PKC iota/lambda/zeta: Products

Atypical members of the Protein Kinase C (PKC) family of serine/threonine protein kinases include PKC iota/lambda and PKC zeta. Members of the atypical PKC subfamily are calcium-independent and do not require phosphatidylserine, diacylglycerol (DAG), or exogenous phorbol esters for activation. They have been shown to serve as convergent downstream targets for the PI 3-kinase and TC10 signaling pathways and can regulate NF-kappa B activation during inflammation and cell survival signaling. Atypical PKCs are also implicated in insulin signaling and glucose regulation.