FoxM1: Products

FoxM1 (Forkhead box protein M1; also FKHL16, HFH11 and WIN) is a 90 - 100 kDa member of the winged helix transcription factor gene family. It is expressed in proliferating and tumor cells and promotes the transition from G1 to S phase and G2 to M phase within the cell cycle. Human FoxM1 is 763 amino acids (aa) in length. It contains three PEST sequences (aa 22 - 34, 460 - 472 and 478 - 515), a forkhead DNA binding domain (aa 235 - 327), a Pro/Ser/Thr-rich region (aa 480 - 513) and a phosphorylation site at Ser704. There are at least two splice variants of FoxM1. The first shows a 38 aa insertion after Val423. This blocks FoxM1 transcriptional activation activity. The second variant shows a deletion of aa 326 - 340. Over aa 642 - 763, human FoxM1 shares 73% aa identity with mouse FoxM1.