Integrin alpha 10 beta 1: Products

Integrin alpha 10 beta 1 is one of twelve Integrin family adhesion receptors that share the beta 1 subunit. The non-covalent heterodimer of 160 kDa alpha 11 and 130 kDa beta 1/CD29 type I transmembrane glycoprotein subunits is expressed mainly on chondrocytes within cartilage, but also in fibrous connective tissues such as heart valves and ligaments. Divalent cations and intracellular (inside-out) signaling convert it to its most active, extended, and open conformation. a10b1 binds to Collagen types II and IX as well as Laminins. Its expression on melanoma cells correlates with cell migration.