antipsychotic drug aripipr.
    Authors: Ishima Et al.
    Transl Psychiatry  2012;2:e170
  18. Cannabidiol, a non-psychotropic component of cannabis, attenuates vomiting and nausea-like behaviour via indirect agonism of 5-HT(1A) somatodendritic autoreceptors in the dorsal raphe nucleus.
    Authors: Rock Et al.
    Br J Pharmacol  2012;165:2620
  19. Polysynaptic excitatory postsynaptic potentials that trigger spasms after spinal cord injury in rats are inhibited by 5-HT1B and 5-HT1F receptors.
    Authors: Murray Et al.
    J Neurophysiol  2011;106:925
  20. 5-HT(1A)-like receptor activation inhibits abstinence-induced metha. withdrawal in planarians.
    Authors: Rawls Et al.
    Neurosci Lett  2010;484:113
  21. Regulation of cortical and hippocampal 5-HT(1A) receptor function by corticosterone in GR+/- mice.
    Authors: Hensler Et al.
    Psychoneuroendocrinology  2010;35:469
  22. OE-induced desensitization of 5-HT1A receptor signaling in the paraventricular nucleus of the hypothalamus is independent of estrogen receptor-beta.
    Authors: Rossi Et al.
    Psychoneuroendocrinology  2010;35:1023
  23. The effects of aging and chronic fluox. treatment on circadian rhythms and suprachiasmatic nucleus expression of neuropeptide genes and 5-HT1B receptors.
    Authors: Duncan Et al.
    J Pharmacol Exp Ther  2010;31:1646
  24. Serotonin receptor 1A-modulated phosphorylation of glycine receptor α3 controls breathing in mice.
    Authors: Manzke Et al.
    J Clin Invest  2010;120:4118
  25. 5-hydroxytryptamine modulates migration, cytokine and chemokine release and T-cell priming capacity of dendritic cells in vitro and in vivo.
    Authors: Müller Et al.
    PLoS One  2009;4:e6453
  26. Serotonin targets inhibitory synapses to induce modulation of network functions.
    Authors: Manzke Et al.
    Philos Trans R Soc Lond B Biol Sci  2009;364:2589
  27. Gαo/i-stimulated proteosomal degradation of RGS20: a mechanism for temporal integration of Gs and Gi pathways.
    Authors: Pagano Et al.
    J Neurosci  2008;20:1190
  28. Evidence that the deficit in sexual behavior in adult rats neonatally exposed to cital. is a consequence of 5-HT1 receptor stimulation during development.
    Authors: Maciag Et al.
    Brain Res  2006;1125:171

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