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(R)-(+)-8-Hydroxy-DPAT hydrobromide

Catalog #: 1080
4 Citations Datasheet / COA / SDS

Discontinued Product

1080 has been discontinued.
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(R)-(+)-8-Hydroxy-DPAT hydrobromide | CAS No. 78095-19-9 | 5-HT1 Receptor Agonists
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Description: Selective 5-HT1A agonist; enantiomer of 8-Hydroxy-DPAT hydrobromide (Cat. No. 0529)

Chemical Name: (2R)-(+)-8-Hydroxy-2-(di-n-propylamino)tetralin hydrobromide

Purity: ≥98%

Product Details
Citations (4)
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

(R)-(+)-8-Hydroxy-DPAT hydrobromide is a full 5-HT1A serotonin receptor agonist. Reduces hippocampal 5-HT levels following systemic administration in rats in vivo. More active enantiomer of 8-Hydroxy-DPAT hydrobromide.

Racemate and 7-Hydroxy Isomer also available.

Technical Data

M.Wt:
328.29
Formula:
C16H25NO.HBr
Solubility:
Soluble to 75 mM in water and to 75 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at +4°C
CAS No:
78095-19-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

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Citations for (R)-(+)-8-Hydroxy-DPAT hydrobromide

The citations listed below are publications that use Tocris products. Selected citations for (R)-(+)-8-Hydroxy-DPAT hydrobromide include:

4 Citations: Showing 1 - 4

  1. 5-HT1A Receptor Function Makes Wound Healing a Happier Process.
    Authors: Sadiq Et al.
    Front Pharmacol  2019;9:1406
  2. SB-224289 Antagonizes the Antifungal Mechanism of the Marine Depsipeptide Papuamide A.
    Authors: Cassilly Et al.
    Psychopharmacology (Berl)  2016;11:e0154932
  3. The antipsychotic-like effects in rodents of the positive allosteric modulator Lu AF21934 involve 5-HT1A receptor signaling: mechanistic studies.
    Authors: Wierońska Et al.
    Oncoscience  2015;232:259
  4. Differential regulation of serotonin-1A receptor-stimulated [35S]GTP gamma S binding in the dorsal raphe nucleus by cital. and escital.
    Authors: Rossi Et al.
    Eur J Pharmacol  2008;583:103

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