Siglec-8: Products

Siglec-8, also known as SAF, is a transmembrane lectin that is expressed on eosinophils, basophils, and mast cells and shows a binding preference for the carbohydrate 6-O sulfated sLe(x). The functional paralog of human Siglec-8 is known as Siglec-F in mouse. Cross-linking of Siglec-8 inhibits Fc epsilon RI alpha-induced mast cell degranulation. It also induces eosinophil apoptosis, an effect that is enhanced by the eosinophil-activating cytokines IL-5, IL-33, and GM-CSF.

Products:

• Primary Antibodies
• Proteins & Enzymes
• cDNA Clones