Human BCMA/TNFRSF17 Biotinylated Antibody Summary
Met1-Ala54
Accession # Q6PE46
Applications
Human BCMA/TNFRSF17 Sandwich Immunoassay
Human/Primate BCMA/TNFRSF17 Sandwich Immunoassay
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Detection of BCMA/TNFRSF17 in U266 cells by Flow Cytometry U266 cells were stained with Goat Anti-Human BCMA/TNFRSF17 Biotinylated Antigen Affinity-purified Polyclonal Antibody (Catalog # BAF193, filled histogram) or isotype control antibody (Catalog # BAF108, open histogram) followed by Streptavidin-Phycoerythrin (Catalog # F0040). View our protocol for Staining Membrane-associated Proteins.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: BCMA/TNFRSF17
BCMA, B cell maturation, is a member of the TNF receptor superfamily. It has been designated TNFRSF17. BCMA is a type III membrane protein containing one extracellular cysteine rich domain. Within the TNFRSF, it shares the highest homology with TACI. BCMA and TACI have both been shown to bind to APRIL and BAFF, members of the TNF ligand superfamily. BCMA expression has been found in immune organs and mature B cell lines. Although some expression has been observed at the cell surface, BCMA appears to be localized to the Golgi compartment. The binding of BCMA to APRIL or BAFF has been shown to stimulate IgM production in peripheral blood B cells and increase the survival of cultured B cells. This data suggests that BCMA may play an important role in B cell development, function and regulation. Human BCMA is a 184 amino acid (aa) protein consisting of a 54 aa extracellular domain, a 23 aa transmembrane domain, and a 107 aa intracellular domain. Mouse and human BCMA share 62% amino acid identity.
- Madry, C. et al. (1998) Int. Immunol. 10:1693.
- Gras, M. et al. (1995) Int. Immunol. 7:1093.
- Kwon, B. et al. (1999) Curr. Opin. Immunol. 11:340.
- Marsters, S. et al. (2000) Curr. Biol. 10:785.
- Thompson, J. et al. (2000) J. Exp. Med. 192:129.
Product Datasheets
Citations for Human BCMA/TNFRSF17 Biotinylated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 5
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B-cell Maturation Antigen is a Promising Target for Adoptive T-cell Therapy of Multiple Myeloma.
Authors: Carpenter, Robert O, Evbuomwan, Moses O, Pittaluga, Stefania, Rose, Jeremy J, Raffeld, Mark, Yang, Shicheng, Gress, Ronald E, Hakim, Frances, Kochenderfer, James N
Clin Cancer Res, 2013-01-23;19(0):2048-60.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Fusion Toxin BLyS-Gelonin Inhibits Growth of Malignant Human B Cell Lines In Vitro and In Vivo.
Authors: Luster, Troy A, Mukherjee, Ipsita, Carrell, Jeffrey, Cho, Yun Hee, Gill, Jeffrey, Kelly, Lizbeth, Garcia, Andy, Ward, Christop, Oh, Luke, Ullrich, Stephen, Migone, Thi-Sau, Humphreys, Robin
PLoS ONE, 2012-10-09;7(10):e47361.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
IL-21 and BAFF/BLyS synergize in stimulating plasma cell differentiation from a unique population of human splenic memory B cells.
Authors: Ettinger R, Sims GP, Robbins R, Withers D, Fischer RT, Grammer AC, Kuchen S, Lipsky PE
J. Immunol., 2007-03-01;178(5):2872-82.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
B-lymphocyte stimulator (BLyS) stimulates immunoglobulin production and malignant B-cell growth in Waldenstrom macroglobulinemia.
Authors: Elsawa SF, Novak AJ, Grote DM, Ziesmer SC, Witzig TE, Kyle RA, Dillon SR, Harder B, Gross JA, Ansell SM
Blood, 2005-11-22;107(7):2882-8.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Decreased survival of B cells of HIV-viremic patients mediated by altered expression of receptors of the TNF superfamily.
Authors: Moir S, Malaspina A, Pickeral OK, Donoghue ET, Vasquez J, Miller NJ, Krishnan SR, Planta MA, Turney JF, Justement JS, Kottilil S, Dybul M, Mican JM, Kovacs C, Chun TW, Birse CE, Fauci AS
J. Exp. Med., 2004-10-04;200(7):587-99.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry
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