Human LAP TGF-beta 1 Biotinylated Antibody Summary
Leu30-Arg278 (Cys33Ser)
Accession # P01137
Applications
Human LAP TGF-beta 1 Sandwich Immunoassay
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: LAP (TGF-beta 1)
The TGF-beta family includes several related proteins (70 - 80% sequence homology) from mammalian, avain or Xenopus systems that are now designated TGF-beta 1, TGF-beta 2, TGF-beta 1.2, TGF-beta 3, TGF-beta 4 and TGF-beta 5. These proteins are secreted by cells in the form of an inactive complex, referred to as latent TGF-beta, that consists of TGF-beta associated non-covalently with LAP. These two proteins are synthesized as a single pro-peptide that is cleaved in a post Golgi compartment prior to secretion. Different TGF-beta family members are naturally associated with their own distinct LAPs.
Product Datasheets
Citations for Human LAP TGF-beta 1 Biotinylated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 5
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De novo design of highly selective miniprotein inhibitors of integrins ?v?6 and ?v?8
Authors: Roy, A;Shi, L;Chang, A;Dong, X;Fernandez, A;Kraft, JC;Li, J;Le, VQ;Winegar, RV;Cherf, GM;Slocum, D;Poulson, PD;Casper, GE;Vallecillo-Zúniga, ML;Valdoz, JC;Miranda, MC;Bai, H;Kipnis, Y;Olshefsky, A;Priya, T;Carter, L;Ravichandran, R;Chow, CM;Johnson, MR;Cheng, S;Smith, M;Overed-Sayer, C;Finch, DK;Lowe, D;Bera, AK;Matute-Bello, G;Birkland, TP;DiMaio, F;Raghu, G;Cochran, JR;Stewart, LJ;Campbell, MG;Van Ry, PM;Springer, T;Baker, D;
Nature communications
Species: Human
Sample Types: Recombinant Protein
Applications: Bioassay -
L(59) TGF-beta LAP degradation products serve as a promising blood biomarker for liver fibrogenesis in mice
Authors: Mitsuko Hara, Ikuyo Inoue, Yuta Yamazaki, Akiko Kirita, Tomokazu Matsuura, Scott L. Friedman et al.
Fibrogenesis & Tissue Repair
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Systemic and local characterization of regulatory T cells in a chronic fungal infection in humans.
Authors: Cavassani KA, Campanelli AP, Moreira AP, Vancim JO, Vitali LH, Mamede RC, Martinez R, Silva JS
J. Immunol., 2006-11-01;177(9):5811-8.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Cord blood CD4(+)CD25(+)-derived T regulatory cell lines express FoxP3 protein and manifest potent suppressor function.
Authors: Godfrey WR, Spoden DJ, Ge YG, Baker SR, Liu B, Levine BL, June CH, Blazar BR, Porter SB
Blood, 2004-09-16;105(2):750-8.
Species: Human
Sample Types: Cell Culture Supernates
Applications: Flow Cytometry -
TGF-beta 1 plays an important role in the mechanism of CD4+CD25+ regulatory T cell activity in both humans and mice.
Authors: Kitani A, Fuss I, Pedersen A, Nawata H
J. Immunol., 2004-01-15;172(2):834-42.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry
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I tested the antibody using direct ELISA to see if it cross reacted with mouse latent TGF beta or mature mouse TGF beta 1 recombinant proteins.
