Activin AC: Products

Activins and Inhibins are TGF-beta superfamily proteins that regulate a wide range of processes including mesoderm induction, reproductive system development and function, liver growth and regeneration, wound healing, and inflammation. Activins signal through heterodimeric receptor complexes composed of type I (Activin RIA or RIB) and type II (Activin RIIA or RIIB) transmembrane Ser/Thr kinases.

Activin AC is a heterodimer of beta A and beta C subunits, both of which are expressed in the liver, pituitary, ovary, testis, and adrenal gland. The beta C subunit may dimerize with beta A, beta B, or the Inhibin alpha subunit. The beta C subunit modulates Activin-induced effects by forming intracellular dimers with the beta A subunit and impeding the release of Activins A, AB, and B.