Platelet Activated Integrin alpha 2b beta 3 Signaling
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Get Print Copyalpha 2b beta 3
alpha 2b beta 3
PKC beta
PKC beta
Release
Release
Activation
Activation
Activation
Activation
Production
Production
alpha 2b beta 3
alpha 2b beta 3
Formation
Formation
Signaling
Signaling
Overview of Platelet Signaling Through Activated Integrin α2bβ3
Integrin heterodimers are expressed on resting platelets in inactive conformations. They become activated by the recruitment of a RIAM-Rap1 containing protein complex in response to signaling from GP glycoproteins, GPCRs, and integrins themselves. Of the various integrin heterodimers expressed on platelets, Integrin α2bβ3 plays a primary role in platelet activation. Integrin α2bβ3 signaling leads to the activation of Src family kinases, PLC gamma, PKC, and PI-3 Kinase as well as the activation of proinflammatory signaling pathways. Integrin α2bβ3 signaling induces platelet granule release, integrin activation, and production of thromboxane A2.
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