Human FOLR1 Biotinylated Antibody Summary
Arg25-Met233
Accession # P15328
Applications
Human FOLR1 Sandwich Immunoassay
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: FOLR1
Folate Receptor 1 (FOLR1), also known as Folate Receptor alpha and Folate Binding Protein (FBP), is a 37‑42 kDa protein that mediates the cellular uptake of folic acid and reduced folates. Dietary folates are required for many key metabolic processes including nucleotide and methionine synthesis, the interconversion of glycine and serine, and histidine breakdown (1, 2). Mature FOLR1 is an N-glycosylated protein that is anchored to the cell surface by a GPI linkage (3‑6). Human FOLR1 shares 83% amino acid sequence identity with mouse and rat FOLR1. FOLR1 is predominantly expressed on epithelial cells and is dramatically upregulated on many carcinomas (7, 8). It is critically required during early embryogenesis as shown in knockout mice which die in utero with gross morphological defects (9). FOLR1 is internalized to the endosomal system where it dissociates from its ligand before recycling to the cell surface (6, 10). A soluble form of FOLR1 can be proteolytically shed from the cell surface into the serum and breast milk (11).
- Kelemen, L.E. (2006) Int. J. Cancer 119:243.
- Fowler, B. et al. (2001) Kidney Int. 59:S-221.
- Luhrs, C.A. et al. (1989) J. Biol. Chem. 264:21446.
- Lacey, S.W. et al. (1989) J. Clin. Invest. 84:715.
- Elwood, P.C. (1989) J. Biol. Chem. 264:14893.
- Rijnboutt, S. et al. (1996) J. Cell Biol. 132:35.
- Ross, J.F. et al. (1994) Cancer 73:2432.
- Parker, N. et al. (2005) Anal. Biochem. 338:284.
- Piedrahita, J.A. et al. (1999) Nat. Genet. 23:228.
- Paulos, C.M. et al. (2004) Mol. Pharmacol. 66:1406.
- Elwood, P.C. et al. (1991) J. Biol. Chem. 26:2346.
Product Datasheets
Citations for Human FOLR1 Biotinylated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 5
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Safety and anti-tumour activity of the IgE antibody MOv18 in patients with advanced solid tumours expressing folate receptor-alpha: a phase I trial
Authors: Spicer, J;Basu, B;Montes, A;Banerji, U;Kristeleit, R;Miller, R;Veal, GJ;Corrigan, CJ;Till, SJ;Figini, M;Canevari, S;Barton, C;Jones, P;Mellor, S;Carroll, S;Selkirk, C;Nintos, G;Kwatra, V;Funingana, IG;Doherty, G;Gould, HJ;Pellizzari, G;Nakamura, M;Ilieva, KM;Khiabany, A;Stavraka, C;Chauhan, J;Gillett, C;Pinder, S;Bax, HJ;Josephs, DH;Karagiannis, SN;
Nature communications
Species: Human
Sample Types: Serum
Applications: ELISA Detection -
Folate receptor alpha in ovarian cancer tissue and patient serum is associated with disease burden and treatment outcomes
Authors: HJ Bax, J Chauhan, C Stavraka, A Santaolall, G Osborn, A Khiabany, M Grandits, J López-Aben, LCGF Palhares, C Chan Wah H, A Robinson, A Pope, N Woodman, C Naceur-Lom, S Malas, JEM Coumbe, M Nakamura, R Laddach, S Mele, S Crescioli, AM Black, S Lombardi, S Canevari, M Figini, A Sayasneh, S Tsoka, K FitzGerald, C Gillett, S Pinder, M Van Hemelr, R Kristeleit, S Ghosh, A Montes, J Spicer, SN Karagianni, DH Josephs
British Journal of Cancer, 2022-11-19;0(0):.
Species: Human
Sample Types: Serum
Applications: ELISA Detection -
Targeting of folate receptor beta on acute myeloid leukemia blasts with chimeric antigen receptor-expressing T cells.
Authors: Lynn R, Poussin M, Kalota A, Feng Y, Low P, Dimitrov D, Powell D
Blood, 2015-04-17;125(22):3466-76.
Species: Human
Sample Types: Whole Cells
Applications: Neutralization -
Conditions associated with circulating tumor-associated folate receptor 1 protein in healthy men and women.
Authors: Kelemen L, Brenton J, Parkinson C, C Whitaker H, Piskorz A, Csizmadi I, Robson P
PLoS ONE, 2014-05-08;9(5):e96542.
Species: Human
Sample Types: Serum
Applications: ELISA Development (Detection) -
Harnessing engineered antibodies of the IgE class to combat malignancy: initial assessment of FcvarepsilonRI-mediated basophil activation by a tumour-specific IgE antibody to evaluate the risk of type I hypersensitivity.
Authors: Rudman SM, Josephs DH, Cambrook H, Karagiannis P, Gilbert AE, Dodev T, Hunt J, Koers A, Montes A, Taams L, Canevari S, Figini M, Blower PJ, Beavil AJ, Nicodemus CF, Corrigan C, Kaye SB, Nestle FO, Gould HJ, Spicer JF, Karagiannis SN
Clin. Exp. Allergy, 2011-05-16;41(10):1400-1413.
Species: Human
Sample Types: Serum
Applications: ELISA Development
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